Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells

Addressing Patient to Patient Variability for Autologous CAR T Therapies

(2021) Jinlin Jiang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

(2021) Annette B. Vogel et al.   NATURE

Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines

(2021) Kelsey L. Swingle et al.   TRENDS IN MOLECULAR MEDICINE

Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs

(2021) István Tombácz et al.   MOLECULAR THERAPY

The impact of lentiviral vector genome size and producer cell genomic to gag-pol mRNA ratios on packaging efficiency and titre

(2021) Nathan P. Sweeney et al.   Molecular Therapy-Methods & Clinical Development

Retroviral Insertional Mutagenesis in Humans: Evidence for Four Genetic Mechanisms Promoting Expansion of Cell Clones

(2020) Frederic D. Bushman   MOLECULAR THERAPY

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

(2020) Dongrui Wang et al.   Science Translational Medicine

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Vitro-Transcribed mRNA Chimeric Antigen Receptor T Cell (IVT mRNA CAR T) Therapy in Hematologic and Solid Tumor Management: A Preclinical Update

(2020) Thangavelu Soundara Rajan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

(2020) Colby R. Maldini et al.   NATURE MEDICINE

Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies

(2020) Elizabeth L. Siegler et al.   Frontiers in Immunology

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

(2020) N. N. Parayath et al.   Nature Communications

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

(2019) Jessica B. Foster et al.   MOLECULAR THERAPY

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

(2019) Mohamed-Reda Benmebarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging Trends in Chimeric Antigen Receptor T-Cell Immunotherapy in Adults from the Vizient Clinical Database

(2019) Alyssa Hartsell   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Nanoparticles for Nucleic Acid Delivery: Applications in Cancer Immunotherapy

(2019) Alvin J. Mukalel et al.   CANCER LETTERS

Elusive Neurotoxicity in T Cell-Boosting Anticancer Therapies

(2019) Ping-Pin Zheng et al.   TRENDS IN IMMUNOLOGY

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

(2019) Anna K. Blakney et al.   GENE THERAPY

Optimizing CAR-T Cell Manufacturing Processes During Pivotal Clinical Trials

(2019) Seshu Tyagarajan et al.   Molecular Therapy-Methods & Clinical Development

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

(2019) Christopher L. Nobles et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-viral RNA chimeric antigen receptor modified T cells in patients with Hodgkin lymphoma

(2018) Jakub Svoboda et al.   BLOOD

Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

(2018) Gregory L. Beatty et al.   GASTROENTEROLOGY

Purification of mRNA encoding chimeric antigen receptor is critical for generation of robust T cell response

(2018) Jessica Bobula Foster et al.   HUMAN GENE THERAPY

Cationic polymers for non-viral gene delivery to human T cells

(2018) Brynn R. Olden et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice

(2018) He Li et al.   Cell Death & Disease

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System

(2018) Mauro P. Avanzi et al.   Cell Reports

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

(2018) Marco Ruella et al.   NATURE MEDICINE

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Large B-cell Lymphoma

(2018) Najat Bouchkouj et al.   CLINICAL CANCER RESEARCH

Biomaterials for vaccine-based cancer immunotherapy

(2018) Rui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo

(2018) Tia DiTommaso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Novel Anti-CD19 Chimeric Antigen Receptor: A Paradigm for an Affordable CAR T Cell Production at Academic Institutions

(2018) Maria Castella et al.   Molecular Therapy-Methods & Clinical Development

Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells

(2017) Janos L. Tanyi et al.   JOURNAL OF IMMUNOTHERAPY

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA

(2017) Siddharth Patel et al.   NANO LETTERS

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

(2017) Yasmin Granot et al.   SEMINARS IN IMMUNOLOGY

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

(2017) H. F. Moffett et al.   Nature Communications

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

(2017) Julia Tchou et al.   Cancer Immunology Research

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Medical management of side effects related to CAR T cell therapy in hematologic malignancies

(2016) Manjusha Namuduri et al.   Expert Review of Hematology

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Biomaterials for mRNA delivery

(2015) Mohammad Ariful Islam et al.   Biomaterials Science

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure–Activity Relationship, and Implications for siRNA Delivery

(2011) Jingtao Zhang et al.   LANGMUIR

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological Gene Delivery Vehicles: Beyond Viral Vectors

(2009) Yiqi Seow et al.   MOLECULAR THERAPY