Therapeutic activity of an interleukin-4/interleukin-13 dual antagonist on oxazolone-induced colitis in mice

Efficacy and Safety of Lebrikizumab in Severe Uncontrolled Asthma: Results from the Lute and Verse Phase II Randomized, Double-Blind, Placebo-Controlled Trials

(2014) Nicola A. Hanania et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

OP011 Tralokinumab (CAT-354), an interleukin 13 antibody, in moderate to severe ulcerative colitis: A phase 2 randomized placebo-controlled study

(2014) S. Danese et al.   Journal of Crohns & Colitis

P516 Discrepancy between fecal biomarkers and their intestinal gene expression in ulcerative colitis: Results from an anti-IL-13 antibody study

(2014) W. Reinisch et al.   Journal of Crohns & Colitis

An IL-4/IL-13 Dual Antagonist Reduces Lung Inflammation, Airway Hyperresponsiveness, and IgE Production in Mice

(2013) Marion T. Kasaian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of eotaxin-3/CC chemokine ligand 26 expression by T helper type 2 cytokines in human colonic myofibroblasts

(2013) K. Takahashi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Anti-IL-13 in Inflammatory Bowel Disease: From the Bench to the Bedside

(2013) Manol Jovani et al.   CURRENT DRUG TARGETS

Interleukin-33 exacerbates acute colitis via interleukin-4 in mice

(2013) Peter N. Pushparaj et al.   IMMUNOLOGY

STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines

(2013) M. J. Rosen et al.   JOURNAL OF IMMUNOLOGY

Interleukin-13 and transforming growth factor β synergise in the pathogenesis of human intestinal fistulae

(2012) Michael Scharl et al.   GUT

Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13

(2012) Ana Camelo et al.   JOURNAL OF GASTROENTEROLOGY

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis

(2011) Matthias A. Engel et al.   DIGESTIVE AND LIVER DISEASE

Calprotectin, Calgranulin C, and Other Members of the S100 Protein Family in Inflammatory Bowel Disease

(2011) Anastassios C. Manolakis et al.   DIGESTIVE DISEASES AND SCIENCES

B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice

(2011) Jennifer C. Hoving et al.   GASTROENTEROLOGY

STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction

(2011) Michael J. Rosen et al.   INFLAMMATORY BOWEL DISEASES

Suppression of inflammation in ulcerative colitis by interferon- -1a is accompanied by inhibition of IL-13 production

(2010) P. J. Mannon et al.   GUT

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Changes Associated with Resistance to Intravenous Corticosteroid Therapy in Children with Severe Ulcerative Colitis

(2010) Boyko Kabakchiev et al.   PLoS One

Transcript levels of different cytokines and chemokines correlate with clinical and endoscopic activity in ulcerative colitis

(2009) Alexandra Zahn et al.   BMC GASTROENTEROLOGY

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

(2009) I. Arijs et al.   GUT

Elevated IL-13Rα2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway

(2009) Debasmita Mandal et al.   INFLAMMATORY BOWEL DISEASES

Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection

(2009) De'Broski R. Herbert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infliximab therapy decreases the levels of TNF-α and IFN-γ mRNA in colonic mucosa of ulcerative colitis

(2009) Trine Olsen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

IL-13 as a therapeutic target for respiratory disease

(2008) Marion T. Kasaian et al.   BIOCHEMICAL PHARMACOLOGY

A Critical Role of CD30 Ligand/CD30 in Controlling Inflammatory Bowel Diseases in Mice

(2008) Xun Sun et al.   GASTROENTEROLOGY

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

(2008) C L Noble et al.   GUT

The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis

(2008) Benno Weigmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function

(2008) F Heller et al.   Mucosal Immunology

Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis

(2008) P. A. KNIGHT et al.   PARASITOLOGY

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

(2008) M. Wills-Karp et al.   Science Signaling