Charting a global research strategy for progressive MS—An international progressive MS Alliance proposal

Facing the urgency of therapies for progressive MS — a Progressive MS Alliance proposal

(2021) Fernando Dangond et al.   Nature Reviews Neurology

Diagnosis and Treatment of Multiple Sclerosis

(2021) Marisa P. McGinley et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neurofilament light chain in a phase 2 clinical trial of ibudilast in progressive multiple sclerosis

(2021) Robert J Fox et al.   Multiple Sclerosis Journal

Prioritizing progressive MS rehabilitation research: A call from the International Progressive MS Alliance

(2021) Kathleen M Zackowski et al.   Multiple Sclerosis Journal

A New Way to Identify Promising Therapies for Progressive Multiple Sclerosis

(2021) Robert J. Fox et al.   NEUROLOGY

Repurposing Domperidone in Secondary Progressive Multiple Sclerosis

(2021) Marcus W. Koch et al.   NEUROLOGY

A smartphone sensor-based digital outcome assessment of multiple sclerosis

(2021) Xavier Montalban et al.   Multiple Sclerosis Journal

Serum Neurofilament Light Association With Progression in Natalizumab-Treated Patients With Relapsing-Remitting Multiple Sclerosis

(2021) Claire Bridel et al.   NEUROLOGY

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

(2020) Jeremy Chataway et al.   LANCET NEUROLOGY

Biosensors to monitor MS activity

(2020) Jennifer S Graves et al.   Multiple Sclerosis Journal

Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis

(2020) Rosa Cortese et al.   Multiple Sclerosis Journal

Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

(2020) Sabela Rodríguez-Lorenzo et al.   Acta Neuropathologica Communications

Progressive Multiple Sclerosis Is Associated with Faster and Specific Retinal Layer Atrophy

(2020) Elias S. Sotirchos et al.   ANNALS OF NEUROLOGY

Study protocol: improving cognition in people with progressive multiple sclerosis: a multi-arm, randomized, blinded, sham-controlled trial of cognitive rehabilitation and aerobic exercise (COGEx)

(2020) Anthony Feinstein et al.   BMC Neurology

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

(2020) Nina L Fransen et al.   BRAIN

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

(2020) Sunny Malhotra et al.   BRAIN

Plasma neurofilament light levels are associated with the risk of disability in multiple sclerosis

(2020) Ali Manouchehrinia et al.   NEUROLOGY

The 2013 clinical course descriptors for multiple sclerosis

(2020) Fred D. Lublin et al.   NEUROLOGY

Mechanisms underlying progression in multiple sclerosis

(2020) Martina Absinta et al.   CURRENT OPINION IN NEUROLOGY

Measuring outcomes that matter most to people with multiple sclerosis: the role of patient-reported outcomes

(2020) Giampaolo Brichetto et al.   CURRENT OPINION IN NEUROLOGY

Serum neurofilament light as a biomarker in progressive multiple sclerosis

(2020) Raju Kapoor et al.   NEUROLOGY

Association of Sustained Immunotherapy With Disability Outcomes in Patients With Active Secondary Progressive Multiple Sclerosis

(2020) Nathaniel Lizak et al.   JAMA Neurology

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Bruce A C Cree et al.   LANCET NEUROLOGY

Towards treating progressive multiple sclerosis

(2020) Alan Thompson et al.   Nature Reviews Neurology

Long-term evolution of multiple sclerosis iron rim lesions in 7 T MRI

(2020) Assunta Dal-Bianco et al.   BRAIN

Efficacy of high-intensity aerobic exercise on cognitive performance in people with multiple sclerosis: A randomized controlled trial

(2020) Martin Langeskov-Christensen et al.   Multiple Sclerosis Journal

Accurate classification of secondary progression in multiple sclerosis using a decision tree

(2020) Ryan Ramanujam et al.   Multiple Sclerosis Journal

Effects of Ibudilast on MRI Measures in the Phase 2 SPRINT-MS Study

(2020) Robert T. Naismith et al.   NEUROLOGY

Efficacy of high-intensity aerobic exercise on brain MRI measures in multiple sclerosis

(2020) Martin Langeskov-Christensen et al.   NEUROLOGY

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation

(2019) Michael A. Wheeler et al.   CELL

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis

(2019) J. William L. Brown et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

(2019) Hans Lassmann   Frontiers in Immunology

Blood neurofilament light chain as a biomarker of MS disease activity and treatment response

(2019) Jens Kuhle et al.   NEUROLOGY

Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

(2019) Zina-Mary Manjaly et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Blood neurofilament light as a potential endpoint in Phase 2 studies in MS

(2019) Maria Pia Sormani et al.   Annals of Clinical and Translational Neurology

Early complement genes are associated with visual system degeneration in multiple sclerosis

(2019) Kathryn C Fitzgerald et al.   BRAIN

Fluoxetine in progressive multiple sclerosis: The FLUOX-PMS trial

(2019) Melissa Cambron et al.   Multiple Sclerosis Journal

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

(2019) Colm Elliott et al.   BRAIN

Assessment of a home-based standing frame programme in people with progressive multiple sclerosis (SUMS): a pragmatic, multi-centre, randomised, controlled trial and cost-effectiveness analysis

(2019) Jennifer Freeman et al.   LANCET NEUROLOGY

Cortical atrophy accelerates as cognitive decline worsens in multiple sclerosis

(2019) Anand J.C. Eijlers et al.   NEUROLOGY

Telomere Length Is Associated with Disability Progression in Multiple Sclerosis

(2019) Kristen M. Krysko et al.   ANNALS OF NEUROLOGY

Patient-reported outcomes in the spotlight

(2019) The Lancet Neurology   LANCET NEUROLOGY

Deep gray matter volume loss drives disability worsening in multiple sclerosis

(2018) Arman Eshaghi et al.   ANNALS OF NEUROLOGY

Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

(2018) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Progression of regional grey matter atrophy in multiple sclerosis

(2018) Arman Eshaghi et al.   BRAIN

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

(2018) Raju Kapoor et al.   LANCET NEUROLOGY

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis

(2018) Nelly Siller et al.   Multiple Sclerosis Journal

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Unified understanding of MS course is required for drug development

(2018) Timothy Coetzee et al.   Nature Reviews Neurology

Assessing treatment outcomes in multiple sclerosis trials and in the clinical setting

(2018) Carmen Tur et al.   Nature Reviews Neurology

The cortical damage, early relapses, and onset of the progressive phase in multiple sclerosis

(2018) Antonio Scalfari et al.   NEUROLOGY

Steps towards Collective Sustainability in Biomedical Research

(2018) Marco Salvetti et al.   TRENDS IN MOLECULAR MEDICINE

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis

(2018) Nelly Siller et al.   Multiple Sclerosis Journal

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

(2018) Peter Connick et al.   BMJ Open

Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease

(2018) Yuyi You et al.   BRAIN

Unraveling treatment response in multiple sclerosis

(2018) Claudio Gasperini et al.   NEUROLOGY

Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function

(2017) Daniel Ontaneda et al.   LANCET

Accelerating Research Impact in a Learning Health Care System

(2017) Amy M. Kilbourne et al.   MEDICAL CARE

A new role for evoked potentials in MS? Repurposing evoked potentials as biomarkers for clinical trials in MS

(2017) Martin Hardmeier et al.   Multiple Sclerosis Journal

The MSOAC approach to developing performance outcomes to measure and monitor multiple sclerosis disability

(2017) Nicholas G LaRocca et al.   Multiple Sclerosis Journal

“No evident disease activity”: The use of combined assessments in the management of patients with multiple sclerosis

(2017) Gavin Giovannoni et al.   Multiple Sclerosis Journal

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Serum neurofilament is associated with progression of brain atrophy and disability in early MS

(2017) Jens Kuhle et al.   NEUROLOGY

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation

(2017) Veit Rothhammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new role for evoked potentials in MS? Repurposing evoked potentials as biomarkers for clinical trials in MS

(2017) Martin Hardmeier et al.   Multiple Sclerosis Journal

The MSOAC approach to developing performance outcomes to measure and monitor multiple sclerosis disability

(2017) Nicholas G LaRocca et al.   Multiple Sclerosis Journal

“No evident disease activity”: The use of combined assessments in the management of patients with multiple sclerosis

(2017) Gavin Giovannoni et al.   Multiple Sclerosis Journal

Defining secondary progressive multiple sclerosis

(2016) Johannes Lorscheider et al.   BRAIN

Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial

(2016) Fred Lublin et al.   LANCET

The EDSS-Plus, an improved endpoint for disability progression in secondary progressive multiple sclerosis

(2016) Diego Cadavid et al.   Multiple Sclerosis Journal

Progressive MS Alliance Industry Forum: Maximizing Collective Impact To Enable Drug Development

(2016) P. Zaratin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The EDSS-Plus, an improved endpoint for disability progression in secondary progressive multiple sclerosis

(2016) Diego Cadavid et al.   Multiple Sclerosis Journal

Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis

(2015) Martina Absinta et al.   NEUROLOGY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

HLA-DRB1*15 influences the development of brain tissue damage in early PPMS

(2014) C. Tur et al.   NEUROLOGY

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

(2012) Robert J Fox et al.   Multiple Sclerosis Journal

The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability

(2010) Antonio Scalfari et al.   BRAIN