A lysosome-targeted DNA nanodevice selectively targets macrophages to attenuate tumours

Tissue-specific targeting of DNA nanodevices in a multicellular living organism

(2021) Kasturi Chakraborty et al.   eLife

DNA-based fluorescent probes of NOS2 activity in live brains

(2020) Aneesh T. Veetil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer

(2019) Sunil Singhal et al.   Science Translational Medicine

DNA nanodevices map enzymatic activity in organelles

(2019) Krishna Dan et al.   Nature Nanotechnology

Anti-PD-L1 treatment results in functional remodeling of the macrophage compartment

(2019) Huizhong Xiong et al.   CANCER RESEARCH

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Obesity and Insulin Resistance Promote Atherosclerosis through an IFNγ-Regulated Macrophage Protein Network

(2018) Catherine A. Reardon et al.   Cell Reports

Current Concepts of Antigen Cross-Presentation

(2018) Maria Embgenbroich et al.   Frontiers in Immunology

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

A pH-correctable, DNA-based fluorescent reporter for organellar calcium

(2018) Nagarjun Narayanaswamy et al.   NATURE METHODS

A DNA nanomachine chemically resolves lysosomes in live cells

(2018) KaHo Leung et al.   Nature Nanotechnology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes

(2018) Yoelys Cruz-Leal et al.   Frontiers in Immunology

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

High lumenal chloride in the lysosome is critical for lysosome function

(2017) Kasturi Chakraborty et al.   eLife

Near Infrared-Guided Smart Nanocarriers for MicroRNA-Controlled Release of Doxorubicin/siRNA with Intracellular ATP as Fuel

(2016) Penghui Zhang et al.   ACS Nano

DNA-Programmed Quantum Dot Polymerization for Ultrasensitive Molecular Imaging of Cancer Cells

(2016) Zhi Li et al.   ANALYTICAL CHEMISTRY

Role of tumor-associated macrophages in human malignancies: friend or foe?

(2016) Motohiro Takeya et al.   PATHOLOGY INTERNATIONAL

Myeloid Cells as Targets for Therapy in Solid Tumors

(2015) Tiziana Cotechini et al.   CANCER JOURNAL

A Deeper Look into Comet—Implementation and Features

(2015) Jimmy K. Eng et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

“Of Mice and Men”: Arginine Metabolism in Macrophages

(2014) Anita C. Thomas et al.   Frontiers in Immunology

Understanding the Biology of Antigen Cross-Presentation for the Design of Vaccines Against Cancer

(2014) Cynthia M. Fehres et al.   Frontiers in Immunology

Zbtb46expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

(2012) Ansuman T. Satpathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Unique Proteomic Signatures Distinguish Macrophages and Dendritic Cells

(2012) Lev Becker et al.   PLoS One

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

(2012) K. Schroder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice

(2011) Aarthi Gopinathan et al.   GUT

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

Anti-Leukemia Activity of In Vitro-Expanded Human Gamma Delta T Cells in a Xenogeneic Ph+ Leukemia Model

(2011) Gabrielle M. Siegers et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Immunomodulatory effects of cyclophosphamide and implementations for vaccine design

(2011) Antonella Sistigu et al.   Seminars in Immunopathology

An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism

(2011) Sunaina Surana et al.   Nature Communications

PepC: proteomics software for identifying differentially expressed proteins based on spectral counting

(2010) N. L. Heinecke et al.   BIOINFORMATICS

A Macrophage Sterol-Responsive Network Linked to Atherogenesis

(2010) Lev Becker et al.   Cell Metabolism

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE