A DNA nanomachine chemically resolves lysosomes in live cells

Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases

(2018) John Devany et al.   NANO LETTERS

Whole-Cell Scale Dynamic Organization of Lysosomes Revealed by Spatial Statistical Analysis

(2018) Qinle Ba et al.   Cell Reports

Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

(2017) Daniel S Ory et al.   LANCET

Types A and B Niemann-Pick disease

(2017) Edward H. Schuchman et al.   MOLECULAR GENETICS AND METABOLISM

Cell-targetable DNA nanocapsules for spatiotemporal release of caged bioactive small molecules

(2017) Aneesh T. Veetil et al.   Nature Nanotechnology

High lumenal chloride in the lysosome is critical for lysosome function

(2017) Kasturi Chakraborty et al.   eLife

Nucleic Acid–Based Nanodevices in Biological Imaging

(2016) Kasturi Chakraborty et al.   Annual Review of Biochemistry

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

Quantum dot-loaded monofunctionalized DNA icosahedra for single-particle tracking of endocytic pathways

(2016) Dhiraj Bhatia et al.   Nature Nanotechnology

Rational design of a quantitative, pH-insensitive, nucleic acid based fluorescent chloride reporter

(2016) Ved Prakash et al.   Chemical Science

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

Design of ultrasensitive DNA-based fluorescent pH sensitive nanodevices

(2015) Saheli Halder et al.   Nanoscale

A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells

(2015) Sonali Saha et al.   Nature Nanotechnology

Designing DNA nanodevices for compatibility with the immune system of higher organisms

(2015) Sunaina Surana et al.   Nature Nanotechnology

ClC-3 Is an Intracellular Chloride/Proton Exchanger with Large Voltage-Dependent Nonlinear Capacitance

(2013) Raul E. Guzman et al.   ACS Chemical Neuroscience

A method to study in vivo stability of DNA nanostructures

(2013) Sunaina Surana et al.   METHODS

Recombinant antibody mediated delivery of organelle-specific DNA pH sensors along endocytic pathways

(2013) Souvik Modi et al.   Nanoscale

Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell

(2013) Souvik Modi et al.   Nature Nanotechnology

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Challenges and opportunities for structural DNA nanotechnology

(2011) Andre V. Pinheiro et al.   Nature Nanotechnology

A synthetic icosahedral DNA-based host–cargo complex for functional in vivo imaging

(2011) Dhiraj Bhatia et al.   Nature Communications

An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism

(2011) Sunaina Surana et al.   Nature Communications

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor

(2010) Daniele Arosio et al.   NATURE METHODS

Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation

(2010) S. Weinert et al.   SCIENCE

Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes

(2009) Richard J. Cenedella   LIPIDS

A DNA nanomachine that maps spatial and temporal pH changes inside living cells

(2009) Souvik Modi et al.   Nature Nanotechnology

Melanosomes at a glance

(2008) C. Wasmeier et al.   JOURNAL OF CELL SCIENCE

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY