Article
Integrative & Complementary Medicine
Jia-Ying Wu, Ying-Jie Chen, Xiu-Qiong Fu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Jing-Xuan Bai, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong, Zhi-Ling Yu
Summary: The study demonstrates that chrysoeriol suppresses the hyperproliferation of RA-FLS and induces apoptosis. This is achieved by inhibiting the JAK2/STAT3 signaling pathway and downregulating the expression of Bcl-2 and Mcl-1.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Oncology
Shixin Chan, Rui Sun, Xucan Tu, Manyu Guo, Qianqian Yuan, Zhen Yu, Zhenglin Wang, Shaocheng Hong, Wei Han, Bingbing Zou, Zeng Li, Huabing Zhang, Wei Chen
Summary: The study demonstrates that rutaecarpine (RUT) can inhibit the proliferation and migration of colorectal cancer cells and induce cell apoptosis by inactivating NF-kappa B/STAT3 signaling pathway. This suggests the potential clinical application of RUT for the treatment of colorectal cancer.
Article
Oncology
Huailin Wang, Yan Fu
Summary: Up-regulation of NR1D1 in ovarian cancer cells inhibits cell proliferation, induces cell cycle arrest and apoptosis, suppresses the JAK/STAT3 signaling pathway through up-regulation of SOCS3, and delays the growth of ovarian cancer cells.
Article
Plant Sciences
Jiong Wang, Chenchen Qian, Yue Chen, Tianyang Jin, Yongsheng Jiang, Lijiang Huang, Xinyan Fu, Dong Yang, Leiming Jin, Bo Jin, Yi Wang
Summary: This study found that ss-elemene preserved the hearts of diabetic mice by inhibiting JAK/STAT3 and NF-kappa B mediated inflammatory responses, suggesting that ss-elemene is an effective therapy for diabetic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Peng Han, Jin Shang, Dan-Ling Chen, Si-Yang Li, Rui Fan, Rui-Han Li, Hui-Qi Li, Shi-Yang Zhang, Dong-Yan Shen
Summary: Baicalein, derived from Scutellaria baicalensis Georgi, shows anticancer effects on cholangiocarcinoma cells by inhibiting cell viability and proliferation, inducing apoptosis and cell cycle arrest, suppressing migration and invasion, reducing aerobic glycolysis, and inhibiting tumor growth through regulating protein expression and signaling pathways both in vitro and in vivo.
PROCESS BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Vimala Karuppaiya, Asaikkutti Annamalai, Shanthi Krishnamurthy, Kannan Soundarapandian
Summary: This study found that the natural substance DCL can inhibit the proliferation and migration of prostate cancer cells by blocking the JAK/STAT3 signaling pathway. The results showed that DCL has significant cytotoxic effects on PC-3 cells and can increase ROS production and apoptotic signals. Additionally, DCL suppresses the expression of proteins that control cell proliferation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Luya Pu, Qingyu Meng, Shuai Li, Bin Liu, Fan Li
Summary: Icariin can inhibit the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, indicating its potential for the treatment of RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Qoyama Noel Baito, Halmat M. Jaafar, Talar Ahmad Merza Mohammad
Summary: In this study, piperine was found to induce apoptosis and reduce proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) through inhibition of the NF-kappa B pathway. It also decreased the expression of genes related to RA-FLS proliferation, apoptosis inhibition, and inflammation, while increasing the expression of apoptosis-related genes. Moreover, piperine reduced the secretion of cytokines and chemokines by FLSs as a result of NF-kappa B inhibition.
CELLULAR IMMUNOLOGY
(2023)
Article
Mathematical & Computational Biology
Vidisha Singh, Aurelien Naldi, Sylvain Soliman, Anna Niarakis
Summary: Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) play a significant role in initiating and perpetuating destructive joint inflammation. RA-FLS-directed therapies could become a complementary approach to immune-directed therapies by predicting optimal conditions that limit inflammation and minimize bone erosion and cartilage destruction.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Developmental Biology
Qing Zuo, Yanfeng Zou, Shiyun Huang, Tianjun Wang, Yetao Xu, Tingting Zhang, Min Zhang, Zhiping Ge, Ziyan Jiang
Summary: Aspirin reduces trophoblast apoptosis in preeclampsia by inactivating the NF-kappa B signaling pathway and reversing endothelial dysfunction and oxidative stress caused by sFlt-1. This treatment significantly improves the condition of patients with preeclampsia.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Pharmacology & Pharmacy
Jian Chen, Xian Lin, Kangdi Liu, Juan He, Xin Li, Chuchu Zhang, Yongxing Deng, Lianxiang Luo, Cheng Tao, Qingwen Wang
Summary: This study demonstrated that a novel compound CT2-3 inhibits the abnormal functions of RA-fibroblastlike synoviocytes (RA-FLSs) by inducing cell cycle arrest and apoptosis through modulating the PI3K/AKT pathway, offering a potential lead compound for the development of novel anti-RA drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Rheumatology
S. Wu, Y. Jiang, Y. Teng, X. Liu, L. Zhou, W. Li
Summary: IL-33 inhibits apoptosis and promotes proliferation of RA FLSs, increases the expression levels of Bcl-2 protein and decreases the expression levels of Bax protein. Additionally, IL-33 enhances the expression levels of inflammatory cytokines TNF-alpha and IL-6 through the NF-kappa B pathway.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Immunology
Mehrnoosh Adib, Mahdi Taghadosi, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhadi
Summary: This study investigates the effects of PRIMA-1(MET) on apoptosis induction and inhibition of pro-inflammatory cytokines in fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA). The results show that PRIMA-1(MET) induces apoptosis in RA-FLSs, upregulates Noxa expression, and downregulates IL-6, IL-1β, p53, and phospho-IKBa expression. Furthermore, PRIMA-1(MET) treatment suppresses pro-inflammatory cytokine production and inhibits NF-kappa B activity. Therefore, PRIMA-1(MET) could be considered as a new therapeutic strategy for rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Chenchen Liu, Wei Zhao, Jia Su, Xiaochun Chen, Feifan Zhao, Jindai Fan, Xiaowen Li, Xiaodi Liu, Linke Zou, Mengru Zhang, Zilin Zhang, Liangliang Zhang, Shuangqi Fan, Yuwan Li, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: Heat shock protein HSP90AA1 plays an important role in classical swine fever virus (CSFV) infection by inhibiting viral replication and activating JAK/STAT and NF-κB signaling pathways through interaction with NS5A protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoqi Zhang, Hao Feng, Dongfang Li, Shanshan Liu, Norio Amizuka, Minqi Li
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Genetics & Heredity
Feng Liu, Lu Xing, Xiaoqian Zhang, Xiaoqi Zhang
Article
Biochemistry & Molecular Biology
Lu Xing, Xiaoqi Zhang, Hao Feng, Shanshan Liu, Dongfang Li, Tomoka Hasegawa, Jie Guo, Minqi Li
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Lu Xing, Xiaoqi Zhang, Mingzhu Guo, Xiaoqian Zhang, Feng Liu
DNA AND CELL BIOLOGY
(2020)
Article
Oncology
Lu Xing, Mingzhu Guo, Xiaoqi Zhang, Xiaoqian Zhang, Feng Liu
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Cell Biology
Lu Xing, Xiaoqi Zhang, Xiaoqian Zhang, Dongdong Tong
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Hao Feng, Xiaoqi Zhang, Wenli Lai, Jian Wang
Article
Immunology
Xiaoqi Zhang, Linghuan Ren, Xinyu Yan, Yue Shan, Lu Liu, Jing Zhou, Qianyun Kuang, Minqi Li, Hu Long, Wenli Lai
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Xiaoqi Zhang, Qingxuan Wang, Xinyu Yan, Yue Shan, Lu Xing, Minqi Li, Hu Long, Wenli Lai
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Biology
Yue Shan, Han Han, Jingyi Zhu, Xinyu Yan, Xiaoqi Zhang, Hu Long, Fan Jian, Xiaolong Li, Yan Wang, Wenli Lai
Summary: The study demonstrated that the application of static magnetic field (SMF) can accelerate orthodontic tooth movement in mice by enhancing the rate and cumulative amount of tooth movement, increasing the width of periodontal ligament (PDL), promoting earlier formation and removal of the hyalinized zone, and increasing the number of osteoclasts.
BIOELECTROMAGNETICS
(2021)
Article
Medicine, General & Internal
Xinyu Yan, Xiaoqi Zhang, Yiyin Chen, Hu Long, Wenli Lai
Summary: This study aimed to evaluate the association between upper lip characteristics (ULCs) and skeletal patterns (SPs) in 2079 patients. Results showed significant variations in ULCs among different SPs, with superior sulcus depth being independently associated with SPs. Adjustment for confounders revealed superior sulcus depth as the only ULC significantly corrected by intervention of skeletal growth.
Article
Dentistry, Oral Surgery & Medicine
Lu Liu, Qinxuan Song, Jing Zhou, Qianyun Kuang, Xinyu Yan, Xiaoqi Zhang, Yue Shan, Xiaolong Li, Hu Long, Wenli Lai
Summary: This study analyzed the effects of aligner overtreatment on torque control and incisor intrusion during anterior retraction. The results showed that clear aligner therapy caused lingual tipping, extrusion, and intrusion of teeth. Canine attachments enhanced these effects and required more support from posterior teeth. Appropriate overtreatment with attachments can achieve incisor intrusion and palatal root torquing.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lu Xing, Xiaoqi Zhang, Yongwen Guo, Ding Bai, Hui Xu
Summary: A machine learning-based study was conducted to predict lip prominence. The XGBoost model performed the best in predicting the distances between lips and the esthetics plane. The L1-NB distance contributed the most to lip prominence. The results can be used in orthodontic treatment planning.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Maierdanjiang Rouzi, Xiaoqi Zhang, Qingsong Jiang, Hu Long, Wenli Lai, Xiaolong Li
Summary: The demand for clear aligners has increased due to their less noticeable and comfortable nature. Research has shown that clear aligners have no significant impact on the oral microbiome, while demonstrating positive results in terms of plaque control and gingival health. However, grooves and abrasions on aligner surfaces may provide a favorable environment for bacterial adherence and plaque biofilm development.
INTERNATIONAL DENTAL JOURNAL
(2023)