Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo

Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation

(2020) Yuntian Shen et al.   Frontiers in Physiology

STAT3 phosphorylation mediates high glucose–impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy

(2019) Wei Du et al.   FASEB JOURNAL

Diabetes mellitus as a risk factor for intervertebral disc degeneration: a critical review

(2019) Kalliopi Alpantaki et al.   EUROPEAN SPINE JOURNAL

BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration

(2019) Jianle Wang et al.   FASEB JOURNAL

TIGAR impedes compression‐induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy

(2019) Zhiliang Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of autophagy in the retina after optic nerve crush injury in rats

(2019) Li-Hua Kang   International Journal of Ophthalmology

Cyanidin attenuates Aβ25-35-induced neuroinflammation by suppressing NF-κB activity downstream of TLR4/NOX4 in human neuroblastoma cells

(2018) Sarinthorn Thummayot et al.   ACTA PHARMACOLOGICA SINICA

Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells

(2018) Changhong Gao et al.   Aging-US

Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage

(2018) Jinlou Gao et al.   BIOSCIENCE REPORTS

Neuronal autophagy and axon degeneration

(2018) Yu Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyanidin Curtails Renal Cell Carcinoma Tumorigenesis

(2018) Xiaobing Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

(2018) Fang Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model

(2018) Yu Chen et al.   International Journal of Biological Sciences

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

(2018) Jian Chen et al.   Cell Death & Disease

Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice

(2018) Elena Daveri et al.   Redox Biology

Effects of malvidin, cyanidin and delphinidin on human adipose mesenchymal stem cell differentiation into adipocytes, chondrocytes and osteocytes

(2018) Liga Saulite et al.   PHYTOMEDICINE

Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration

(2017) Kangcheng Zhao et al.   GENE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration

(2017) Satoshi Suzuki et al.   SPINE

Mechanism of microRNA-146a-mediated IL-6/STAT3 signaling in lumbar intervertebral disc degeneration

(2017) Tao Zhou et al.   Experimental and Therapeutic Medicine

Effects of cyanidin 3-0-glucoside on cardiac structure and function in an animal model of myocardial infarction

(2017) Pema Raj et al.   Food & Function

Resveratrol attenuated TNF-α–induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway

(2016) Xiao-Hu Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MMPs and ADAMTSs in intervertebral disc degeneration

(2015) Wen-Jun Wang et al.   CLINICA CHIMICA ACTA

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Leptin modulates the expression of catabolic genes in rat nucleus pulposus cells through the mitogen-activated protein kinase and Janus kinase 2/signal transducer and activator of transcription 3 pathways

(2015) DAOYI MIAO et al.   Molecular Medicine Reports

SIRT1 Plays a Protective Role in Intervertebral Disc Degeneration in a Puncture-induced Rodent Model

(2015) Xinlei Xia et al.   SPINE

Grape seed proanthocyanidin protects liver against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

(2015) Zhen-Chao Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy promotes apoptosis of mesenchymal stem cells under inflammatory microenvironment

(2015) Shipeng Dang et al.   Stem Cell Research & Therapy

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

(2014) Y Feng et al.   Cell Death & Disease

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

(2014) Wei Jiang et al.   Scientific Reports

Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways

(2013) Si Gao et al.   CANCER LETTERS

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells

(2010) Je Hoon Jeong et al.   ACTA NEUROCHIRURGICA

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc

(2008) Xin Li et al.   SPINE