SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France

(2021) Julie Toubiana et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Switzerland

(2021) Athina Fouriki et al.   Frontiers in Pediatrics

A case series of children and young people admitted to a tertiary care hospital in Germany with COVID-19

(2021) Jonathan Remppis et al.   BMC INFECTIOUS DISEASES

Multisystem inflammatory syndrome in children during the COVID-19 pandemic in Turkey: first report from the Eastern Mediterranean

(2021) Yasemin Ozsurekci et al.   CLINICAL RHEUMATOLOGY

Comparison of baseline laboratory findings of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis and multisystem inflammatory syndrome in children

(2021) Fatma Aydın et al.   International Journal of Rheumatic Diseases

Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children

(2021) Naïm Ouldali et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

(2021) Paul Bastard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Acute Appendicitis Mimicking Multisystem Inflammatory Syndrome in Children: Case Report and Review of the Literature

(2021) Zahraa Al Lawati et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

(2021) Laura A. Vella et al.   Science Immunology

Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease

(2021) Ana Esteve-Sole et al.   JOURNAL OF CLINICAL INVESTIGATION

Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection

(2020) Stuart G. Tangye et al.   BLOOD

Pediatric Hemophagocytic Lymphohistiocytosis (HLH)

(2020) Scott Canna et al.   BLOOD

Systemic Inflammation and Myelofibrosis in a Patient with Takenouchi-Kosaki Syndrome due to CDC42 Tyr64Cys Mutation

(2020) Giorgia Bucciol et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease

(2020) Anne H Rowley et al.   JOURNAL OF INFECTIOUS DISEASES

Lethal Infectious Diseases as Inborn Errors of Immunity: Toward a Synthesis of the Germ and Genetic Theories

(2020) Jean-Laurent Casanova et al.   Annual Review of Pathology-Mechanisms of Disease

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

(2020) Jean-Laurent Casanova et al.   CELL

Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic

(2020) Zahra Belhadjer et al.   CIRCULATION

A framework for understanding Kawasaki disease pathogenesis

(2020) Mindy S. Lo   CLINICAL IMMUNOLOGY

Immunogenetics of Kawasaki disease

(2020) Rajni Kumrah et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?

(2020) Jean-Laurent Casanova et al.   HUMAN GENETICS

Type I IFN immunoprofiling in COVID-19 patients

(2020) Sophie Trouillet-Assant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Growing Spectrum of Human Diseases Caused by Inherited CDC42 Mutations

(2020) Helen C. Su et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Epidemiology, Treatments, and Cardiac Complications in Patients with Kawasaki Disease: The Nationwide Survey in Japan, 2017–2018

(2020) Ryusuke Ae et al.   JOURNAL OF PEDIATRICS

Erythema multiforme and Kawasaki disease associated with COVID‐19 infection in children

(2020) P. Labé et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Kawasaki-like disease: emerging complication during the COVID-19 pandemic

(2020) Russell M Viner et al.   LANCET

Hyperinflammatory shock in children during COVID-19 pandemic

(2020) Shelley Riphagen et al.   LANCET

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

(2020) Lucio Verdoni et al.   LANCET

SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children

(2020) Francesco Licciardi et al.   PEDIATRICS

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

(2020) Annemarie B Docherty et al.   BMJ-British Medical Journal

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

(2020) Marie Pouletty et al.   ANNALS OF THE RHEUMATIC DISEASES

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain

(2020) Cinta Moraleda et al.   CLINICAL INFECTIOUS DISEASES

Dermatological manifestation of pediatrics multisystem inflammatory syndrome associated with COVID ‐19 in a 3‐year‐old girl

(2020) Can Yilmaz Yozgat et al.   Dermatologic Therapy

SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020

(2020) Alexandre Belot et al.   Eurosurveillance

Gastrointestinal symptoms as a major presentation component of a novel multisystem inflammatory syndrome in children (MIS-C) that is related to COVID-19: a single center experience of 44 cases

(2020) Jonathan Miller et al.   GASTROENTEROLOGY

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

(2020) Elizabeth Whittaker et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City

(2020) Eva W. Cheung et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2–Related Inflammatory Multisystem Syndrome in Children

(2020) Brian W. McCrindle et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

COVID‐19 multisystem inflammatory syndrome in three teenagers with confirmed SARS‐CoV‐2 infection

(2020) Khuen Foong Ng et al.   JOURNAL OF MEDICAL VIROLOGY

Hyperinflammatory shock related to COVID ‐19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran

(2020) Ahmad Bahrami et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Characteristics, Cardiac Involvement, and Outcomes of Multisystem Inflammatory Disease of Childhood (MIS-C) Associated with SARS-CoV-2 Infection

(2020) Christine A. Capone et al.   JOURNAL OF PEDIATRICS

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2: A Systematic Review

(2020) Joseph Y. Abrams et al.   JOURNAL OF PEDIATRICS

Longitudinal Echocardiographic Assessment of Coronary Arteries and Left Ventricular Function Following Multisystem Inflammatory Syndrome in Children (MIS-C)

(2020) Simone Jhaveri et al.   JOURNAL OF PEDIATRICS

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

(2020) Leora R. Feldstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multisystem Inflammatory Syndrome in Children in New York State

(2020) Elizabeth M. Dufort et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multi-system Inflammatory Syndrome in Children & Adolescents (MIS-C): A Systematic Review of Clinical features and presentation

(2020) Trisha Radia et al.   Paediatric Respiratory Reviews

Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital

(2020) Tristan Ramcharan et al.   PEDIATRIC CARDIOLOGY

Cytokine Profile in an Adolescent With Pediatric Multisystem Inflammatory Syndrome Temporally Related to COVID-19

(2020) Danilo Buonsenso et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Pediatric Inflammatory Multisystem Syndrome With Central Nervous System Involvement and Hypocomplementemia Following SARS-COV-2 Infection

(2020) Tslil Regev et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series

(2020) Eléonore Blondiaux et al.   RADIOLOGY

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study

(2020) Julie Toubiana et al.   BMJ-British Medical Journal

Covid-19 in Peru: from supervised walks for children to the first case of Kawasaki-like syndrome

(2020) Jaime A Yáñez et al.   BMJ-British Medical Journal

Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19

(2020) Paraskevi Theocharis et al.   European Heart Journal-Cardiovascular Imaging

Focus on “COVID Toes”

(2020) Claudia Hernandez et al.   JAMA Dermatology

Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children

(2020) Omar Abdel-Mannan et al.   JAMA Neurology

American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS‐C) Associated with SARS‐CoV‐2 and Hyperinflammation in COVID‐19. Version 1

(2020) Lauren A. Henderson et al.   Arthritis & Rheumatology

Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19

(2020) Adam Klocperk et al.   Frontiers in Immunology

COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020

(2020) Shana Godfred-Cato et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report

(2020) Elie Cogan et al.   Frontiers in Medicine

Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis

(2020) Naim Ouldali et al.   Lancet Child & Adolescent Health

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study

(2020) Florian Götzinger et al.   Lancet Child & Adolescent Health

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study

(2020) Patrick Davies et al.   Lancet Child & Adolescent Health

Multisystem inflammatory syndrome associated with COVID-19 in children in Pakistan

(2020) Masood Sadiq et al.   Lancet Child & Adolescent Health

Pediatric inflammatory multisystem syndrome temporally associated with COVID-19: a spectrum of diseases with many names

(2020) Herman Tam et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

(2020) Camila Rosat Consiglio et al.   CELL

Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)

(2020) Conor N. Gruber et al.   CELL

Low-Dose Dexamethasone Following IVIG in Pediatric Inflammatory Multisystem Syndrome in Temporal Association with COVID-19 (PIMS-TC)

(2020) Priyanka Meena et al.   INDIAN JOURNAL OF PEDIATRICS

Multisystem Inflammatory Syndrome in Children Associated with COVID 19 Treated with Oral Steroid

(2020) Mukesh Kumar Jain et al.   INDIAN JOURNAL OF PEDIATRICS

Neurological Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS)

(2020) Sagar S. Lad et al.   INDIAN JOURNAL OF PEDIATRICS

Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children

(2020) Pui Y. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2

(2020) Caroline Diorio et al.   JOURNAL OF CLINICAL INVESTIGATION

Multisystem Inflammatory Syndrome in Children (MIS-C) in an Adolescent that Developed Coronary Aneurysms: A Case Report and Review of the Literature

(2020) Cole Nelson et al.   JOURNAL OF EMERGENCY MEDICINE

Association of an IGHV3-66 gene variant with Kawasaki disease

(2020) Todd A. Johnson et al.   JOURNAL OF HUMAN GENETICS

Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children

(2020) Kevin G. Friedman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Echocardiographic Findings in Pediatric Multisystem Inflammatory Syndrome Associated With COVID-19 in the United States

(2020) Daisuke Matsubara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

(2020) Michael J. Carter et al.   NATURE MEDICINE

Acute Appendicitis in Multisystem Inflammatory Syndrome in Children With COVID-19

(2020) Juanita Lishman et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Multisystem Inflammatory Syndrome (MIS-C) Surveillance and COVID-19 in Latin America

(2020) Rolando Ulloa-Gutierrez et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Multisystem Inflammatory Syndrome Associated With Coronavirus Disease in Children

(2020) Emmerson C. F. de Farias et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

(2020) Mary Hongying Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

(2020) Olivia V Swann et al.   BMJ-British Medical Journal

Cardiac Abnormalities Seen in Pediatric Patients During the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic: An International Experience

(2020) Bradley C. Clark et al.   Journal of the American Heart Association

Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March–August 2020

(2020) Sapna Bamrah Morris et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Presentation, Treatment Response and Short-Term Outcomes in Paediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS)

(2020) Susanna Felsenstein et al.   Journal of Clinical Medicine

SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome

(2020) Marisa Dolhnikoff et al.   Lancet Child & Adolescent Health

Multisystem inflammatory syndrome in children in South Africa

(2020) Kate Webb et al.   Lancet Child & Adolescent Health

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process

(2020) Rachel Harwood et al.   Lancet Child & Adolescent Health

Addition of Corticosteroids to Immunoglobulins Is Associated With Recovery of Cardiac Function in Multi-Inflammatory Syndrome in Children

(2020) Zahra Belhadjer et al.   CIRCULATION

Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children

(2020) Tarek Alsaied et al.   CIRCULATION

Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe

(2020) Israel Valverde et al.   CIRCULATION

Gastrointestinal Symptoms Followed by Shock in a Febrile 7-Year-Old Child during the COVID-19 Pandemic

(2020) Slimane Allali et al.   CLINICAL CHEMISTRY

Time Course of Coronary Artery Aneurysms in Kawasaki Disease

(2020) Etsuko Tsuda et al.   JOURNAL OF PEDIATRICS

Multisystem Inflammatory Syndrome in Children: An International Survey

(2020) Carles Bautista-Rodriguez et al.   PEDIATRICS

Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance

(2020) Chris Gale et al.   Lancet Child & Adolescent Health

Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study

(2020) Fernanda Lima-Setta et al.   Jornal de Pediatria

Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition

(2019) Yandie Li et al.   Pediatric Rheumatology

Severe autoinflammation in 4 patients with C-terminal variants in cell division control protein 42 homolog (CDC42) successfully treated with IL-1β inhibition

(2019) Yael Gernez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kawasaki Disease: The Role of Immune Complexes Revisited

(2019) Stephanie Menikou et al.   Frontiers in Immunology

A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function

(2019) Michael T. Lam et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kawasaki Disease

(2018) Mary Beth F. Son et al.   PEDIATRICS IN REVIEW

How Should We Classify Kawasaki Disease?

(2018) Edoardo Marrani et al.   Frontiers in Immunology

Dissecting Kawasaki disease: a state-of-the-art review

(2017) S. M. Dietz et al.   EUROPEAN JOURNAL OF PEDIATRICS

Kawasaki disease: epidemiology and the lessons from it

(2017) Yosikazu Nakamura   International Journal of Rheumatic Diseases

A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease

(2017) Jae-Jung Kim et al.   JOURNAL OF HUMAN GENETICS

How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis

(2017) Ellen Brisse et al.   Frontiers in Immunology

Kawasaki Disease

(2016) Jane W. Newburger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates

(2015) Jieun Shin et al.   Science Translational Medicine

Markers of a recent bocavirus infection in children with Kawasaki disease: “A year prospective study”

(2014) F. Bajolle et al.   PATHOLOGIE BIOLOGIE

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

(2012) Yi-Ching Lee et al.   NATURE GENETICS

A genome-wide association study identifies three new risk loci for Kawasaki disease

(2012) Yoshihiro Onouchi et al.   NATURE GENETICS

Familial and Acquired Hemophagocytic Lymphohistiocytosis

(2011) G.E. Janka   Annual Review of Medicine

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

(2011) Chiea Chuen Khor et al.   NATURE GENETICS

The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease

(2010) S. Jia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hospitalizations for Kawasaki Syndrome Among Children in the United States, 1997–2007

(2010) Robert C. Holman et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

CONCOMITANT RESPIRATORY VIRAL INFECTIONS IN CHILDREN WITH KAWASAKI DISEASE

(2010) Alejandro Jordan-Villegas et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Kawasaki Disease Lacks Association With Human Coronavirus NL63 and Human Bocavirus

(2009) Christian Lehmann et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Molecular Genetics of Kawasaki Disease

(2009) Yoshihiro Onouchi   PEDIATRIC RESEARCH

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Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD