Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration

The WAVE complex associates with sites of saddle membrane curvature

(2021) Anne Pipathsouk et al.   JOURNAL OF CELL BIOLOGY

Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions

(2021) Thomas Orré et al.   Nature Communications

Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration

(2021) Ah-Lai Law et al.   Nature Communications

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

(2020) Luyan Cao et al.   NATURE CELL BIOLOGY

Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures

(2020) Sophie Massou et al.   NATURE CELL BIOLOGY

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

Torsional stress generated by ADF/cofilin on cross-linked actin filaments boosts their severing

(2019) Hugo Wioland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion

(2019) Amine Mehidi et al.   CURRENT BIOLOGY

Actin dynamics in cell migration

(2019) Matthias Schaks et al.   Essays in Biochemistry

On the relation between filament density, force generation and protrusion rate in mesenchymal cell motility

(2018) Setareh Dolati et al.   MOLECULAR BIOLOGY OF THE CELL

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

(2018) Loic Fort et al.   NATURE CELL BIOLOGY

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

(2018) Matthias Schaks et al.   CURRENT BIOLOGY

Mechanobiology of collective cell behaviours

(2017) Benoit Ladoux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vinculin forms a directionally asymmetric catch bond with F-actin

(2017) Derek L. Huang et al.   SCIENCE

FMNL formins boost lamellipodial force generation

(2017) Frieda Kage et al.   Nature Communications

Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion

(2017) Rotem Gura Sadovsky et al.   Cell Reports

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

(2017) Baoyu Chen et al.   eLife

FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42

(2017) Frieda Kage et al.   Scientific Reports

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Amplification of actin polymerization forces

(2016) Serge Dmitrieff et al.   JOURNAL OF CELL BIOLOGY

Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin

(2016) Ingrid Chamma et al.   Nature Communications

Local F-actin Network Links Synapse Formation and Axon Branching

(2014) Poh Hui Chia et al.   CELL

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

(2014) Baoyu Chen et al.   CELL

Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton

(2014) Xing Judy Chen et al.   DEVELOPMENTAL CELL

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion

(2014) Anaël Chazeau et al.   EMBO JOURNAL

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arp2/3-Mediated Actin-Based Motility: A Tail of Pathogen Abuse

(2013) Matthew D. Welch et al.   Cell Host & Microbe

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

(2013) Ah-Lai Law et al.   JOURNAL OF CELL BIOLOGY

A Highly Specific Gold Nanoprobe for Live-Cell Single-Molecule Imaging

(2013) Cécile Leduc et al.   NANO LETTERS

Inhibitory signalling to the Arp2/3 complex steers cell migration

(2013) Irene Dang et al.   NATURE

Real-Time Analysis and Visualization for Single-Molecule Based Super-Resolution Microscopy

(2013) Adel Kechkar et al.   PLoS One

Tension modulates actin filament polymerization mediated by formin and profilin

(2013) N. Courtemanche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formin mDia1 senses and generates mechanical forces on actin filaments

(2013) Antoine Jégou et al.   Nature Communications

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

(2013) Benjamin A Smith et al.   eLife

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42

(2012) Jennifer Block et al.   CURRENT BIOLOGY

Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging

(2012) A. Millius et al.   JOURNAL OF CELL SCIENCE

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

FMNL3 FH2–actin structure gives insight into formin-mediated actin nucleation and elongation

(2012) Morgan E Thompson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wavelet analysis for single molecule localization microscopy

(2012) I. Izeddin et al.   OPTICS EXPRESS

Actin filament curvature biases branching direction

(2012) V. I. Risca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Cortactin Releases the Brakes in Actin- Based Motility by Enhancing WASP-VCA Detachment from Arp2/3 Branches

(2011) Orit Siton et al.   CURRENT BIOLOGY

Clathrin is required for Scar/Wave-mediated lamellipodium formation

(2011) J. J. Gautier et al.   JOURNAL OF CELL SCIENCE

Optical tweezers study life under tension

(2011) Furqan M Fazal et al.   Nature Photonics

Assembly of filopodia by the formin FRL2 (FMNL3)

(2010) Elizabeth S. Harris et al.   Cytoskeleton

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly

(2009) Andres M. Lebensohn et al.   MOLECULAR CELL

The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility

(2009) Ina Weisswange et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner

(2008) H. Hirata et al.   JOURNAL OF CELL SCIENCE

Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2

(2008) W. Abou-Kheir et al.   JOURNAL OF CELL SCIENCE

Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front

(2008) Stefan A. Koestler et al.   NATURE CELL BIOLOGY

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

(2008) Suliana Manley et al.   NATURE METHODS

Free Brick1 Is a Trimeric Precursor in the Assembly of a Functional Wave Complex

(2008) Emmanuel Derivery et al.   PLoS One