Cell–extracellular matrix dynamics

3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain

(2021) Andrew D. Doyle et al.   DEVELOPMENTAL CELL

Enhanced substrate stress relaxation promotes filopodia-mediated cell migration

(2021) Kolade Adebowale et al.   NATURE MATERIALS

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

(2021) Rosemarie E. Gough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics

(2021) Alberto Elosegui-Artola   CURRENT OPINION IN CELL BIOLOGY

Basement Membrane Regulates Fibronectin Organization Using Sliding Focal Adhesions Driven by a Contractile Winch

(2020) Jiaoyang Lu et al.   DEVELOPMENTAL CELL

Basement membrane remodelling regulates mouse embryogenesis

(2020) Christos Kyprianou et al.   NATURE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Durotaxis by Human Cancer Cells

(2019) Brian J. DuChez et al.   BIOPHYSICAL JOURNAL

Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration

(2019) William Y. Wang et al.   Nature Communications

Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs

(2019) Laura C. Kelley et al.   DEVELOPMENTAL CELL

Beyond proteases: Basement membrane mechanics and cancer invasion

(2019) Julie Chang et al.   JOURNAL OF CELL BIOLOGY

High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics

(2019) Jack R. Staunton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns

(2019) Alexandra Fink et al.   BIOPHYSICAL JOURNAL

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

(2019) Robin Ferrari et al.   Nature Communications

Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

(2018) Junzhe Lou et al.   BIOMATERIALS

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

(2018) Ze Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myoepithelial cells are a dynamic barrier to epithelial dissemination

(2018) Orit Katarina Sirka et al.   JOURNAL OF CELL BIOLOGY

Cell–Cell Mechanical Communication in Cancer

(2018) Samantha C. Schwager et al.   Cellular and Molecular Bioengineering

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

Invadosomes are coming: new insights into function and disease relevance

(2017) Elyse K. Paterson et al.   FEBS Journal

The nature and biology of basement membranes

(2017) Ambra Pozzi et al.   MATRIX BIOLOGY

A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix

(2017) Leanna M. Owen et al.   MOLECULAR BIOLOGY OF THE CELL

Integrin extension enables ultrasensitive regulation by cytoskeletal force

(2017) Jing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinculin forms a directionally asymmetric catch bond with F-actin

(2017) Derek L. Huang et al.   SCIENCE

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

(2017) Alexandros Glentis et al.   Nature Communications

Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype

(2017) Shawn P. Carey et al.   Scientific Reports

Strain Stiffening of Fibrillar Collagen during Individual and Collective Cell Migration Identified by AFM Nanoindentation

(2016) Sjoerd van Helvert et al.   ACS Applied Materials & Interfaces

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

(2016) Shelly Kaushik et al.   CANCER AND METASTASIS REVIEWS

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

(2016) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

(2015) Vira V. Artym et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Three-dimensional force microscopy of cells in biopolymer networks

(2015) Julian Steinwachs et al.   NATURE METHODS

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini

(2015) Aljona Gaiko-Shcherbak et al.   PLoS One

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility

(2014) Jill S. Harunaga et al.   DEVELOPMENTAL BIOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Contractile Fibers and Catch-Bond Clusters: a Biological Force Sensor?

(2013) Elizaveta A. Novikova et al.   BIOPHYSICAL JOURNAL

Matrix Microarchitecture and Myosin II Determine Adhesion in 3D Matrices

(2013) Kristopher E. Kubow et al.   CURRENT BIOLOGY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Micro-environmental control of cell migration - myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics

(2012) A. D. Doyle et al.   JOURNAL OF CELL SCIENCE

The Integrin-Ligand Interaction Regulates Adhesion and Migration through a Molecular Clutch

(2012) Lingfeng Chen et al.   PLoS One

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

(2012) Rosa Anna DeFilippis et al.   Cancer Discovery

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Adhesion dynamics at a glance

(2011) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Dynamics Study of Talin-Vinculin Binding

(2008) S.E. Lee et al.   BIOPHYSICAL JOURNAL

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE