Actin dynamics in cell migration

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins

(2019) Christof Litschko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion

(2019) Amine Mehidi et al.   CURRENT BIOLOGY

Reconsidering an active role for G-actin in cytoskeletal regulation

(2018) Kristen Skruber et al.   JOURNAL OF CELL SCIENCE

Species-Specific Functions of Twinfilin in Actin Filament Depolymerization

(2018) Denise M. Hilton et al.   JOURNAL OF MOLECULAR BIOLOGY

Rac1 nanoscale organization on the plasma membrane is driven by lipid binding specificity encoded in the membrane anchor

(2018) Kelsey N. Maxwell et al.   MOLECULAR AND CELLULAR BIOLOGY

Discovery of functional interactions among actin regulators by analysis of image fluctuations in an unperturbed motile cell system

(2018) Tadamoto Isogai et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lamellipodium is a myosin-independent mechanosensor

(2018) Patrick W. Oakes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of actin monomer re-charging by cyclase-associated protein

(2018) Tommi Kotila et al.   Nature Communications

Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis

(2018) Robert S. Fischer et al.   DEVELOPMENTAL BIOLOGY

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

(2018) Matthias Schaks et al.   CURRENT BIOLOGY

Time-resolved ultrastructure of the cortical actin cytoskeleton in dynamic membrane blebs

(2018) Aleksandra S. Chikina et al.   JOURNAL OF CELL BIOLOGY

Assembling actin filaments for protrusion

(2018) Klemens Rottner et al.   CURRENT OPINION IN CELL BIOLOGY

WASP family proteins and formins compete in pseudopod- and bleb-based migration

(2017) Andrew J. Davidson et al.   JOURNAL OF CELL BIOLOGY

Actin assembly mechanisms at a glance

(2017) Klemens Rottner et al.   JOURNAL OF CELL SCIENCE

Structural Basis of Arp2/3 Complex Inhibition by GMF, Coronin, and Arpin

(2017) Olga S. Sokolova et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays

(2017) Stefan Brühmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling

(2017) Amanda Remorino et al.   Cell Reports

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

(2017) Baoyu Chen et al.   eLife

Cellular functions of the ADF/cofilin family at a glance

(2016) Georgios Kanellos et al.   JOURNAL OF CELL SCIENCE

The WH2 Domain and Actin Nucleation: Necessary but Insufficient

(2016) Roberto Dominguez   TRENDS IN BIOCHEMICAL SCIENCES

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

(2016) Kate M. Byrne et al.   Cell Systems

Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics

(2016) Katrin Martin et al.   Scientific Reports

Filopodia in cell adhesion, 3D migration and cancer cell invasion

(2015) Guillaume Jacquemet et al.   CURRENT OPINION IN CELL BIOLOGY

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex

(2015) T. Isogai et al.   JOURNAL OF CELL SCIENCE

A mechanism of leading-edge protrusion in the absence of Arp2/3 complex

(2015) Praveen Suraneni et al.   MOLECULAR BIOLOGY OF THE CELL

The role of signalling and the cytoskeleton during Vaccinia Virus egress

(2015) Flavia Leite et al.   VIRUS RESEARCH

Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A

(2015) Federico Iseppon et al.   Frontiers in Cellular Neuroscience

A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement

(2015) Nagendran Ramalingam et al.   Nature Communications

Two Functionally Distinct Sources of Actin Monomers Supply the Leading Edge of Lamellipodia

(2015) Eric A. Vitriol et al.   Cell Reports

Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments

(2015) Scott D Hansen et al.   eLife

Aip1 Destabilizes Cofilin-Saturated Actin Filaments by Severing and Accelerating Monomer Dissociation from Ends

(2014) Ambika V. Nadkarni et al.   CURRENT BIOLOGY

Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton

(2014) Xing Judy Chen et al.   DEVELOPMENTAL CELL

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

(2014) Sreeja B. Asokan et al.   DEVELOPMENTAL CELL

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Capping protein regulators fine-tune actin assembly dynamics

(2014) Marc Edwards et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs

(2014) Malgorzata Boczkowska et al.   Nature Communications

Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility

(2013) Chi Wai Lee et al.   CURRENT BIOLOGY

The role and regulation of blebs in cell migration

(2013) Ewa K Paluch et al.   CURRENT OPINION IN CELL BIOLOGY

How filopodia pull: What we know about the mechanics and dynamics of filopodia

(2013) Thomas Bornschlögl   Cytoskeleton

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

(2013) Ah-Lai Law et al.   JOURNAL OF CELL BIOLOGY

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

(2013) A. Steffen et al.   JOURNAL OF CELL SCIENCE

Formins at a glance

(2013) Dennis Breitsprecher et al.   JOURNAL OF CELL SCIENCE

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin

(2013) Stefan A. Koestler et al.   MOLECULAR BIOLOGY OF THE CELL

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

(2013) Benjamin A Smith et al.   eLife

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

(2012) Praveen Suraneni et al.   JOURNAL OF CELL BIOLOGY

Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging

(2012) A. Millius et al.   JOURNAL OF CELL SCIENCE

FilGAP, a Rho/Rho-associated protein kinase–regulated GTPase-activating protein for Rac, controls tumor cell migration

(2012) Koji Saito et al.   MOLECULAR BIOLOGY OF THE CELL

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell mechanics control rapid transitions between blebs and lamellipodia during migration

(2012) M. Bergert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin Network Architecture Can Determine Myosin Motor Activity

(2012) A.-C. Reymann et al.   SCIENCE

Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation

(2011) Jana Stastna et al.   CELL RESEARCH

Cofilin Tunes the Nucleotide State of Actin Filaments and Severs at Bare and Decorated Segment Boundaries

(2011) Cristian Suarez et al.   CURRENT BIOLOGY

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Arp2/3 complex is bound and activated by two WASP proteins

(2011) S. B. Padrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

The role of formins in filopodia formation

(2009) Harry Mellor   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

(2009) S. Vemula et al.   BLOOD

Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly

(2009) Syed A. Rizvi et al.   CHEMISTRY & BIOLOGY

Cofilin Dissociates Arp2/3 Complex and Branches from Actin Filaments

(2009) Chikio Chan et al.   CURRENT BIOLOGY

Formin-like 1 (FMNL1) Is Regulated by N-terminal Myristoylation and Induces Polarized Membrane Blebbing

(2009) Yanyan Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ena/VASP: towards resolving a pointed controversy at the barbed end

(2009) J. E. Bear et al.   JOURNAL OF CELL SCIENCE

Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2

(2009) Tom D. Bunney et al.   MOLECULAR CELL

The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility

(2009) Ina Weisswange et al.   NATURE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Coordination of Rho and Rac GTPase Function via p190B RhoGAP

(2008) Rodrigo I. Bustos et al.   CURRENT BIOLOGY

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Filopodia formation induced by active mDia2/Drf3

(2008) J. BLOCK et al.   JOURNAL OF MICROSCOPY

Hierarchical Regulation of WASP/WAVE Proteins

(2008) Shae B. Padrick et al.   MOLECULAR CELL

WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2

(2008) Petra Beli et al.   NATURE CELL BIOLOGY

Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front

(2008) Stefan A. Koestler et al.   NATURE CELL BIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Free Brick1 Is a Trimeric Precursor in the Assembly of a Functional Wave Complex

(2008) Emmanuel Derivery et al.   PLoS One

Arp2 depletion inhibits sheet-like protrusions but not linear protrusions of fibroblasts and lymphocytes

(2008) Susan M. Nicholson-Dykstra et al.   CELL MOTILITY AND THE CYTOSKELETON