Psychosis in Alzheimer disease — mechanisms, genetics and therapeutic opportunities

Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer’s disease

(2021) Maurits Johansson et al.   Translational Psychiatry

Mild Behavioral Impairment and Subjective Cognitive Decline Predict Cognitive and Functional Decline

(2021) Zahinoor Ismail et al.   JOURNAL OF ALZHEIMERS DISEASE

Low dose lithium treatment of behavioral complications in Alzheimer's disease: Lit-AD randomized clinical trial

(2021) D.P. Devanand et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Agitation in Alzheimer's disease: Novel outcome measures reflecting the International Psychogeriatric Association (IPA) agitation criteria

(2021) Adelaide De Mauleon et al.   Alzheimers & Dementia

Plasma β-Amyloid in Mild Behavioural Impairment – Neuropsychiatric Symptoms on the Alzheimer’s Continuum

(2021) Ruxin Miao et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

(2021) Mary Ann A. DeMichele-Sweet et al.   MOLECULAR PSYCHIATRY

Association between risk of dementia and very late-onset schizophrenia-like psychosis: a Swedish population-based cohort study

(2021) J. Stafford et al.   PSYCHOLOGICAL MEDICINE

Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals

(2020) Firoza Z. Lussier et al.   Alzheimers & Dementia

Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

(2020) Ehsan Pishva et al.   NEUROBIOLOGY OF AGING

Neuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review

(2020) Evangelia Martin et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Challenging our beliefs about delusional disorder in late life

(2020) Maria I. Lapid et al.   INTERNATIONAL PSYCHOGERIATRICS

Neuropsychiatric symptoms in cognitively normal older persons, and the association with Alzheimer’s and non-Alzheimer’s dementia

(2020) Tau Ming Liew   Alzheimers Research & Therapy

Plasma Neurofilament Light: A Marker of Neurodegeneration in Mild Behavioral Impairment

(2020) James P. Naude et al.   JOURNAL OF ALZHEIMERS DISEASE

Trends in Antipsychotic and Mood Stabilizer Prescribing in Long-Term Care in the U.S.: 2011–2014

(2020) Lauren B. Gerlach et al.   Journal of the American Medical Directors Association

Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis

(2020) Clive G. Ballard et al.   PARKINSONISM & RELATED DISORDERS

The Relationship between Neuropsychiatric Symptoms and Default-Mode Network Connectivity in Alzheimer’s Disease

(2020) Jung Suk Lee et al.   Psychiatry Investigation

Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis

(2020) Jennifer A. Watt et al.   BMC Geriatrics

Criteria for Psychosis in Major and Mild Neurocognitive Disorders: International Psychogeriatric Association (IPA) Consensus Clinical and Research Definition

(2020) Jeffrey Cummings et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults

(2020) Yvette I. Sheline et al.   NEUROLOGY

Cognitive profile of mild behavioral impairment (MBI) in brain health registry participants

(2020) Farzeen Kassam et al.   Alzheimers & Dementia

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

(2019) Janina Krell-Roesch et al.   Translational Psychiatry

Discrete effect of each mild behavioural impairment category on dementia conversion or cognitive decline in patients with mild cognitive impairment

(2019) Yuma Yokoi et al.   Psychogeriatrics

Symptom Clusters of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Their Comparative Risks of Dementia: A Cohort Study of 8530 Older Persons

(2019) Tau Ming Liew   Journal of the American Medical Directors Association

Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults

(2019) Byron Creese et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Effects of Vitamin D Use on Outcomes of Psychotic Symptoms in Alzheimer's disease Patients

(2019) Lirong Wang et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Delusions in Alzheimer Disease are Associated With Decreased Default Mode Network Functional Connectivity

(2019) Winnie Qian et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Do Acetylcholinesterase Inhibitors Prevent or Delay Psychotropic Prescribing in People With Dementia? Analyses of the Swedish Dementia Registry

(2019) Edwin C.K. Tan et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Delusional Misidentification of the Mirror Image

(2019) David M. Roane et al.   Current Neurology and Neuroscience Reports

An Australian study of delusional disorder in late life

(2019) Janani Nagendra et al.   INTERNATIONAL PSYCHOGERIATRICS

Prevalence of Mild Behavioral Impairment and Risk of Dementia in a Psychiatric Outpatient Clinic

