ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites
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Title
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites
Authors
Keywords
Abemaciclib, active metabolites, P-glycoprotein/ABCB1, BCRP/ABCG2, CYP3A, brain penetration, pharmacokinetics
Journal
PHARMACOLOGICAL RESEARCH
Volume -, Issue -, Pages 105954
Publisher
Elsevier BV
Online
2021-10-26
DOI
10.1016/j.phrs.2021.105954
References
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