A generalized linear mixed model association tool for biobank-scale data

A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts

(2021) Guiyan Ni et al.   BIOLOGICAL PSYCHIATRY

Computationally efficient whole-genome regression for quantitative and binary traits

(2021) Joelle Mbatchou et al.   NATURE GENETICS

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

(2020) Jamie E. Craig et al.   NATURE GENETICS

Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts

(2020) Wei Zhou et al.   NATURE GENETICS

ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies

(2019) Yaowu Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A resource-efficient tool for mixed model association analysis of large-scale data

(2019) Longda Jiang et al.   NATURE GENETICS

Improved polygenic prediction by Bayesian multiple regression on summary statistics

(2019) Luke R. Lloyd-Jones et al.   Nature Communications

Transformation of Summary Statistics from Linear Mixed Model Association on All-or-None Traits to Odds Ratio

(2018) Luke R. Lloyd-Jones et al.   GENETICS

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Mixed-model association for biobank-scale datasets

(2018) Po-Ru Loh et al.   NATURE GENETICS

Transformation of Summary Statistics from Linear Mixed Model Association on All-or-None Traits to Odds Ratio

(2018) Luke R. Lloyd-Jones et al.   GENETICS

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Software Application Profile: PHESANT: a tool for performing automated phenome scans in UK Biobank

(2017) Louise AC Millard et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

(2017) Joanna M M Howson et al.   NATURE GENETICS

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models

(2016) Han Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

(2016) William J. Astle et al.   CELL

Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations

(2016) Sara L. Pulit et al.   GENETIC EPIDEMIOLOGY

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

(2016) Wouter van Rheenen et al.   NATURE GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

A new tool called DISSECT for analysing large genomic data sets using a Big Data approach

(2015) Oriol Canela-Xandri et al.   Nature Communications

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies

(2013) Matti Pirinen et al.   Annals of Applied Statistics

Confirmation of the HOXB13 G84E Germline Mutation in Familial Prostate Cancer

(2012) J. P. Breyer et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A Population-based Assessment of Germline HOXB13 G84E Mutation and Prostate Cancer Risk

(2012) Robert Karlsson et al.   EUROPEAN UROLOGY

Rapid variance components–based method for whole-genome association analysis

(2012) Gulnara R Svishcheva et al.   NATURE GENETICS

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Germline Mutations inHOXB13and Prostate-Cancer Risk

(2012) Charles M. Ewing et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

(2011) Tomomitsu Hirota et al.   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mixed linear model approach adapted for genome-wide association studies

(2010) Zhiwu Zhang et al.   NATURE GENETICS

Variance component model to account for sample structure in genome-wide association studies

(2010) Hyun Min Kang et al.   NATURE GENETICS

Efficient Control of Population Structure in Model Organism Association Mapping

(2008) H. M. Kang et al.   GENETICS