Broadening the reach and investigating the potential of prime editors through fully viral gene-deleted adenoviral vector delivery

Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq

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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

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Dual-AAV delivering split prime editor system for in vivo genome editing

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Adenovirus – a blueprint for gene delivery

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Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases

(2021) Hyewon Jang et al.   Nature Biomedical Engineering

Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53

(2020) Toshinori Hyodo et al.   Cell Reports

High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy

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High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells

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Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

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Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

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The stability of envelope-pseudotyped lentiviral vectors

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Predicting the efficiency of prime editing guide RNAs in human cells

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Precise and broad scope genome editing based on high-specificity Cas9 nickases

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CRISPResso2 provides accurate and rapid genome editing sequence analysis

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Adenovirus Entry: From Infection to Immunity

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Search-and-replace genome editing without double-strand breaks or donor DNA

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Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

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Precise and efficient nucleotide substitution near genomic nick via noncanonical homology-directed repair

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In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting

(2017) Xiaoyu Chen et al.   Nature Communications

Engineered Viruses as Genome Editing Devices

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Probing the impact of chromatin conformation on genome editing tools

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Development of an intein-mediated split–Cas9 system for gene therapy

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Construction and characterization of adenoviral vectors for the delivery of TALENs into human cells

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Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence

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Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

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Adenoviral vector DNA for accurate genome editing with engineered nucleases

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CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

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Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

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DNA targeting specificity of RNA-guided Cas9 nucleases

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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

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Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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LINE-1 Elements in Structural Variation and Disease

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Transcription Factor Rational Design Improves Directed Differentiation of Human Mesenchymal Stem Cells Into Skeletal Myocytes

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Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

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A rapid protocol for construction and production of high-capacity adenoviral vectors

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Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

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Protein Trans-Splicing as a Means for Viral Vector-Mediated In Vivo Gene Therapy

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Genetic Complementation of Human Muscle Cells via Directed Stem Cell Fusion

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Serum-free transient protein production system based on adenoviral vector and PER.C6 technology: High yield and preserved bioactivity

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