(2019) Teruyuki Matsuoka et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuropsychiatric Symptoms and Risk of Progression to Alzheimer’s Disease Among Mild Cognitive Impairment Subjects

(2019) Simon Dietlin et al.   JOURNAL OF ALZHEIMERS DISEASE

Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease

(2019) Eun Jin Yoon et al.   NEUROLOGY

PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury

(2019) Keisuke Takahata et al.   BRAIN

The individual course of neuropsychiatric symptoms in people with Alzheimer's and Lewy body dementia: 12-year longitudinal cohort study

(2019) Audun Osland Vik-Mo et al.   BRITISH JOURNAL OF PSYCHIATRY

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

(2019) Byron Creese et al.   INTERNATIONAL PSYCHOGERIATRICS

Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas

(2019) Lindsey Isla Sinclair et al.   Alzheimers Research & Therapy

Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits

(2019) Sophie E. Legge et al.   JAMA Psychiatry

Escitalopram for agitation in Alzheimer's disease (S-CitAD): Methods and design of an investigator-initiated, randomized, controlled, multicenter clinical trial

(2019) Stephan Ehrhardt et al.   Alzheimers & Dementia

Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia

(2019) Jennifer A. Watt et al.   ANNALS OF INTERNAL MEDICINE

Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease

(2019) Byron Creese et al.   Translational Psychiatry

Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease

(2019) Natalie Ellis et al.   BIOLOGICAL PSYCHIATRY

Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research

(2019) Corinne E. Fischer et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study

(2019) Naira Goukasian et al.   BMJ Open

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

(2018) Rebecca G. Smith et al.   Alzheimers & Dementia

Genome-wide analysis of adolescent psychotic-like experiences shows genetic overlap with psychiatric disorders

(2018) Oliver Pain et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer’s Disease

(2018) Josh M. Krivinko et al.   AMERICAN JOURNAL OF PSYCHIATRY

Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease

(2018) Winnie Qian et al.   Current Alzheimer Research

The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer’s disease

(2018) Byron Creese et al.   Expert Review of Neurotherapeutics

Associations between ZnT3, tau pathology, agitation, and delusions in dementia

(2018) David R. Whitfield et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Course of neuropsychiatric symptoms in dementia: 5-year longitudinal study

(2018) Audun Osland Vik-Mo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Dementia clinical trial implications of mild behavioral impairment

(2018) Moyra E. Mortby et al.   INTERNATIONAL PSYCHOGERIATRICS

Assessing mild behavioral impairment with the mild behavioral impairment checklist in people with subjective cognitive decline

(2018) Sabela C. Mallo et al.   INTERNATIONAL PSYCHOGERIATRICS

Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group

(2018) Fernando E. Taragano et al.   JOURNAL OF ALZHEIMERS DISEASE

Sequential drug treatment algorithm for agitation and aggression in Alzheimer’s and mixed dementia

(2018) Simon JC Davies et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study

(2018) Clive Ballard et al.   LANCET NEUROLOGY

Risk of dementia associated with psychotic disorders in later life: the health in men study (HIMS)

(2018) Osvaldo P. Almeida et al.   PSYCHOLOGICAL MEDICINE

The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer’s disease

(2018) Byron Creese et al.   Expert Review of Neurotherapeutics

Hyperphosphorylated Tau is Elevated in Alzheimer's Disease with Psychosis

(2018) Patrick S. Murray et al.   JOURNAL OF ALZHEIMERS DISEASE

Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment

(2018) Sabela C. Mallo et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer’s Disease

(2018) Alexander J. Ehrenberg et al.   JOURNAL OF ALZHEIMERS DISEASE

Advanced cerebral amyloid angiopathy and small vessel disease are associated with psychosis in Alzheimer’s disease

(2018) Audun Osland Vik-Mo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Association of anxiety with subcortical amyloidosis in cognitively normal older adults

(2018) Bernard J. Hanseeuw et al.   MOLECULAR PSYCHIATRY

Gray Matter Changes Associated With the Development of Delusions in Alzheimer Disease

(2018) Winnie Qian et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Association of Alzheimer's genetic loci with mild behavioral impairment

(2018) Shea J. Andrews et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Right hippocampus atrophy is independently associated with Alzheimer's disease with psychosis

(2018) Kangyoon Lee et al.   Psychogeriatrics

Diagnosis and Management of Neuropsychiatric Symptoms in Alzheimer’s Disease

(2018) David Wolinsky et al.   Current Psychiatry Reports

Reduced parahippocampal volume and psychosis symptoms in Alzheimer's disease

(2017) Emma McLachlan et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms

(2017) Eunsoo Won et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain atrophy is a frequent finding in elderly patients with first episode psychosis

(2017) Ulla-Marja Louhija et al.   INTERNATIONAL PSYCHOGERIATRICS

Frequency and subgroups of neuropsychiatric symptoms in mild cognitive impairment and different stages of dementia in Alzheimer's disease

(2017) N. Siafarikas et al.   INTERNATIONAL PSYCHOGERIATRICS

Psychosis and dementia: risk factor, prodrome, or cause?

(2017) Corinne E. Fischer et al.   INTERNATIONAL PSYCHOGERIATRICS

The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations

(2017) Zahinoor Ismail et al.   JOURNAL OF ALZHEIMERS DISEASE

Genetic risk for schizophrenia and psychosis in Alzheimer disease

(2017) M A A DeMichele-Sweet et al.   MOLECULAR PSYCHIATRY

Clinical and neurocognitive aspects of hallucinations in Alzheimer’s disease

(2017) Mohamad El Haj et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Transdiagnostic Extension of Delusions: Schizophrenia and Beyond

(2017) Paul Bebbington et al.   SCHIZOPHRENIA BULLETIN

Prevalence of Depression in Patients With Mild Cognitive Impairment

(2017) Zahinoor Ismail et al.   JAMA Psychiatry

A Systematic Review of Neuropsychiatric Symptoms in Mild Cognitive Impairment

(2017) Roberto Monastero et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment

(2016) Zahinoor Ismail et al.   Alzheimers & Dementia

Genetics of psychosis of Alzheimer disease

(2016) Chintan Shah et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients

(2016) Robert Howard et al.   BRITISH JOURNAL OF PSYCHIATRY

The Role of Cerebrovascular Disease on Cognitive and Functional Status and Psychosis in Severe Alzheimer’s Disease

(2016) Julia Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

High Frequency of GBA Gene Mutations in Dementia With Lewy Bodies Among Ashkenazi Jews

(2016) Tamara Shiner et al.   JAMA Neurology

Antipsychotic use in dementia: a systematic review of benefits and risks from meta-analyses

(2016) Rajesh R. Tampi et al.   Therapeutic Advances in Chronic Disease

Longitudinal Relationships Between Alzheimer Disease Progression and Psychosis, Depressed Mood, and Agitation/Aggression

(2015) Laura B. Zahodne et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions

(2015) Corinne E. Fischer et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Impact of Current Antipsychotic Medications on Comparative Mortality and Adverse Events in People With Parkinson Disease Psychosis

(2015) Clive Ballard et al.   Journal of the American Medical Directors Association

Neuropsychiatric symptoms, APOE  4, and the risk of incident dementia: A population-based study

(2015) A. Pink et al.   NEUROLOGY

Antipsychotics, Other Psychotropics, and the Risk of Death in Patients With Dementia

(2015) Donovan T. Maust et al.   JAMA Psychiatry

Neuropsychiatric symptoms in patients with Alzheimer’s disease with a vascular component

(2014) Mariola Bidzan et al.   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Agitation in cognitive disorders: International Psychogeriatric Association provisional consensus clinical and research definition

(2014) Jeffrey Cummings et al.   INTERNATIONAL PSYCHOGERIATRICS

Effect of Citalopram on Agitation in Alzheimer Disease

(2014) Anton P. Porsteinsson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Management of Neuropsychiatric Symptoms of Dementia in Clinical Settings: Recommendations from a Multidisciplinary Expert Panel

(2014) Helen C. Kales et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment

(2014) David R. Whitfield et al.   NEUROBIOLOGY OF AGING

Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities

(2014) Jeremy Koppel et al.   NEUROBIOLOGY OF AGING

On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis

(2014) Uli Hacksell et al.   NEUROCHEMICAL RESEARCH

Measuring missing heritability: Inferring the contribution of common variants

(2014) David Golan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

(2013) Yonas E. Geda et al.   Alzheimers & Dementia

Cognitive Decline and Dementia Risk in Older Adults With Psychotic Symptoms: A Prospective Cohort Study

(2013) Sebastian Köhler et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Neuropsychiatric Symptoms as Risk Factors for Progression From CIND to Dementia: The Cache County Study

(2013) M.E. Peters et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

The Association of Neuropsychiatric Symptoms in MCI with Incident Dementia and Alzheimer Disease

(2013) Paul B. Rosenberg et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

A Comparison of the E-BEHAVE-AD, NBRS, and NPI in Quantifying Clinical Improvement in the Treatment of Agitation and Psychosis Associated With Dementia

(2013) Zahinoor Ismail et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Regional Cortical Thinning Predicts Worsening Apathy and Hallucinations Across the Alzheimer Disease Spectrum

(2013) Nancy J. Donovan et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Neurobiology of Delusions, Memory, and Insight in Alzheimer Disease

(2013) David L. Sultzer et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Elevated CSF Tau is Associated With Psychosis in Alzheimer’s Disease

(2013) Jeremy Koppel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Psychosis in Alzheimer’s Disease

(2013) Patrick S. Murray et al.   BIOLOGICAL PSYCHIATRY

Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders

(2013) Shigeto Nagao et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Non-pharmacological treatment reducing not only behavioral symptoms, but also psychotic symptoms of older adults with dementia: A prospective cohort study in Taiwan

(2013) Rue-Chuan Chen et al.   Geriatrics & Gerontology International

Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network

(2013) Marcio L. F. Balthazar et al.   HUMAN BRAIN MAPPING

Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study

(2013) Martin Steinberg et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Content of delusional thoughts in Alzheimer's disease and assessment of content-specific brain dysfunctions with BEHAVE-AD-FW and SPECT

(2013) Masahiro Nakatsuka et al.   INTERNATIONAL PSYCHOGERIATRICS

Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial

(2013) Jeffrey Cummings et al.   LANCET

Delusions Increase Functional Impairment in Alzheimer’s Disease

(2012) Corinne E. Fischer et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Nonpharmacologic Management of Behavioral Symptoms in Dementia

(2012) Laura N. Gitlin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis

(2012) Patrick S. Murray et al.   NEUROBIOLOGY OF AGING

Neuroimaging of delusions in Alzheimer's disease

(2012) Zahinoor Ismail et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Neuropsychiatric symptoms in Alzheimer’s disease

(2011) Constantine G. Lyketsos et al.   Alzheimers & Dementia

Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease

(2011) D. Whitehead et al.   INTERNATIONAL PSYCHOGERIATRICS

Efficacy and Comparative Effectiveness of Atypical Antipsychotic Medications for Off-Label Uses in Adults

(2011) Alicia Ruelaz Maher et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neurobiology of Delusions in Alzheimer’s Disease

(2011) Zahinoor Ismail et al.   Current Psychiatry Reports

The Measurement of Psychosis in Dementia

(2010) Jiska Cohen-Mansfield et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Atypical antipsychotics for the treatment of behavioral and psychological symptoms in dementia, with a particular focus on longer term outcomes and mortality

(2010) Clive Ballard et al.   Expert Opinion On Drug Safety

Acute and transient psychosis in old age and the subsequent risk of dementia: A nationwide register-based study

(2009) Alex Kørner et al.   Geriatrics & Gerontology International

Management of agitation and aggression associated with Alzheimer disease

(2009) Clive G. Ballard et al.   Nature Reviews Neurology

Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease

(2009) S. Reeves et al.   NEUROLOGY

Regional distribution and behavioral correlates of 5-HT2A receptors in Alzheimer's disease with [18F]deuteroaltanserin and PET

(2009) Lekshmi Santhosh et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Late and very-late first-contact schizophrenia and the risk of dementia-a nationwide register based study

(2008) Alex Kørner et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study

(2007) Martin Steinberg et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY