Engineering Approaches to Immunotherapy

Modulating Adaptive Immune Responses to Peptide Self-Assemblies

(2012) Jai S. Rudra et al.   ACS Nano

Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab

(2012) M. Klinger et al.   BLOOD

The development of LTi cells

(2012) Marie Cherrier et al.   CURRENT OPINION IN IMMUNOLOGY

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

(2012) Ashley L. St. John et al.   NATURE MATERIALS

Computational modeling of cellular signaling processes embedded into dynamic spatial contexts

(2012) Bastian R Angermann et al.   NATURE METHODS

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving

(2012) N. Varadarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

(2012) H. Kalscheuer et al.   Science Translational Medicine

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Systems Biology in Immunology: A Computational Modeling Perspective

(2011) Ronald N. Germain et al.   Annual Review of Immunology

Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor

(2011) Igor Kuzin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma

(2011) P. A. Moore et al.   BLOOD

Systems analysis of adaptive immunity by utilization of high-throughput technologies

(2011) Sai T Reddy et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Modulation of antibody effector function

(2011) John R. Desjarlais et al.   EXPERIMENTAL CELL RESEARCH

Imaging sialylated tumor cell glycans in vivo

(2011) André A. Neves et al.   FASEB JOURNAL

Dendritic cell control of tolerogenic responses

(2011) Santhakumar Manicassamy et al.   IMMUNOLOGICAL REVIEWS

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells

(2011) Megan J Palmer et al.   IMMUNOLOGY AND CELL BIOLOGY

A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

(2011) Navin Varadarajan et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival

(2011) Max S. Topp et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhancing Protease Activity Assay in Droplet-Based Microfluidics Using a Biomolecule Concentrator

(2011) Chia-Hung Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

(2011) Qunrui Ye et al.   Journal of Translational Medicine

Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells

(2011) Luis J. Cruz et al.   MOLECULAR PHARMACEUTICS

Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

(2011) Matthias T. Stephan et al.   Nano Today

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

Biomaterial-Based Vaccine Induces Regression of Established Intracranial Glioma in Rats

(2011) Omar A. Ali et al.   PHARMACEUTICAL RESEARCH

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

(2011) C. Nembrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis

(2011) Marie Ballester et al.   VACCINE

Intracellular Delivery of a Protein Antigen with an Endosomal-Releasing Polymer Enhances CD8 T-Cell Production and Prophylactic Vaccine Efficacy

(2010) Suzanne Foster et al.   BIOCONJUGATE CHEMISTRY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Systems Vaccinology

(2010) Bali Pulendran et al.   IMMUNITY

Immunogenomics and systems biology of vaccines

(2010) Luigi Buonaguro et al.   IMMUNOLOGICAL REVIEWS

Immunotherapy for Ovarian Cancer: What's Next?

(2010) Lana E. Kandalaft et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Tumor-Induced Myeloid-Derived Suppressor Cell Function by a Nanoparticulated Adjuvant

(2010) A. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection

(2010) Andrej Košmrlj et al.   NATURE

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

(2010) Sai T Reddy et al.   NATURE BIOTECHNOLOGY

Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines

(2010) Tomonori Nochi et al.   NATURE MATERIALS

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells

(2010) J. N. H. Stern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolving concepts of specificity in immune reactions

(2010) H. N. Eisen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis

(2010) S. Bertholet et al.   Science Translational Medicine

Multivalent antibodies: when design surpasses evolution

(2010) Ángel M. Cuesta et al.   TRENDS IN BIOTECHNOLOGY

Lymph node stroma broaden the peripheral tolerance paradigm

(2010) Anne L. Fletcher et al.   TRENDS IN IMMUNOLOGY

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

(2010) Sachiko Hirosue et al.   VACCINE

In vitro stimulation of human influenza-specific CD8+ T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine

(2010) Haifeng Song et al.   VACCINE

PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration

(2010) Armando Stano et al.   VACCINE

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

(2009) Gianpietro Dotti et al.   HUMAN GENE THERAPY

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

(2009) Antonio Manzo et al.   IMMUNOLOGICAL REVIEWS

Fluid Flow Regulates Stromal Cell Organization and CCL21 Expression in a Tissue-Engineered Lymph Node Microenvironment

(2009) A. A. Tomei et al.   JOURNAL OF IMMUNOLOGY

Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response

(2009) N. H. Ruddle et al.   JOURNAL OF IMMUNOLOGY

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice

(2009) O. A. Ali et al.   Science Translational Medicine

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

(2008) Ilaria Marigo et al.   IMMUNOLOGICAL REVIEWS

Tissue-Engineered Spleen Protects Against Overwhelming Pneumococcal Sepsis in a Rodent Model

(2008) Tracy C. Grikscheit et al.   JOURNAL OF SURGICAL RESEARCH

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive detection of therapeutic cytolytic T cells with 18F–FHBG PET in a patient with glioma

(2008) Shahriar S Yaghoubi et al.   Nature clinical practice. Oncology

Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration

(2007) Agnieszka N. Stachowiak et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity

(2007) Darrell J. Irvine et al.   SEMINARS IN IMMUNOLOGY