Article
Biochemistry & Molecular Biology
Nicole E. E. Eassa, Stephanie M. M. Perez, Angela M. M. Boley, Hannah B. B. Elam, Dishary Sharmin, James M. M. Cook, Daniel J. J. Lodge
Summary: Of the 35 million people suffering from Alzheimer's Disease (AD) worldwide, up to half have comorbid psychosis. Antipsychotics are not suitable for elderly patients due to increased risk of premature death. The hippocampus is hyperactive in patients with psychosis and AD, and targeting a5-GABAA receptors can reverse aberrant dopamine system function. This study provides evidence for developing drugs for AD patients with comorbid psychosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Stephanie M. Perez, Angela M. Boley, Alexandra M. McCoy, Daniel J. Lodge
Summary: Antipsychotics increase the risk of death in elderly patients with Alzheimer's disease (AD). There is a need for new therapies to treat comorbid psychosis in AD. This study used a ferrous amyloid buthionine (FAB) rodent model to investigate the relationship between hippocampal activity and dopamine-dependent psychosis in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Elizabeth B. Wright, Erik G. Larsen, Cecilia M. Coloma-Roessle, Hannah R. Hart, Martha R. C. Bhattacharya
Summary: Loss of TMEM184B affects synaptic gene expression and anxiety-related behaviors, suggesting a potential link to neurodevelopmental disorders.
Article
Neurosciences
David C. Zhu, Chih-Ying Gwo, An-Wen Deng, Norman Scheel, Mari A. Dowling, Rong Zhang
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that leads to dementia among older adults. This study aimed to develop methods to characterize the shape of the hippocampus and explore its potential as an imaging marker for monitoring clinical AD progression. The researchers used a 3D Zernike transformation to analyze hippocampus shapes in older subjects with brain scans from the Alzheimer's Disease Neuroimaging Initiative data set. The results showed a correlation between hippocampal volume changes and Zernike shape metrics, suggesting that shape features could serve as a novel imaging marker for monitoring AD progression.
HUMAN BRAIN MAPPING
(2023)
Article
Biochemical Research Methods
Na Ying, Hanqi Luo, Baixia Li, Kaiyan Gong, Fei Liang, Hongchang Gao, Tao Huang, Hong Zheng
Summary: Exercise, including high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), can improve behavioral and cognitive impairments in Alzheimer's disease (AD) mice. Metabolomics analysis reveals significant changes in energy metabolism, neurotransmitter metabolism, and membrane metabolism in multiple brain regions after both types of exercises. HIIT also alters astrocyte-neuron metabolism in the hippocampus and hypothalamus of AD mice. These findings suggest that exercise can modulate brain metabolism in a region- and exercise-specific manner, potentially providing a novel approach for the prevention and treatment of AD.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Heidy Jimenez, Joseph Carrion, Leslie Adrien, Adam Wolin, John Eun, Ezra Cinamon, Eric H. Chang, Peter Davies, An Vo, Jeremy Koppel
Summary: Psychosis occurring in Alzheimer's disease is associated with increased caregiver burden and faster cognitive decline. Previous studies have used agents known to induce psychosis to model psychotic conditions and evaluate their effects on behavior in rodents. This report investigates the impact of antimuscarinic and dopaminergic treatments on locomotion and sensorimotor gating using human tau models. The results suggest that antimuscarinic treatment increases locomotion and tau pathology, while dopaminergic treatment reduces locomotion without affecting sensorimotor gating. Further studies are needed to explore the potential of muscarinic agonists in treating tauopathies like Alzheimer's disease.
Article
Neurosciences
Hongtao Shen, Tianzhen Zhang, Yao Ji, Yu Zhang, Yongxiang Wang, Yuling Jiang, Xiongjin Chen, Qiuhao Liang, Kefeng Wu, Yunfeng Li, Xingyu Lu, Lili Cui, Bin Zhao, Yan Wang
Summary: GRK5 plays a vital role in maintaining normal cognitive function and its loss can lead to microglial function deficits and molecular pathology related to Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Shan-shan Zhang, Lin Zhu, Yan Peng, Lei Zhang, Feng-lei Chao, Lin Jiang, Qian Xiao, Xin Liang, Jing Tang, Hao Yang, Qi He, Yi-jing Guo, Chun-ni Zhou, Yong Tang
Summary: The role of physical exercise in the prevention and treatment of Alzheimer's disease (AD) has been investigated in a study on mice. Voluntary running improved cognitive function and promoted brain glucose metabolism and microglial metabolic activity. Running exercise also enhanced the morphology and proliferation of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Plant Sciences
Fatemeh Panahzadeh, Rahim Mirnasuri, Masoud Rahmati
Summary: This study aimed to investigate the effect of endurance training and clove oil on spatial memory, apoptosis, mitochondrial homeostasis, and cognitive function in Alzheimer's rats. The results suggest that swimming training and clove oil supplementation may be effective interventions to maintain oxidative balance and improve mitochondrial homeostasis in Alzheimer's disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Neurosciences
Giulia Torromino, Adriana Maggi, Elvira De Leonibus
Summary: Women are more prone than men to develop age-related dementia, such as Alzheimer's disease, due to sex differences in the neurobiology of memory leading to lower usage of the hippocampus in females. The decreased utilization of the hippocampus makes women more vulnerable to the effects of ageing. It is suggested that exercise, cognitive training, and orienteering could be effective in preventing and counteracting Alzheimer's disease.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sonia C. Correia, Marco G. Alves, Pedro F. Oliveira, Gemma Casadesus, Joseph LaManna, George Perry, Paula I. Moreira
Summary: This study demonstrates that hypoxic preconditioning can prevent the sAD-like phenotype, partly by targeting mitochondria as a preventive strategy in the context of AD. Preconditioning with hypoxia enhances complex II-energized mitochondrial respiration in the hippocampus, improving mitochondrial function and mitochondrial DNA content. These findings provide a novel direction for hypoxic preconditioning as a preventive strategy for AD.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Geriatrics & Gerontology
Shuntai Chen, Dian Zhang, Honggang Zheng, Tianyu Cao, Kun Xia, Mingwan Su, Qinggang Meng
Summary: The thickness of the retina is found to degenerate in the pathological process of Alzheimer's disease (AD), while hippocampal atrophy is a typical feature of AD. The association between retinal thickness and hippocampal atrophy in AD is unclear. This study aims to quantify the correlation between these two parameters and explore the potential of using retinal thickness as a biomarker for early AD detection.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Neurosciences
Hannah M. O. Reid, Nathan Chen-Mack, Taylor Snowden, Brian R. Christie
Summary: This systematic review focused on the relationship between Alzheimer's disease and hippocampal interneurons, highlighting the early impact on PV interneurons and later effects on NPY and CCK interneurons. Future studies should aim to clarify the role of PV interneurons in Alzheimer's disease and conduct further investigations on NPY and CCK interneurons.
BRAIN CONNECTIVITY
(2021)
Article
Medicine, General & Internal
Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir El Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay
Summary: The study found that high soluble Aβ42 levels are associated with normal cognition and hippocampal volume despite increasing brain amyloidosis, suggesting that preserving high soluble Aβ42 levels could be important for maintaining cognitive function and hippocampal health.
Article
Neurosciences
Daisuke Ibi, Kazuki Hirashima, Yuya Kojima, Kahori Sumiya, Sari Kondo, Mirai Yamamoto, Toshihiro Ando, Masayuki Hiramatsu
Summary: Long-term intake of betaine can prevent cognitive impairment and aberrant expression of genes related to antioxidant activity in the hippocampus of a genetic AD model, suggesting that betaine may be a potential agent for preventing the progression of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Editorial Material
Neurosciences
Giok Kim, Eunsoo Moon, Je Min Park, Byung Dae Lee, Young Min Lee, Hee Jeong Jeong, Soo Yeon Kim, Kangyoon Lee, Hwagyu Suh
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2020)