POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis

Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair

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DSS1 and ssDNA regulate oligomerization of BRCA2

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The Tumor Suppressor PALB2: Inside Out

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53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

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Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response

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ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination

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Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

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Beyond PARP—POLθ as an anticancer target

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Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

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DNA polymerase θ (POLQ), double-strand break repair, and cancer

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Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability

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Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

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RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

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Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

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Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

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Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

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Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

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A second DNA binding site in human BRCA2 promotes homologous recombination

(2016) Catharina von Nicolai et al.   Nature Communications

Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

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Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination

(2016) Kritika Hanamshet et al.   Genes

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

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γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

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Purified human BRCA2 stimulates RAD51-mediated recombination

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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes

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Rad52 inactivation is synthetically lethal with BRCA2 deficiency

(2010) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

(2009) Aura Carreira et al.   CELL

Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes

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Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics