ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites

Title
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites
Authors
Keywords
Abemaciclib, active metabolites, P-glycoprotein/ABCB1, BCRP/ABCG2, CYP3A, brain penetration, pharmacokinetics
Journal
PHARMACOLOGICAL RESEARCH
Volume -, Issue -, Pages 105954
Publisher
Elsevier BV
Online
2021-10-26
DOI
10.1016/j.phrs.2021.105954

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