Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases

Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial

(2015) K. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease

(2015) Gabriela Fonseca-Camarillo et al.   CYTOKINE

IL-4 and IL-13 signaling in allergic airway disease

(2015) Naina Gour et al.   CYTOKINE

The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases

(2015) Jennifer Palomo et al.   CYTOKINE

Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases

(2015) Suzanne Devkota et al.   DIGESTIVE DISEASES

Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice

(2015) Elisa Montaldo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial

(2015) Paul Moayyedi et al.   GASTROENTEROLOGY

Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage

(2015) Xinyang Song et al.   IMMUNITY

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis

(2015) Thibault Griseri et al.   IMMUNITY

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine

(2015) O J Harrison et al.   Mucosal Immunology

Clinical improvement in psoriasis with specific targeting of interleukin-23

(2015) Tamara Kopp et al.   NATURE

Biologic agents for IBD: practical insights

(2015) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis

(2015) Italia Loddo et al.   Frontiers in Immunology

Antibiotics Associated With Increased Risk of New-Onset Crohn’s Disease But Not Ulcerative Colitis: A Meta-Analysis

(2014) Ryan Ungaro et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Overexpression of GATA-3 in T Cells Accelerates Dextran Sulfate Sodium-Induced Colitis

(2014) Midori Okamura et al.   EXPERIMENTAL ANIMALS

Cellular sources of IL-17 in psoriasis: a paradigm shift?

(2014) Romy R. M. C. Keijsers et al.   EXPERIMENTAL DERMATOLOGY

Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study

(2014) Silvio Danese et al.   GUT

IL-9 and its receptor are predominantly involved in the pathogenesis of UC

(2014) Nancy Nalleweg et al.   GUT

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Inflammatory Bowel Disease as a Model for Translating the Microbiome

(2014) Curtis Huttenhower et al.   IMMUNITY

Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice

(2014) Marion T. Kasaian et al.   IMMUNOLOGY

Induction of Bacterial Antigen-Specific Colitis by a Simplified Human Microbiota Consortium in Gnotobiotic Interleukin-10-/- Mice

(2014) C. S. Eun et al.   INFECTION AND IMMUNITY

Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

(2014) Wenyu Jiang et al.   INFLAMMATION RESEARCH

Molecular Patterns in Human Ulcerative Colitis and Correlation with Response to Infliximab

(2014) Brendan Halloran et al.   INFLAMMATORY BOWEL DISEASES

Human Gut Dendritic Cells Drive Aberrant Gut-specific T-cell Responses in Ulcerative Colitis, Characterized by Increased IL-4 Production and Loss of IL-22 and IFNγ

(2014) Elizabeth R. Mann et al.   INFLAMMATORY BOWEL DISEASES

Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis

(2014) Ruben J. Colman et al.   Journal of Crohns & Colitis

Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35

(2014) E. Bardel et al.   JOURNAL OF IMMUNOLOGY

NFIL3-Deficient Mice Develop Microbiota-Dependent, IL-12/23-Driven Spontaneous Colitis

(2014) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Fecal Microbiota Transplantation in Inflammatory Bowel Disease

(2014) Gianluca Ianiro et al.   MEDICINE

Life of T Follicular Helper Cells

(2014) Woong-Kyung Suh   MOLECULES AND CELLS

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

(2014) Katharina Gerlach et al.   NATURE IMMUNOLOGY

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

(2013) A. M. Pesenacker et al.   BLOOD

T helper cells plasticity in inflammation

(2013) Lorenzo Cosmi et al.   CYTOMETRY PART A

Endotoxicity of Lipopolysaccharide as a Determinant of T-Cell−Mediated Colitis Induction in Mice

(2013) Kerstin Gronbach et al.   GASTROENTEROLOGY

Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients

(2013) Aito Ueno et al.   INFLAMMATORY BOWEL DISEASES

Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines

(2013) Christoph Spiess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines

(2013) M. J. Rosen et al.   JOURNAL OF IMMUNOLOGY

IL-17 and TNF Synergistically Modulate Cytokine Expression while Suppressing Melanogenesis: Potential Relevance to Psoriasis

(2013) Claire Q.F. Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma

(2013) Chad K Oh et al.   RESPIRATORY RESEARCH

Identity crisis of Th17 cells: Many forms, many functions, many questions

(2013) Mark S. Sundrud et al.   SEMINARS IN IMMUNOLOGY

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study

(2012) P. Rich et al.   BRITISH JOURNAL OF DERMATOLOGY

Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study

(2012) K.A. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

Helper T cell diversity and plasticity

(2012) Shingo Nakayamada et al.   CURRENT OPINION IN IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

(2012) Ana Camelo et al.   JOURNAL OF GASTROENTEROLOGY

Cutting Edge: Regulation of Intestinal Inflammation and Barrier Function by IL-17C

(2012) Joseph M. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

(2012) Giovanni Monteleone et al.   MOLECULAR THERAPY

Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease

(2012) D Ishikawa et al.   Mucosal Immunology

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

(2012) Janelle S Ayres et al.   NATURE MEDICINE

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation

(2011) Trine Olsen et al.   CYTOKINE

B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice

(2011) Jennifer C. Hoving et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF  treatment

(2011) C. Veltkamp et al.   GUT

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Expression of CD4+ forkhead box P3 (FOXP3)+ regulatory T cells in inflammatory bowel disease

(2011) Yi WANG et al.   Journal of Digestive Diseases

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Peripheral education of the immune system by colonic commensal microbiota

(2011) Stephanie K. Lathrop et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

(2010) M. NIESSNER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

(2010) Zaruhi Hovhannisyan et al.   GASTROENTEROLOGY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Regulatory T cells and inhibitory cytokines in autoimmunity

(2009) Maria Bettini et al.   CURRENT OPINION IN IMMUNOLOGY

Effects of active and passive smoking on disease course of Crohnʼs disease and ulcerative colitis

(2009) Frans van der Heide et al.   INFLAMMATORY BOWEL DISEASES

Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study

(2009) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis

(2009) Pallavi Gupta et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Foxp3+ Regulatory T Cells, Th17 Effector Cells, and Cytokine Environment in Inflammatory Bowel Disease

(2009) Nicola Eastaff-Leung et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Usefulness of CD4+CD45RBhigh CD25− Cell–Transferred SCID Mice for Preclinical Evaluation of Drugs for Inflammatory Bowel Disease

(2009) Daisuke Hirano et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation

(2009) Amit Awasthi et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

(2008) Alejandro V. Villarino et al.   INTERNATIONAL IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease

(2007) Steven T. Leach et al.   INFLAMMATORY BOWEL DISEASES