Effects of Chronic Arginase Inhibition with Norvaline on Tau Pathology and Brain Glucose Metabolism in Alzheimer's Disease Mice

Alzheimer’s disease as a chronic maladaptive polyamine stress response

(2021) Baruh Polis et al.   Aging-US

A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease

(2021) Natalia Kyrtata et al.   Frontiers in Neuroscience

Towards a Consensus on Alzheimer’s Disease Comorbidity?

(2021) Iska Avitan et al.   Journal of Clinical Medicine

Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer’s Disease Mice

(2020) Baruh Polis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes

(2020) Christian J. Malpica-Nieves et al.   AMINO ACIDS

18F-FDG-PET Detects Drastic Changes in Brain Metabolism in the Tg4–42 Model of Alzheimer’s Disease

(2019) Caroline Bouter et al.   Frontiers in Aging Neuroscience

Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262

(2019) Taro Saito et al.   HUMAN MOLECULAR GENETICS

18F-FDG Is a Superior Indicator of Cognitive Performance Compared to 18F-Florbetapir in Alzheimer’s Disease and Mild Cognitive Impairment Evaluation: A Global Quantitative Analysis

(2019) Mohsen Khosravi et al.   JOURNAL OF ALZHEIMERS DISEASE

Activated peripheral blood mononuclear cell mediators trigger astrocyte reactivity

(2019) Bruna Bellaver et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models

(2019) Hang Wu et al.   LIFE SCIENCES

Insulin transport into the brain

(2018) Sarah M. Gray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

(2018) Huajie Li et al.   BIOSCIENCE REPORTS

The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke

(2018) Qingqing Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balb/c Mice Fed a High-Fat Diet

(2018) Dana Atrahimovich et al.   Oxidative Medicine and Cellular Longevity

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer’s Disease

(2018) Baruh Polis et al.   Neurotherapeutics

WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit

(2017) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer’s disease

(2017) Shuang-shuang Yang et al.   Translational Neurodegeneration

Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise

(2016) Marcus Moberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum

(2016) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Arginine-induced insulin secretion in endoplasmic reticulum

(2015) Makoto Umeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2015) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease

(2015) Matthew J. Kan et al.   JOURNAL OF NEUROSCIENCE

Insulin secretion stimulated by l-arginine and its metabolite l-ornithine depends on Gαi2

(2014) Veronika Leiss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse

(2014) I.R. Macdonald et al.   Current Alzheimer Research

Cdk5 activity in the brain - multiple paths of regulation

(2014) K. Shah et al.   JOURNAL OF CELL SCIENCE

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Arginase and Arginine Decarboxylase – Where Do the Putative Gate Keepers of Polyamine Synthesis Reside in Rat Brain?

(2013) Daniela Peters et al.   PLoS One

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease

(2013) Harsh Sancheti et al.   PLoS One

Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats

(2013) Xinjuan Li et al.   Neuroscience Bulletin

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase 5 regulates glucose uptake and insulin action in muscle cells

(2012) Suryaprakash Raichur et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Role of phosphorylation in progesterone receptor signaling and specificity

(2011) Christy R. Hagan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting HDACs: A Promising Therapy for Alzheimer's Disease

(2011) Ke Xu et al.   Oxidative Medicine and Cellular Longevity

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

(2010) Rachel M. Nicholson et al.   BRAIN RESEARCH

Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline

(2009) Xiu-Fen Ming et al.   BMC Cardiovascular Disorders

The proline-rich domain of tau plays a role in interactions with actin

(2009) Hai He et al.   BMC CELL BIOLOGY

Targeting Cdk5 Activity in Neuronal Degeneration and Regeneration

(2009) Jyotshnabala Kanungo et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The facilitative glucose transporter GLUT3: 20 years of distinction

(2008) Ian A. Simpson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES