Dysfunction of the blood–brain barrier in Alzheimer's disease: Evidence from human studies

Mediators of cerebral hypoperfusion and blood‐brain barrier leakiness in Alzheimer’s disease, vascular dementia and mixed dementia

(2021) Hannah Tayler et al.   BRAIN PATHOLOGY

Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease

(2021) Rashi I. Mehta et al.   RADIOLOGY

Blood–Brain Barrier Breakdown in Relationship to Alzheimer and Vascular Disease

(2021) Zixuan Lin et al.   ANNALS OF NEUROLOGY

Exploring the changes of brain immune microenvironment in Alzheimer’s disease based on PANDA algorithm combined with blood brain barrier injury-related genes

(2021) Shiting Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pseudogene ACTBP2 increases blood–brain barrier permeability by promoting KHDRBS2 transcription through recruitment of KMT2D/WDR5 in Aβ1–42 microenvironment

(2021) Qianshuo Liu et al.   Cell Death Discovery

APOE4 Accelerates Development of Dementia After Stroke

(2020) Axel Montagne et al.   STROKE

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Noninvasive hippocampal blood−brain barrier opening in Alzheimer’s disease with focused ultrasound

(2020) Ali R. Rezai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer’s microenvironment

(2020) Qianshuo Liu et al.   RNA Biology

Loss of Capillary Pericytes and the Blood‐Brain Barrier in White Matter in Post‐Stroke and Vascular Dementias and Alzheimer’s Disease

(2020) Ren Ding et al.   BRAIN PATHOLOGY

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

(2020) Joel W. Blanchard et al.   NATURE MEDICINE

Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease

(2020) Tunahan Kirabali et al.   BRAIN PATHOLOGY

Abundance of P‐Glycoprotein and Other Drug Transporters at the Human Blood‐Brain Barrier in Alzheimer’s Disease: A Quantitative Targeted Proteomic Study

(2020) Flavia Storelli et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease

(2020) Pierre-François D’Haese et al.   Frontiers in Human Neuroscience

ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease

(2020) Maria Fe Lanfranco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

(2019) Whitney M. Freeze et al.   STROKE

Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals

(2019) Ida Juul Rasmussen et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

IgG transport increases in an in vitro blood‐brain barrier model with Amyloid‐β and with neuroinflammatory cytokines

(2019) Jennifer L. Mantle et al.   BIOTECHNOLOGY AND BIOENGINEERING

Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition

(2019) Montse Solé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid beta 25‐35 impairs docosahexaenoic acid efflux by down‐regulating fatty acid transport protein 1 ( FATP 1/ SLC 27A1) protein expression in human brain capillary endothelial cells

(2019) Yusuke Ochiai et al.   JOURNAL OF NEUROCHEMISTRY

Small vessel disease: mechanisms and clinical implications

(2019) Joanna M Wardlaw et al.   LANCET NEUROLOGY

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro

(2019) Roberta Dal Magro et al.   Frontiers in Neuroscience

miR-424–5p maybe regulate blood-brain barrier permeability in a model in vitro with Abeta incubated endothelial cells

(2019) Meiqing Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model

(2019) Simona Federica Spampinato et al.   Frontiers in Cellular Neuroscience

Glymphatics visualization after focused ultrasound induced blood‐brain barrier opening in humans

(2019) Ying Meng et al.   ANNALS OF NEUROLOGY

CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology

(2019) J. S. Miners et al.   Alzheimers Research & Therapy

Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease

(2019) Ying Meng et al.   NEUROIMAGE

Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

(2019) Joost M. Riphagen et al.   NEUROBIOLOGY OF AGING

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

(2018) Nazira J. Albargothy et al.   ACTA NEUROPATHOLOGICA

Somatostatin Maintains Permeability and Integrity of Blood-Brain Barrier in β-Amyloid Induced Toxicity

(2018) Seungil Paik et al.   MOLECULAR NEUROBIOLOGY

Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis

(2018) Donghui Zhu et al.   MOLECULAR NEUROBIOLOGY

The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier

(2018) Shino Magaki et al.   NEUROBIOLOGY OF AGING

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

(2018) Holly M. Brothers et al.   Frontiers in Aging Neuroscience

The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections

(2018) Jessica Maiuolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spreading of Amyloid, Tau, and Microvascular Pathology in Alzheimer's Disease: Findings from Neuropathological and Neuroimaging Studies

(2018) Dietmar Rudolf Thal et al.   JOURNAL OF ALZHEIMERS DISEASE

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

(2018) Per Kristian Eide et al.   Scientific Reports

In vivo Imaging of Glial Activation in Alzheimer's Disease

(2018) Paul Edison et al.   Frontiers in Neurology

Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease

(2018) Kirsty E. McAleese et al.   BRAIN PATHOLOGY

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

(2018) Qingyi Ma et al.   Molecular Neurodegeneration

Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions

(2018) Karin M. E. Forsberg et al.   Acta Neuropathologica Communications

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease

(2017) J Scott Miners et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes contribute to Aβ-induced blood-brain barrier damage through activation of endothelial MMP9

(2017) Simona Federica Spampinato et al.   JOURNAL OF NEUROCHEMISTRY

Human Truncated Tau is Using a Different Mechanism from Amyloid-β to Damage the Blood-Brain Barrier

(2017) Andrej Kovac et al.   JOURNAL OF ALZHEIMERS DISEASE

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Deposition of amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy

(2016) Abby Keable et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts

(2016) Zoe Arvanitakis et al.   BRAIN PATHOLOGY

MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1

(2016) Wenjing Liu et al.   EXPERIMENTAL CELL RESEARCH

Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

(2016) Cristina Merino-Zamorano et al.   JOURNAL OF ALZHEIMERS DISEASE

Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro

(2016) Kevin P Koster et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood-brain barrier

(2016) Elisanne A.L.M. Biemans et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Is cerebral glucose metabolism related to blood–brain barrier dysfunction and intrathecal IgG synthesis in Alzheimer disease?

(2016) Agostino Chiaravalloti et al.   MEDICINE

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Total Magnetic Resonance Imaging Burden of Small Vessel Disease in Cerebral Amyloid Angiopathy

(2016) Andreas Charidimou et al.   JAMA Neurology

Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier

(2016) Jarred M. Griffin et al.   PLoS One

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD

(2015) Montse Solé et al.   NEUROBIOLOGY OF AGING

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Cerebral small vessel disease and Alzheimer’s disease

(2015) Zhiyou Cai et al.   Clinical Interventions in Aging

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood–brain barrier model

(2014) Hisham Qosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endothelial Cells and Human Cerebral Small Vessel Disease

(2014) Atticus H. Hainsworth et al.   BRAIN PATHOLOGY

Blood-Brain Barrier Dysfunction and Cerebral Small Vessel Disease (Arteriolosclerosis) in Brains of Older People

(2014) Leslie R. Bridges et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Activity of P-Glycoprotein, a  -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

(2014) A. K. Deo et al.   JOURNAL OF NUCLEAR MEDICINE

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Blood–brain-barriers in aging and in Alzheimer’s disease

(2013) Fernanda Marques et al.   Molecular Neurodegeneration

Increased frequency of T cells expressing IL-10 in Alzheimer disease but not in late-onset depression patients

(2013) Karen Cecília Torres et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Deciphering Alzheimer Disease

(2013) D. Selkoe et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness

(2012) Rui Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation

(2012) Xiao-Hong Li et al.   NEUROMOLECULAR MEDICINE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

(2012) Daniëlle ME van Assema et al.   EJNMMI Research

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

ABCB1 Genotype and CSF β-Amyloid in Alzheimer Disease

(2011) R. Kohen et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Vascular pathology in the aged human brain

(2010) Lea Tenenholz Grinberg et al.   ACTA NEUROPATHOLOGICA

ABC efflux transporters in brain vasculature of Alzheimer's subjects

(2010) Hasini C. Wijesuriya et al.   BRAIN RESEARCH

Blood-brain barrier and cerebral small vessel disease

(2010) J.M. Wardlaw   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

(2009) Justin Zaghi et al.   ACTA NEUROPATHOLOGICA

Amyloid   Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

(2009) M. Li et al.   JOURNAL OF IMMUNOLOGY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for A 1-40 Peptides

(2009) H. Xiong et al.   JOURNAL OF NEUROSCIENCE

Blood–brain barrier permeability in Alzheimer's disease: a case–control MRI study

(2009) John M. Starr et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

(2008) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Evidence for Altered LRP/RAGE Expression in Alzheimer Lesion Pathogenesis

(2008) Brian Jeynes et al.   Current Alzheimer Research

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes

(2008) Sabrina Utter et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING