Article
Clinical Neurology
Joseph Pleen, Ryan Townley
Summary: The review of clinical trials targeting Alzheimer's disease from 2019 to 2021 showed that the role of biomarkers is expanding, but there are still many challenges in targeting disease modification of AD. New clinical and observational trials are focusing on prevention and diverse biological processes that influence AD pathology to halt or slow clinical progression of the disease.
JOURNAL OF NEUROLOGY
(2022)
Article
Psychiatry
Johanna C. Badcock, Rachel Brand, Neil Thomas, Mark Hayward, Georgie Paulik
Summary: This study found that 72.1% of clients reported experiencing multimodal hallucinations in the past month. Both multimodal and unimodal hallucination groups showed improvement in distress and frequency of hallucinations post-treatment, with no significant group differences in treatment outcomes. Within the subgroup reporting ongoing effects of traumatic events, clients with multimodal hallucinations had significantly higher posttraumatic stress symptoms.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Wei Lin Toh, Caitlin Yolland, Caroline Gurvich, James Barnes, Susan L. Rossell
Summary: This study conducted a systematic review on non-visual hallucinations in Parkinson's disease, exploring their prevalence, phenomenology, and clinical-cognitive correlates. The findings revealed that non-visual hallucinations are prevalent in Parkinson's disease and have clinical significance, highlighting the need for further research and clinical attention.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Badri N. Vardarajan, Dolly Reyes-Dumeyer, Angel L. Piriz, Rafael A. Lantigua, Martin Medrano, Diones Rivera, Ivonne Z. Jimenez-Velazquez, Eden Martin, Margaret A. Pericak-Vance, William Bush, Lindsay Farrer, Jonathan L. Haines, Li-San Wang, Yuk Yee Leung, Gerard Schellenberg, Walter Kukull, Philip De Jager, David A. Bennett, Julie A. Schneider, Richard Mayeux
Summary: This study found that pathogenic GRN mutations are common in FTLD and AD, often with TDP-43 pathology. Pathogenic GRN carriers have significantly higher PHFtau tangle density associated with AD. The rs5848 mutation is associated with increased frequency of hippocampal sclerosis and TDP-43 deposits in AD patients.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Stefania Pezzoli, Riccardo Manca, Annachiara Cagnin, Annalena Venneri
Summary: In Alzheimer's disease (AD), visual hallucinations (VH) are associated with more severe cognitive and brain structural changes. Compared to patients without VH (NVH), VH patients show more severe visuoconstructive and attentional deficits. VH patients have gray matter atrophy and hypometabolism in the occipital and temporal areas of the brain. These findings contribute to our understanding of the emergence and development of VH in AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychiatry
Mohamad El Haj, Frank Laroi, Karim Gallouj
Summary: The study found that hallucinatory experiences increased in patients with AD living in retirement homes during the lockdown, possibly due to decreased social and physical activities, as well as physical separation from family members. While necessary to combat the spread of Covid-19, the restrictive measures appeared to exacerbate hallucinations in these patients.
PSYCHIATRIC QUARTERLY
(2021)
Article
Clinical Neurology
Elizabeth K. Rhodus, P. Aisen, J. D. Grill, D. M. Rentz, R. C. Petersen, R. A. Sperling, S. P. Salloway, D. Pierce, R. Raman
Summary: This study examines the adaptations to clinical trial research due to COVID-19 and develops a theoretical framework of emergent strategies in a national network of Alzheimer's disease clinical trial sites. The findings highlight the importance of safety, scientific preservation, accommodations, and evaluation of changes during the pandemic. Communication and maintaining integrity are crucial throughout these processes.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Angeliki Zarkali, Peter McColgan, Louise Ann Leyland, Andrew John Lees, Rimona Sharon Weil
Summary: Patients with Parkinson's disease hallucinations show significant white matter changes, particularly in posterior connections and thalamic nuclei. Cortical thickness changes are less extensive. Thalamic nucleus of the right medial mediodorsal showed both connectivity and volume loss in PD hallucinations.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Clinical Neurology
Francisco Lopera, Nilton Custodio, Mariana Rico-Restrepo, Ricardo F. Allegri, Jose Domingo Barrientos, Estuardo Garcia Batres, Ismael L. Calandri, Cristian Calero Moscoso, Paulo Caramelli, Juan Carlos Duran Quiroz, Angela Marie Jansen, Alberto Jose Mimenza Alvarado, Ricardo Nitrini, Jose F. Parodi, Claudia Ramos, Andrea Slachevsky, Sonia Maria Dozzi Brucki
Summary: Alzheimer's disease is a significant burden in Latin America and the Caribbean due to limited access to diagnosis and treatment, fragmented healthcare systems, and various barriers such as genetic heterogeneity and social determinants of health. To address these issues, a group of experts convened a virtual meeting to discuss best practices and recommendations, including additional training for healthcare workers, adapted cognitive tests, expanded healthcare insurance coverage, and gene variant detection strategies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Ioanna Pachi, Vassilis Papadopoulos, Christos Koros, Athina Maria Simitsi, Anastasia Bougea, Maria Bozi, Nikos Papagiannakis, Rigas Filippos, Rigas Filippos Soldatos, Dimitra Kolovou, George Pantes, Nikolaos Scarmeas, Georgios Paraskevas, Konstantinos Voumvourakis, Sokratis G. Papageorgiou, Konstantinos Kollias, Nikos Stefanis, Leonidas Stefanis
Summary: Psychotic symptoms, mainly of minor nature, are highly common in the early stages of Parkinson's disease (PD). These symptoms are associated with cumulative non-motor symptoms, REM sleep behavior disorder (RBD), and depressive features.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Janne Marieke Herden, Peter Hermann, Isabel Schmidt, Kathrin Dittmar, Sezgi Canaslan, Luise Weglage, Sabine Nuhn, Corinna Volpers, Astrid Schlung, Stefan Goebel, Fabian Kueck, Anna Villar-Pique, Christian Schmidt, Dirk Wedekind, Inga Zerr
Summary: This study investigates the clinical characteristics and biomarkers associated with rapidly progressive Alzheimer's disease (rpAD). The findings suggest that rpAD is characterized by distinct cognitive profiles, earlier occurrence of non-cognitive symptoms, extrapyramidal motoric disturbance, and lower CSF amyloid-beta 1-42 concentrations. These findings provide important insights for the diagnosis and prognosis of rpAD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Calogero Edoardo Cicero, Antonina Luca, Giovanni Mostile, Giulia Donzuso, Loretta Giuliano, Mario Zappia, Alessandra Nicoletti
Summary: In Parkinson's disease, REM sleep behavior disorder (RBD) can either precede motor symptoms or develop during the course of the disease. Patients with RBD have a higher burden of cognitive impairment and hallucinations. This study analyzed the clinical characteristics of Parkinson's disease patients based on the timeline of RBD onset.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Shuntaro Natsume, Hajime Baba, Hitoshi Maeshima, Takao Saida, Naoto Yoshinari, Kentaro Shimizu, Toshihito Suzuki
Summary: Depression is a risk factor for Alzheimer's disease, and changes in A13 protein metabolism may contribute to the transition from depression to AD. This study found that elderly patients with depression had decreased A1342 levels at admission, but these levels recovered to healthy levels 1 year after remission.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Geriatrics & Gerontology
Ta-Wei Guu, Dag Aarsland, Dominic Ffytche
Summary: Inadequate environmental light may be a risk factor for BPSD and sundowning syndrome in dementia patients. It affects activity rhythm and worsens behavioral symptoms. Increasing light exposure and adjusting the environmental setting should be considered in the treatment of dementia patients with BPSD.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychiatry
Thomas Fovet, Baptiste Pignon, Marielle Wathelet, Imane Benradia, Jean-Luc Roelandt, Renaud Jardri, Pierre Thomas, Fabien D'Hondt, Ali Amad
Summary: This study investigates the prevalence of psychotic symptoms and psychotic disorders in incarcerated men and compares it with the general population. The study finds that psychotic disorders are more prevalent in men entering jail, while psychotic symptoms are less prevalent. This difference may be due to exposure to vulnerability factors rather than the act of entering jail itself.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Pierre Gerain, Emilie Wawrziczny, Pascal Antoine
Summary: This study utilized psychological network analysis to explore the relationships between caregivers and partners with dementia. The results revealed a complex network of interacting variables, with dyadic adjustment playing a central role and distress being associated with other variables through various direct and indirect pathways.
AGING & MENTAL HEALTH
(2023)
Article
Neurosciences
P. A. Geoffroy, C. M. Schroder, P. Bourgin, J. Maruani, M. Lejoyeux, M. -P. d'Ortho, C. Couffignal, P. Philip, I. Arnulf, S. Royant-Parola, D. Leger, B. Gohier, F. Gagnadoux, A. Amad, I. Poirot, R. Gaillard, F. Limosin, R. Delorme, R. Jardri, P. Fossati, C. Dubertret, B. Rolland, B. Etain, F. Vorspan, B. Aouizerate, P. Courtet, J. L. Castroman, E. Haffen, D. Drapier, A. Dereux, R. Schwan, A. Luquiens, B. Abril, M. Auriacombe, A. Benyamina, R. Lopez, M. Grall-Bronnec, D. Bennabi, J. Frija-Masson, J. -A. Micoulaud Franchii, T. Schwitzer, J. -B. Maranci, U. K. Huck
Summary: To better identify biomarkers of sleep and biological rhythms and validate more homogeneous subgroups of patients with depressive disorders, a French national cohort was built. A Delphi process was conducted to achieve consensus and establish a validated data collection set of questionnaires to assess psychiatry, addiction, sleep, and chronobiology dimensions of depressive disorders.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2023)
Article
Psychology, Clinical
Charlotte Manceau, Emilie Constant, Elodie Brugalle, Emilie Wawrziczny, Celine Sokolowski, Berengere Flinois, Guillaume Baille, Luc Defebvre, Kathy Dujardin, Pascal Antoine
Summary: This qualitative study aims to understand the experience and functioning of couples during the honeymoon period of Parkinson's disease. The results highlight different dynamics between couples, with some adjusting flexibly and positively while others oscillate between rigid hyperprotection and control/avoidance.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Psychiatry
Mohamad El Haj, Ahmed A. A. Moustafa
Summary: The objective of this study was to investigate decision making in patients with Korsakoff syndrome (KS). The findings revealed that patients with KS tend to prefer immediate over future rewards compared to control participants. Additionally, temporal discounting was found to be correlated with inhibition in both populations. These results suggest that patients with KS may have difficulties suppressing the temptation of smaller, immediate rewards.
COGNITIVE NEUROPSYCHIATRY
(2023)
Article
Neurosciences
Layla Lavalle, Jerome Brunelin, Renaud Jardri, Frederic Haesebaert, Marine Mondino
Summary: Distinguishing imagination and thoughts from perceived information in reality-monitoring is important, but the common brain substrates between reality monitoring and self-monitoring have received little attention. Using meta-analyses of functional magnetic resonance imaging studies, we found that the lobule VI of the cerebellum consistently engages in both reality- and self-monitoring. This offers new insights into the common brain regions underlying these two cognitive processes and suggests that the neural signature of self persists in memories.
HUMAN BRAIN MAPPING
(2023)
Article
Psychiatry
Jean-Pierre Jacus, Virginie Voltzenlogel, Audric-Joel Farrie, Pascal Antoine, Christine-Vanessa Cuervo-Lombard
Summary: Impaired awareness in patients with Alzheimer's Disease (AD) increases dependence and burden on caregivers, but clinical evaluation of this symptomatology remains inadequate. The three main assessment methods, patient-caregiver discrepancy, clinician rating, and performance discrepancy methods, have limited impact due to lack of validated evaluation tools, leading to contrasting results. Recent studies show positive correlations between impaired awareness and apathy and AD severity, and negative relationships with depressive symptoms. Therefore, impaired awareness is mainly influenced by patient's depression and apathy. The shared aspects of apathy and impaired awareness are discussed from neuroanatomical, clinical, and conceptual perspectives, along with the relevance and limitations of quantitative and qualitative assessment methods, particularly phenomenological.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2023)
Article
Neurosciences
Mohamad El Haj, Claire Boutoleau-Bretonniere, Lina Guerrero Sastoque, Quentin Lenoble, Ahmed A. A. Moustafa, Guillaume Chapelet, Elisa Sarda, Andre Ndobo
Summary: This study compared the eye movement differences between men and women during autobiographical memory retrieval. The findings showed that women had shorter fixations, longer duration and amplitude of saccades, and higher autobiographical specificity compared to men. However, these gender differences in eye movement disappeared after controlling for autobiographical specificity. Female participants generated a larger scan with shorter fixation and higher saccade amplitude during autobiographical retrieval, whereas male participants increased their fixation duration and showed poorer gaze scan. The large saccades in women during autobiographical retrieval may contribute to better autobiographical memory functioning and the retrieval of more autobiographical details compared to men.
Editorial Material
Psychology, Experimental
Mohamad El Haj
Summary: In order to have a comprehensive understanding of autobiographical memory, WIREs Cognitive Science is releasing a special issue that gathers contributions from various perspectives in the field. The article introduces the philosophy of the collaborative project and the knowledge gained from the included articles, as well as insights into future research directions. It highlights the interdisciplinary nature of autobiographical memory research and the first-time gathering of different theoretical approaches in this special issue.
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
(2023)
Article
Neurosciences
Melodie Derome, Petya Kozuharova, Andreea O. Diaconescu, Sophie Deneve, Renaud Jardri, Paul Allen
Summary: The study investigates the presence of central inference mechanism in individuals with high schizotypy traits and its neurobiological basis associated with sensory amplification. The findings reveal changes in central inference parameters, altered cortical excitatory neurotransmission, and altered resting state functional connectivity related to sensory amplification in individuals with high schizotypy traits.
Article
Behavioral Sciences
Daniel Collerton, James Barnes, Nico J. Diederich, Rob Dudley, Dominic Ffytche, Karl Friston, Christopher G. Goetz, Jennifer G. Goldman, Renaud Jardri, Jaime Kulisevsky, Simon J. G. Lewis, Shigetoshi Naral, Claire O'Callaghan, Marco Onofrj, Javier Pagonabarraga, Thomas Parr, James M. Shine, Glenn Stebbins, John-Paul Taylor, Ichiro Tsuda, Rimona S. Weil
Summary: Despite years of research, it remains uncertain why people sometimes perceive things that aren't there. Eight models of complex visual hallucinations have been proposed since 2000, each based on different understandings of brain organization. To address this variability, researchers established an integrated Visual Hallucination Framework that aligns with current theories of veridical and hallucinatory vision, enabling a systematic investigation of the relationship between hallucination phenomenology and cognitive structures. The episodic nature of hallucinations suggests a complex relationship between state and trait markers, highlighting new avenues for research and potential approaches to treating distressing hallucinations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Geriatrics & Gerontology
P. Gerain, E. Wawrziczny, P. Antoine
Summary: This scoping review aims to summarize the use of intensive longitudinal methods (ILMs) in informal dementia caregivers. The results show that ILMs have the potential to contribute to understanding the complexity of daily life and the changing resources and challenges of dementia caregivers. However, further research is needed on emotion regulation, temporal lags, and the use of ILMs in interventional designs.
Article
Medicine, General & Internal
Mohamad El Haj, Claire Boutoleau-Bretonniere, Guillaume Chapelet
Summary: In this study, the researchers measured the pupil dilation of both older and younger adults while they performed tasks requiring cognitive inhibition. The results showed that both age groups had fewer accurate responses in the interference condition compared to the color-naming and word-reading conditions. Additionally, larger pupil dilation was observed in the interference condition for both older and younger adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Mohamad El Haj, Ahmed A. Moustafa, Philippe Allain
Summary: This study aimed to investigate whether processing attributes of destinations would improve destination memory in patients with traumatic brain injury (TBI). The results showed that destination memory was better after introspection compared to control condition in healthy participants. However, there were no significant differences between the two conditions in patients with TBI. Nevertheless, more than half of the patients with TBI demonstrated better destination memory after introspection. Further research is needed to understand how introspection may influence memory in social interactions in patients with TBI.
Article
Linguistics
Mohamad El Haj, Dimitrios Kapogiannis, Claire Boutoleau-Bretonniere
Summary: This study assessed linguistic processing in patients with behavioral variant frontotemporal dementia (bvFTD) using pupillometry. The results showed that patients with bvFTD had smaller pupil size during verbal fluency tasks and counting compared to control participants. However, larger pupil size was observed during verbal fluency tasks compared to counting in both groups. Moreover, patients with bvFTD performed poorer in verbal fluency tasks compared to control participants.
JOURNAL OF NEUROLINGUISTICS
(2024)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)
