Article
Clinical Neurology
Behnam Iravani, Elaheh Abdollahi, Fatemeh Eslamdoust-Siahestalkhi, Robabeh Soleimani
Summary: This study assessed the relationship between neuropsychiatric symptoms in patients with Alzheimer's disease and caregiver burden. The results showed a significant correlation between NPS and CB, with apathy being the most common symptom in AD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Maria Grazia Maggio, Gianluca La Rosa, Patrizia Calatozzo, Adriana Andaloro, Marilena Foti Cuzzola, Antonino Cannavo, David Militi, Alfredo Manuli, Valentina Oddo, Giovanni Pioggia, Rocco Salvatore Calabro
Summary: The COVID-19 pandemic has led to a public health emergency, causing isolation and social distancing which significantly impacted caregivers of patients with Alzheimer's disease. Caregivers perceived high levels of stress and burden, mainly due to physical difficulties and time-dependence burden. They reported low quality of life and mostly used dysfunctional coping strategies like avoidance, which did not affect their stress levels significantly. Innovative tools may be valuable in supporting caregivers during difficult periods like the COVID-19 pandemic.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Jennifer Young Tu, Grace Jin, Jen-Hau Chen, Yen-Ching Chen
Summary: The study aims to recommend valid, reliable, and comprehensive self-report instruments for assessing caregiver burden. Through a systematic review, 40 high-quality articles were selected, and several self-report instruments were recommended based on their validity, reliability, and inclusiveness.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Boyoung Kim, Jennifer Ivy Kim, Hae Ri Na, Kang Sook Lee, Kyung-hee Chae, Sukil Kim
Summary: This study analyzed data of dementia patients in Seoul, South Korea to identify factors affecting caregiver burden based on the severity of dementia. Results showed that caregiver burden increased with the severity of the disease, highlighting the need for targeted support for caregivers at different stages of dementia.
Article
Geriatrics & Gerontology
Manuela Tondelli, Francesca Benuzzi, Daniela Ballotta, Maria Angela Molinari, Annalisa Chiari, Giovanna Zamboni
Summary: Recent studies on anosognosia in dementia have suggested the presence of implicit self-awareness that regulates responses, even in patients without explicit awareness. A preserved response of the posterior cingulate cortex to dementia-related stimuli may indicate preserved implicit self-awareness.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Oriol Turro-Garriga, Vanesa Vinas-Diez, Lluis Zacarias-Pons, Josep-Lluis Conde-Sala, Josep Garre-Olmo
Summary: This study reports evidence of the effect of sense of coherence (SOC) on burden reports in relatives of persons with dementia. The findings suggest that caregivers with higher SOC experience lower burden levels throughout the follow-up, whereas those with lower SOC report greater burden at each visit.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Manee Pinyopornpanish, Kanokporn Pinyopornpanish, Atiwat Soontornpun, Surat Tanprawate, Angkana Nadsasarn, Nahathai Wongpakaran, Tinakon Wongpakaran
Summary: This study found that caregiver burden is indirectly associated with patients' neuropsychiatric symptoms through the caregiver's depressive symptoms and perception of stress. Early detection and appropriate interventions can help in reducing and preventing caregiver burden.
Article
Neurosciences
Taylor Rigby, David K. Johnson, Angela Taylor, James E. Galvin
Summary: This cross-sectional study found no differences in caregiver characteristics or disease severity distribution between DLB, PDD, and AD. Instead, the caregiver's experience was dependent on caregiver and care recipient characteristics, as well as the most disturbing symptoms, with behavior, personality changes, and sleep having the greatest impact on psychosocial constructs.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Clinical Neurology
Jemma Hazan, Michelle Wing, Kathy Y. Liu, Suzanne Reeves, Robert Howard
Summary: This study evaluated the clinical utility of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease (AD) in patients with cognitive impairment. The meta-analysis showed that the use of CSF biomarkers led to changes in diagnosis, increased diagnostic confidence, and influenced patient management. Further research is needed to explore the clinical utility of blood-based biomarkers.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Hind A. Beydoun, May A. Beydoun, Osorio Meirelles, Lance D. Erickson, Alyssa A. Gamaldo, Jordan Weiss, Lenore J. Launer, Michele K. Evans, Alan B. Zonderman
Summary: This study found that among older adults, total and hospitalized infection may be associated with incidence of all-cause and Alzheimer's disease dementias, with variation by cardiovascular health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Aliza P. Wingo, Selina M. Vattathil, Jiaqi Liu, Wen Fan, David J. Cutler, Allan Levey, Julie A. Schneider, David A. Bennett, Thomas S. Wingo
Summary: This study found that LDL-C is associated with various neuropathological manifestations of AD independent of APOE, suggesting that LDL-C may be a modifiable risk factor for AD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
David B. Reuben, Tahmineh Romero, Leslie Chang Evertson, Lee A. Jennings
Summary: This study found that caregivers who felt overwhelmed at the beginning of a comprehensive dementia care program had more distress, worse depression scores, and higher dementia burden at baseline compared to caregivers who were not overwhelmed. These overwhelmed caregivers also had worse depressive symptoms, strain, and burden scores one year later. However, having an overwhelmed caregiver did not predict long-term nursing home placement or mortality among persons with dementia.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Psychiatry
James Chung-Wai Cheung, Bryan Pak-Hei So, Ken Hok Man Ho, Duo Wai-Chi Wong, Alan Hiu-Fung Lam, Daphne Sze Ki Cheung
Summary: Wrist accelerometry shows significant association with agitated behavior in elderly dementia patients, but its performance in identifying agitation episodes is unsatisfactory. Future studies should focus on unifying parameters and measurement periods, and using a sampling window to standardize the assessment protocol.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Christina S. Dintica, Amaia Calderon-Larranaga, Davide Liborio Vetrano, Weili Xu
Summary: This study examined the relationship between sensory impairment and dementia, and whether social network and leisure activity could moderate this association. The results showed that dual impairment in hearing and vision was associated with a higher risk of dementia. However, having a richer social network and engaging in stimulating activities could help mitigate this risk in older adults with dual impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Min Young Chun, Hyemin Jang, Soo-Jong Kim, Yu Hyun Park, Jihwan Yun, Samuel N. Lockhart, Michael Weiner, Charles De Carli, Seung Hwan Moon, Jae Yong Choi, Kyung Rok Nam, Byung-Hyun Byun, Sang-Moo Lim, Jun Pyo Kim, Yeong Sim Choe, Young Ju Kim, Duk L. Na, Hee Jin Kim, Sang Won Seo
Summary: Alzheimer's disease (AD) is characterized by amyloid-beta accumulation, tau aggregation, and neurodegeneration. Vascular burden has synergistic effects on cognitive decline with AD biomarkers. The distribution and longitudinal outcomes of AT(N) categories differ according to vascular burden, emphasizing the importance of incorporating a vascular biomarker into the AT(N) system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Marc A. Khoury, Mohamad-Ali Bahsoun, Ayad Fadhel, Shukrullah Shunbuli, Saanika Venkatesh, Abdollah Ghazvanchahi, Samir Mitha, Karissa Chan, Luis R. Fornazzari, Nathan W. Churchill, Zahinoor Ismail, David G. Munoz, Tom A. Schweizer, Alan R. Moody, Corinne E. Fischer, April Khademi
Summary: This study investigates the relationship between delusional severity and volume and texture biomarkers in cognitively impaired adults using FLAIR MRI. The results suggest that patients with more severe delusions have greater tissue degeneration in the NABM region (gray matter and white matter combined), which is significantly associated with CSF tau.
Article
Neurosciences
Andrew S. Dissanayake, Yu Bin Tan, Christopher R. Bowie, Meryl A. Butters, Alastair J. Flint, Damien Gallagher, Angela C. Golas, Nathan Herrmann, Zahinoor Ismail, James L. Kennedy, Sanjeev Kumar, Krista L. Lanctot, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji, Michael Tau, Anika Maraj, Nathan W. Churchill, Debby Tsuang, Tom A. Schweizer, David G. Munoz, Corinne E. Fischer
Summary: This study suggests that the gene APOE ε4 may be more strongly associated with neuropsychiatric symptom burden in females with Alzheimer's disease, especially in APOE ε4/4 females. This finding provides insights for further investigation into the underlying mechanisms of this association.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Mila Valcic, Marc A. Khoury, Julia Kim, Luis Fornazzari, Nathan W. Churchill, Zahinoor Ismail, Vincenzo De Luca, Debby Tsuang, Tom A. Schweizer, David G. Munoz, Corinne E. Fischer
Summary: This study found that sex and zygosity influence the effect of APOE4 on psychosis in neuropathologically confirmed AD patients, with the effect being limited to females with Lewy body pathology.
Article
Psychiatry
Corinne E. Fischer, Andrew Namasivayam, Lucas Crawford -Holland, Narek Hakobyan, Tom A. Schweizer, David G. Munoz, Bruce G. Pollock
PSYCHIATRIC CLINICS OF NORTH AMERICA
(2022)
Article
Neurosciences
Jimmy K. Y. Wong, Nathan W. Churchill, Simon J. Graham, Andrew J. Baker, Tom A. Schweizer
Summary: This study aims to investigate the roles of the default mode network (DMN) and executive control network (ECN) in prolonged recovery after mild traumatic brain injury (mTBI), as well as their relationships with indices of white matter microstructural injury. The results showed that patients with mTBI had increased functional connectivity of the DMN and ECN to brain regions implicated in salience and frontoparietal networks, as well as increased white matter diffusivity within the cerebrum and brainstem. These findings suggest that hyper-connectivity may represent a compensatory response in female mTBI patients with prolonged symptoms.
Editorial Material
Clinical Neurology
Jennifer Dawson, Sharon Johnston, Shawn Marshall, Tom A. Schweizer, Nick Reed, Hannes Devos, Julianne Schmidt, Alexander Lithopoulos, Roger Zemek
JOURNAL OF HEAD TRAUMA REHABILITATION
(2023)
Correction
Neurosciences
Mila Valcic, Marc A. A. Khoury, Julia Kim, Luis Fornazzari, Nathan W. W. Churchill, Zahinoor Ismail, Vincenzo De Luca, Debby Tsuang, Tom A. A. Schweizer, David G. G. Munoz, Corinne E. E. Fischer
Article
Neurosciences
Rachel Patterson, Heather G. Brooks, Mina Mirjalili, Neda M. Rashidi-Ranjbar, Reza R. Zomorrodi, Daniel Blumberger, Corinne Fischer, Alastair Flint, Ariel Graff-Guerrero, Nathan Herrmann, James Kennedy, Sanjeev L. Kumar, Krista Lanctot, Linda Mah, Benoit Mulsant, Bruce Pollock, Aristotle Voineskos, Wei Wang, Tarek N. Rajji
Summary: Theta-gamma coupling is an independent neurophysiological process that supports working memory in older adults at risk for dementia, and is not associated with other clinical, genetic, neurochemical, and structural variables.
COGNITIVE NEURODYNAMICS
(2023)
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Shijing Wang, Sidney H. Kennedy, Tim V. Salomons, Amanda K. Ceniti, Shane J. McInerney, Yvonne Bergmans, Diego A. Pizzagalli, Norman Farb, Gustavo Turecki, Tom A. Schweizer, Nathan Churchill, Mark Sinyor, Sakina J. Rizvi
Summary: This study aims to explore the relationship between suicide capability and pain in patients with Major Depressive Disorder (MDD) and identify the neural network associated with pain processing. The results reveal a positive correlation between suicide capability and pain endurance, and a negative correlation with pain threshold intensity. Additionally, suicide capability is associated with the functional connectivity strength of four brain regions in MDD patients, and this correlation is weaker in healthy controls. Pain threshold intensity serves as a mediator between suicide capability and connectivity strength.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Nathan W. Churchill, Simon J. Graham, Tom A. Schweizer
NEUROIMAGING CLINICS OF NORTH AMERICA
(2023)
Article
Clinical Neurology
Nathan W. W. Churchill, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Xiang Ji, Fuqiang Gao, Zhongmin Lin, Aravinthan Jegatheesan, Mario Masellis, Maged Goubran, Jennifer S. S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. E. Black, Bradley J. J. MacIntosh, Simon J. J. Graham, Tom A. A. Schweizer
Summary: This cross-sectional observational study aimed to determine if there are significant alterations in resting brain function among non-hospitalized individuals with PACS. The results showed that COVID-19 patients had lower functional connectivity in the brain, and the severity of symptoms was associated with altered functional connectivity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Behavioral Sciences
Nathan W. Churchill, Eugenie Roudaia, J. Jean Chen, Asaf Gilboa, Allison Sekuler, Xiang Ji, Fuqiang Gao, Zhongmin Lin, Mario Masellis, Maged Goubran, Jennifer S. Rabin, Benjamin Lam, Ivy Cheng, Robert Fowler, Chris Heyn, Sandra E. Black, Bradley J. Macintosh, Simon J. Graham, Tom A. Schweizer
Summary: This study investigates the neurophysiological mechanisms underlying post-COVID headache, finding suppressed scaling properties in the brain activity of individuals with persistent headache compared to those without headache. This finding suggests a potential biomarker specific to post-COVID headache.
BRAIN AND BEHAVIOR
(2023)
Meeting Abstract
Clinical Neurology
L. Lee, I. Vavasour, E. Hernandez-Torres, A. Traboulsee, R. Tam, S. Kolind, T. Schweizer, J. Oh
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Geriatrics & Gerontology
Mila Valcic, Sandra Black, Morris Freedman, Michael Borrie, Andrew Frank, Sanjeev Kumar, Stephen Pasternak, Bruce Pollock, Tarek Rajji, Dallas Seitz, David Tang-Wai, Carmela Tartaglia, Mario Masellis, Anthony Lang, David Breen, David Grimes, Mandar Jog, Connie Marras, Rick Swartz, Gustavo Saposnik, Donna Kwan, Brian Tan, Rob Hegele, Allison A. Dilliott, John Robinson, Ekaterina Rogaeva, Sali Farhan, Paula McLaughlin, Stephen Strother, Malcolm Binns, Thomas Steeves, Pawel Kostyrko, Komal Talib, Luis Fornazzari, Nathan Churchill, Tom A. Schweizer, David G. Munoz, Corinne E. Fischer
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
