A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanosensing via cell-matrix adhesions in 3D microenvironments

(2016) Andrew D. Doyle et al.   EXPERIMENTAL CELL RESEARCH

The inner workings of stress fibers − from contractile machinery to focal adhesions and back

(2016) Ariel Livne et al.   JOURNAL OF CELL SCIENCE

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Mean deformation metrics for quantifying 3D cell–matrix interactions without requiring information about matrix material properties

(2016) David A. Stout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen

(2015) Ingo Thievessen et al.   FASEB JOURNAL

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers

(2015) Jacob Notbohm et al.   Integrative Biology

Microbuckling of fibrin provides a mechanism for cell mechanosensing

(2015) Jacob Notbohm et al.   Journal of the Royal Society Interface

Cellular chirality arising from the self-organization of the actin cytoskeleton

(2015) Yee Han Tee et al.   NATURE CELL BIOLOGY

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Three-dimensional force microscopy of cells in biopolymer networks

(2015) Julian Steinwachs et al.   NATURE METHODS

Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly

(2015) Colleen T. Skau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

(2015) Sari Tojkander et al.   eLife

Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations

(2014) A.S. Abhilash et al.   BIOPHYSICAL JOURNAL

A Fast Iterative Digital Volume Correlation Algorithm for Large Deformations

(2014) E. Bar-Kochba et al.   EXPERIMENTAL MECHANICS

Matrix Confinement Plays a Pivotal Role in Regulating Neutrophil-generated Tractions, Speed, and Integrin Utilization

(2014) Jennet Toyjanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contractile forces regulate cell division in three-dimensional environments

(2014) Ayelet Lesman et al.   JOURNAL OF CELL BIOLOGY

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

3D Viscoelastic traction force microscopy

(2014) Jennet Toyjanova et al.   Soft Matter

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

Measuring Actin Flow in 3D Cell Protrusions

(2013) Chi-Li Chiu et al.   BIOPHYSICAL JOURNAL

Contractile Fibers and Catch-Bond Clusters: a Biological Force Sensor?

(2013) Elizaveta A. Novikova et al.   BIOPHYSICAL JOURNAL

Cells Actively Stiffen Fibrin Networks by Generating Contractile Stress

(2013) Karin A. Jansen et al.   BIOPHYSICAL JOURNAL

Determinants of Maximal Force Transmission in a Motor-Clutch Model of Cell Traction in a Compliant Microenvironment

(2013) Benjamin L. Bangasser et al.   BIOPHYSICAL JOURNAL

Matrix Microarchitecture and Myosin II Determine Adhesion in 3D Matrices

(2013) Kristopher E. Kubow et al.   CURRENT BIOLOGY

Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: Filopod-mediated extension–relaxation cycles and force anisotropy

(2013) Josefine Starke et al.   EXPERIMENTAL CELL RESEARCH

The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration

(2013) Anjil Giri et al.   FASEB JOURNAL

The tension mounts: Stress fibers as force-generating mechanotransducers

(2013) Keith Burridge et al.   JOURNAL OF CELL BIOLOGY

Deconstructing Dimensionality

(2013) M. A. Schwartz et al.   SCIENCE

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

3D Traction Forces in Cancer Cell Invasion

(2012) Thorsten M. Koch et al.   PLoS One

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration

(2012) Shyam B. Khatau et al.   Scientific Reports

A role for actin arcs in the leading-edge advance of migrating cells

(2011) Dylan T. Burnette et al.   NATURE CELL BIOLOGY

Three-Dimensional Traction Force Microscopy: A New Tool for Quantifying Cell-Matrix Interactions

(2011) Christian Franck et al.   PLoS One

Cell Motility and Mechanics in Three-Dimensional Collagen Matrices

(2010) Frederick Grinnell et al.   Annual Review of Cell and Developmental Biology

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Structural Hierarchy Governs Fibrin Gel Mechanics

(2010) Izabela K. Piechocka et al.   BIOPHYSICAL JOURNAL

Transient Frictional Slip between Integrin and the ECM in Focal Adhesions under Myosin II Tension

(2010) Yvonne Aratyn-Schaus et al.   CURRENT BIOLOGY

Reducing background fluorescence reveals adhesions in 3D matrices

(2010) Kristopher E. Kubow et al.   NATURE CELL BIOLOGY

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Direct Comparisons of the Morphology, Migration, Cell Adhesions, and Actin Cytoskeleton of Fibroblasts in Four Different Three-Dimensional Extracellular Matrices

(2010) Kirsi M. Hakkinen et al.   TISSUE ENGINEERING PART A

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Modulation of 3D Fibrin Matrix Stiffness by Intrinsic Fibrinogen–Thrombin Compositions and by Extrinsic Cellular Activity

(2009) Haison Duong et al.   TISSUE ENGINEERING PART A

Mapping Local Matrix Remodeling Induced by a Migrating Tumor Cell Using Three-Dimensional Multiple-Particle Tracking

(2008) Ryan J. Bloom et al.   BIOPHYSICAL JOURNAL

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Tensile forces govern germ-layer organization in zebrafish

(2008) M. Krieg et al.   NATURE CELL BIOLOGY

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow

(2008) Antonina Y. Alexandrova et al.   PLoS One

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE