Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway

D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy

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Yeast β-D-glucan exerts anti-tumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis

(2020) Ningning Wang et al.   Redox Biology

Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics

(2020) Alia Ghoneum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNAs implications in the onset, diagnosis, and prognosis of osteosarcoma

(2020) Negin Ebrahimi et al.   CURRENT MOLECULAR MEDICINE

Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo

(2019) Min Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes

(2019) Shuna Sun et al.   Cell Death & Disease

Tetrandrine isolated from Cyclea peltata induces cytotoxicity and apoptosis through ROS and caspase pathways in breast and pancreatic cancer cells

(2019) Bhagya N. et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

A decade of clinical development of PARP inhibitors in perspective

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PARP Inhibition in Cancer: An Update on Clinical Development

(2019) Esha Sachdev et al.   Targeted Oncology

NCAPG Promotes The Proliferation Of Hepatocellular Carcinoma Through PI3K/AKT Signaling

(2019) Chengwu Gong et al.   OncoTargets and Therapy

Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway

(2018) Xue-Bin Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Folic acid supplementation repressed hypoxia-induced inflammatory response via ROS and JAK2/STAT3 pathway in human promyelomonocytic cells

(2018) Jing Ma et al.   NUTRITION RESEARCH

Cross Talk Between Autophagy and Apoptosis Contributes to ZnO Nanoparticle-Induced Human Osteosarcoma Cell Death

(2018) Guanping He et al.   Advanced Healthcare Materials

Redox Signaling by Reactive Electrophiles and Oxidants

(2018) Saba Parvez et al.   CHEMICAL REVIEWS

Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?

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Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway

(2018) Xiaoqi Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis

(2018) Yang Wang et al.   Food & Function

Glutathione: subcellular distribution and membrane transport

(2018) Julian Oestreicher et al.   Biochemistry and Cell Biology

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

(2018) Wei Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Long Noncoding RNA FEZF1-AS1 Promotes Proliferation and Inhibits Apoptosis in Ovarian Cancer by Activation of JAK-STAT3 Pathway

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Novel insights and therapeutic interventions for pediatric osteosarcoma

(2017) Leo Kager et al.   Future Oncology

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The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

(2017) Jennifer Huynh et al.   SEMINARS IN CANCER BIOLOGY

Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes

(2017) Feng Cao et al.   BMC Pharmacology & Toxicology

Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells

(2016) Yuan-Jing Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells

(2015) Peiyan Hua et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of oleandrin on the proliferation and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway

(2015) Yunlong Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation

(2015) Xiyu Zhang et al.   Scientific Reports

GSSG/GSH ratios in cryopreserved rat and human hepatocytes as a biomarker for drug induced oxidative stress

(2014) Sonia Sentellas et al.   TOXICOLOGY IN VITRO

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

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Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells

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