Sarsasapogenin attenuates Alzheimer-like encephalopathy in diabetes

Extracts from Chinese herbs with anti-amyloid and neuroprotective activities

(2021) Zuzana Bednarikova et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sarsasapogenin ameliorates diabetes‐associated memory impairment and neuroinflammation through down‐regulation of PAR ‐1 receptor

(2021) Li Kong et al.   PHYTOTHERAPY RESEARCH

A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway

(2019) Ya-Jing Chen et al.   BRAIN RESEARCH BULLETIN

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

Sarsasapogenin: A steroidal saponin from Asparagus racemosus as multi target directed ligand in Alzheimer’s disease

(2019) Priya Kashyap et al.   STEROIDS

Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link

(2018) Ying Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation

(2018) Wenbao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents

(2018) Gui-Xiang Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brain Cholinergic Markers and Tau Phosphorylation are Altered in Experimental Type 1 Diabetes: Normalization by Electroacupuncture

(2018) Maria Luisa Rocco et al.   JOURNAL OF ALZHEIMERS DISEASE

Sarsasapogenin suppresses Aβ overproduction induced by high glucose in HT-22 cells

(2017) Meng-Ya Zhang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Synthesis and evaluation of 26-amino acid methyl ester substituted sarsasapogenin derivatives as neuroprotective agents for Alzheimer’s disease

(2017) Ze-Dan Wang et al.   STEROIDS

Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells

(2016) Guoqiong Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-  Alterations in a Monkey Model of Type 1 Diabetes

(2016) J. Morales-Corraliza et al.   JOURNAL OF NEUROSCIENCE

Timosaponin B-II ameliorates scopolamine-induced cognition deficits by attenuating acetylcholinesterase activity and brain oxidative damage in mice

(2016) Xu Zhao et al.   METABOLIC BRAIN DISEASE

Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer’s Disease Through Inhibition of BACE1

(2016) Xu Wang et al.   MOLECULAR NEUROBIOLOGY

Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aβ-lowering modulators of amyloid precursor protein processing

(2016) Lai-King Sy et al.   Chemical Science

High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

(2016) Hyun Jik Lee et al.   Scientific Reports

Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes

(2015) Karen A. Nunley et al.   DIABETES CARE

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study

(2015) Kate Smolina et al.   DIABETOLOGIA

Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells

(2015) Nan Lin et al.   MOLECULAR NEUROBIOLOGY

Genetic Ablation of Tau Mitigates Cognitive Impairment Induced by Type 1 Diabetes

(2014) Serena Abbondante et al.   AMERICAN JOURNAL OF PATHOLOGY

Brain Aging and AD-Like Pathology in Streptozotocin-Induced Diabetic Rats

(2014) Jian-Qin Wang et al.   Journal of Diabetes Research

Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats

(2013) Yao-Wu Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Timosaponin-BII inhibits the up-regulation of BACE1 induced by Ferric Chloride in rat retina

(2012) Ju-Fang Huang et al.   BMC Complementary and Alternative Medicine

Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

(2011) Zhongsen Qu et al.   BRAIN RESEARCH

Total saponins from Rhizoma Anemarrhenae ameliorate diabetes-associated cognitive decline in rats: Involvement of amyloid-beta decrease in brain

(2011) Yao-Wu Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Encephalopathies: the emerging diabetic complications

(2010) Anders A. F. Sima   ACTA DIABETOLOGICA

Glycogen synthase kinase-3β, or a link between amyloid and tau pathology?

(2010) D. Muyllaert et al.   GENES BRAIN AND BEHAVIOR

Increased Tau Phosphorylation and Cleavage in Mouse Models of Type 1 and Type 2 Diabetes

(2009) Bhumsoo Kim et al.   ENDOCRINOLOGY

GSK3: A possible link between beta amyloid peptide and tau protein

(2009) Félix Hernández et al.   EXPERIMENTAL NEUROLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice

(2009) Bomi Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Increased amyloid β-peptide (1–40) level in brain of streptozotocin-induced diabetic rats

(2008) Y. Liu et al.   NEUROSCIENCE