Article
Clinical Neurology
Henrik Ehrhardt, Jeffrey Lambe, Hussein Moussa, Eleni S. Vasileiou, Grigorios Kalaitzidis, Olwen C. Murphy, Angeliki G. Filippatou, Nicole Pellegrini, Morgan Douglas, Simidele Davis, Natalia Nagy, Agustina Quiroga, Chen Hu, Alexandra Zambriczki Lee, Anna Duval, Kathryn C. Fitzgerald, Jerry L. Prince, Peter A. Calabresi, Elias S. Sotirchos, Robert Bermel, Shiv Saidha
Summary: In this post hoc analysis of the SPRINT-MS trial, it was found that ibudilast therapy can slow down GCIPL atrophy in PMS, particularly in the PPMS cohort. The rates of GCIPL, INL, and ONL atrophy were correlated with whole brain atrophy rates.
Article
Physiology
Ghaith Aloui, Souhail Hermassi, Thomas Bartels, Lawrence D. Hayes, El Ghali Bouhafs, Mohamed Souhaiel Chelly, Rene Schwesig
Summary: This study examined the impact of 8 weeks of biweekly combined plyometric and short sprint training on the performance of youth male soccer players. The results showed that the experimental group demonstrated significant improvements in jump, sprint, change-of-direction ability, repeated shuttle sprint ability, and dynamic balance compared to the control group.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Olivia W. Stanley, Alan B. Kuurstra, L. Martyn Klassen, Ravi S. Menon, Joseph S. Gati
Summary: High-resolution functional MRI studies have proven to be a powerful tool in probing the functional organization of the human cortex, with ongoing debate within the community regarding the use of gradient echo or spin echo based acquisition methods. Phase regression technique shows potential as a useful method in low signal-to-noise ratio studies such as high-resolution fMRI.
Article
Chemistry, Analytical
Alexander Kasperkiewicz, Sofia Lendor, Janusz Pawliszyn
Summary: The study investigated the relative matrix effects between coated blade spray (CBS) and liquid chromatographic separation approaches in multiresidue pesticide analysis in strawberry samples. The findings showed that acceptable slope relative standard deviations were observed under both CBS-MS/MS and LC-MS/MS approaches, indicating the elimination of relative matrix effects and no compromise with matrix effects when using the direct-to-MS approach. Additionally, the resistance of the methods to excipients present in pesticide formulations was highlighted.
Letter
Clinical Neurology
James E. Siegler, Steven Galetta
Summary: A study was conducted on patients with autosomal recessive limb-girdle muscular dystrophy type 12 (LGMDR12), and it was found that they did not have significant clinical worsening over a 2-year period. However, patients with LGMDR12 and intermediate-stage fatty replacement of muscle tissue experienced a significant worsening in Biodex Isometric Dynamometry, even after 1 year. This quantitative tool may be useful for monitoring clinical progression and response to targeted treatments.
Letter
Clinical Neurology
Tomoyuki Kawada
Summary: De Wel et al. conducted a prospective study to evaluate the prognosis in patients with LGMDR12. Muscle strength decreased significantly in the right quadricep muscles after 1 year, as shown by Biodex(R) isometric dynamometry. However, measures such as 6-minute walk distance, 10-meter walk test, and Medical Research Council sum scores did not show significant changes, even after 2 years. Thigh muscle proton density fat fraction imaging was identified as a sensitive indicator for tracking progressive muscle fat replacement.
Article
Clinical Neurology
Steven E. Galetta, Aravind Ganesh, Ariane Lewis, James E. Siegler III
Summary: This prospective study investigated 24 patients with LGMDR12 and found that patients with intermediate-stage fatty replacement showed significant worsening in Biodex Isometric Dynamometry after 1 year, while their clinical assessments did not show apparent deterioration over a 2-year period. The researchers suggest that this quantitative tool can be useful in monitoring disease progression and treatment response in LGMDR12.
Article
Neuroimaging
Katherine E. Lawrence, Leila Nabulsi, Vigneshwaran Santhalingam, Zvart Abaryan, Julio E. Villalon-Reina, Talia M. Nir, Iyad Ba Gari, Alyssa H. Zhu, Elizabeth Haddad, Alexandra M. Muir, Emily Laltoo, Neda Jahanshad, Paul M. Thompson
Summary: The study utilized dMRI to assess white matter microstructure in 15,628 adults aged 45-80 years old, finding significant effects of age and sex. The advanced dMRI models TDF and NODDI were more sensitive in detecting these effects, providing an important foundation for research on healthy and diseased brain aging.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Bram De Wel, Kristl G. Claeys
Summary: We appreciate Professor Kawada's comments on our article. The study involved three evaluations of all participants at strict 1-year intervals, without any missed visits or missing data. The researchers also ensured phenotypic homogeneity by excluding patients with isolated hyperCKemia and defining disease onset based on clinical symptoms of LGMDR12.
Article
Clinical Neurology
S. Grahl, M. Bussas, B. Wiestler, P. Eichinger, C. Gaser, J. Kirschke, C. Zimmer, A. Berthele, B. Hemmer, M. Muehlau
Summary: This study compared the effects of Fingolimod and Natalizumab in treating relapsing-remitting multiple sclerosis, finding that Fingolimod treatment led to more new white matter lesions but lower overall brain atrophy. The results support the notion that Fingolimod has stronger neuroprotective properties compared to Natalizumab.
Article
Sport Sciences
David Rodriguez-Rosell, Eduardo Saez de Villarreal, Ricardo Mora-Custodio, Jose Antonio Asian-Clemente, Beatriz Bachero-Mena, Irineu Loturco, Fernando Pareja-Blanco
Summary: The study compared the effects of different loading conditions on sprint performance and jump ability during resisted sprint training. The findings suggest that resisted sprint training with a moderate load (40% of body mass) may have a positive effect on both unresisted and resisted sprint performance.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Neurosciences
Claudio Cordani, Paolo Preziosa, Roberto Gatti, Carlotta Castellani, Massimo Filippi, Maria Assunta Rocca
Summary: Brain MRI studies have revealed differences in brain structure and function between high-level athletes and nonathletes, suggesting that intense training leads to optimization of brain networks involved in motor activities, including interlimb coordination tasks.
HUMAN BRAIN MAPPING
(2022)
Article
Nutrition & Dietetics
Naoki Ota, Hiroto Ito, Kazushige Goto
Summary: Assessment of breath acetone level may be an alternative method to evaluate changes in fat metabolism. This study found that insufficient carbohydrate intake after exercise can increase breath acetone level, but there was no significant difference in breath acetone level the following morning.
Article
Pharmacology & Pharmacy
Lingling Yang, Xiaojuan Su, Fangfang Lu, Rong Zong, Shuqin Ding, Jing Liu, Gidion Wilson, Liuyan Li, Youyue Yang, Weibiao Wang, Xiaoying Wang, Jianyu Chen, Xueqin Ma
Summary: Bai-Mi-Decoction (BMD), a traditional Chinese medicine formula, has been shown to have protective effects on ischemic stroke (IS). This study aimed to investigate the underlying mechanisms of BMD using pharmacodynamic and metabolomic methods. The results demonstrated that BMD exerted significant neuroprotective effects on rats with middle cerebral artery occlusion-reperfusion injury, potentially through regulating amino acid and glycerophospholipid metabolisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lynn Daboul, Carly M. O'Donnell, Quy Cao, Moein Amin, Paulo Rodrigues, John Derbyshire, Christina Azevedo, Amit Bar-Or, Eduardo Caverzasi, Peter Calabresi, Bruce A. C. Cree, Leorah Freeman, Roland G. Henry, Erin E. Longbrake, Kunio Nakamura, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Rohini D. Samudralwar, Suradech Suthiphosuwan, Matthew K. Schindler, Elias S. Sotirchos, Nancy L. Sicotte, Andrew J. Solomon, Russell T. Shinohara, Daniel S. Reich, Daniel Ontaneda, Pascal Sati
Summary: This study assesses the impact of gadolinium-based contrast agent (GBCA) on the evaluation of central vein sign (CVS) and the diagnostic performance of CVS for multiple sclerosis (MS). The results show that the use of GBCA enhances the detection rate of CVS on FLAIR* images and improves the sensitivity of CVS for the diagnosis of MS.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Clinical Neurology
Kunio Nakamura, Marisa P. McGinley, Stephen E. Jones, Mark J. Lowe, Jeffrey A. Cohen, Paul M. Ruggieri, Daniel Ontaneda
Summary: The clinical correlation between gadolinium-based contrast agents (GBCAs) and multiple sclerosis (MS) has not been well studied. This study investigated the association between the cumulative number of GBCA exposures and self-reported disability and performance measures in MS patients. The results showed weak associations between contrast ratio in globus pallidus and the measures, but the associations disappeared after adjusting for covariates. Linear GBCA administrations were associated with better outcomes in terms of PDDS, while macrocyclic GBCA administrations were associated with better outcomes in terms of MDT. No detrimental effects were observed between GBCA exposure and disability or performance measures.
JOURNAL OF NEUROIMAGING
(2023)
Editorial Material
Clinical Neurology
J. Nicholas Brenton, Laura Piccio
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sibaji Gaj, Brendan L. Eck, Dongxing Xie, Richard Lartey, Charlotte Lo, William Zaylor, Mingrui Yang, Kunio Nakamura, Carl S. Winalski, Kurt P. Spindler, Xiaojuan Li
Summary: Fast and accurate segmentation of thigh muscles from MRI is crucial for quantifying thigh muscle morphology and composition. A new deep learning-based segmentation model was developed for automated and reproducible cross-sectional area (CSA) and fat fraction (FF) quantification. The model was tested on patients who underwent anterior cruciate ligament reconstructions 10 years ago.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Brian Florenzo, J. Nicholas Brenton
Summary: Studies compared the clinical phenotypes and neuroimaging of children with MOGAD and multiple sclerosis, and found differences in demographics, socioeconomic factors, and paraclinical features between the two disorders. MOGAD patients had younger age, lower body mass index percentiles, and higher rates of infectious prodrome compared to multiple sclerosis. MOGAD patients were also more likely to have mothers with higher education levels, lower rates of prior Epstein-Barr virus infection, and fewer oligoclonal bands in the cerebrospinal fluid.
JOURNAL OF CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Ebtesam Alshehri, Jeffrey A. Cohen, Daniel Ontaneda, Kunio Nakamura, Scott Husak, Thomas E. Love, Robert J. Fox, Farren B. S. Briggs, Devon S. Conway
Summary: Smoking is associated with an increased risk of multiple sclerosis (MS) and disability worsening. This study quantified the impact of smoking on processing speed and brain volume in MS patients and explored the longitudinal relationship between smoking and changes in processing speed. The results showed that smoking was associated with lower processing speed and reduced gray matter fraction. These observations support the importance of smoking cessation counseling in MS management.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Katrina Peariso, Ravindra S. Arya, Tracy Glauser, Nicholas Abend, Cristina Barcia Aguilar, Marta L. Amengual-Gual, Anne Anderson, Brian Appavu, J. Nicholas E. Brenton, Jessica Carpenter, Kevin D. Chapman, Justice Clark, William Gaillard, Marina Gainza-Lein, Joshua Goldstein, Howard M. Goodkin, Zachary S. Grinspan, Rejean Guerriero, Paul Horn, Linda A. Huh, Robert H. Kahoud, Sarah Kelley, Eric Kossoff, Kush Kapur, Yi-Chen Lai, B. Oyinkan A. Marquis, Tiffani McDonough, Mohamad Mikati, Lindsey P. Morgan, Edward T. Novotny, Adam Ostendorf, Eric Payne, Juan Piantino, James E. Riviello, Tristan C. Sands, Carl Stafstrom, Robert Tasker, Dmitry S. Tchapyjnikov, Alejandra Vasquez, Mark Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper, PSERG
Summary: This study aimed to identify patient-specific factors associated with the development of refractory convulsive status epilepticus (RSE) in children treated in emergency care. The study found that a family history of seizures and the use of rectal diazepam were associated with a decreased likelihood of RSE.
Editorial Material
Clinical Neurology
James Nicholas Brenton
SEMINARS IN PEDIATRIC NEUROLOGY
(2023)
Review
Clinical Neurology
Darina Dinov, James Nicholas Brenton
Summary: Pediatric multiple sclerosis (MS) accounts for a small percentage of all MS cases, but the environmental factors that contribute to the risk are similar to adult-onset MS. Children with MS are in closer proximity to the disease onset and have fewer confounding environmental factors. This article examines the environmental risk determinants of pediatric MS and reviews how these factors may impact the disease's evolution.
SEMINARS IN PEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Tiffany Grezmak, John W. Lace, Kunio Nakamura, Daniel Ontaneda, Rachel Galioto
Summary: The prevalence of naming impairment in patients with multiple sclerosis (pwMS) was examined using a measure of confrontation naming, and correlates with neuroimaging were identified. The results showed that naming difficulties are common in pwMS and are more strongly associated with neuroimaging of MS brain pathology.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Unsong Oh, Emma Woolbright, Diana Lehner-Gulotta, Rachael Coleman, Mark Conaway, Myla D. Goldman, J. Nicholas Brenton
Summary: This study investigated the impact of ketogenic diets on the biomarker of neuroaxonal injury, neurofilament light chain (NfL), in patients with multiple sclerosis (MS). The results showed that ketogenic diets did not worsen the biomarkers of neurodegeneration in MS patients and NfL levels remained stable and low during the diet intervention. Furthermore, patients with higher levels of ketosis experienced a greater reduction in NfL levels during the ketogenic diet.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Po-Hao Chen, Kunio Nakamura, Nancy Obuchowski, Michael Chih-Yang Juan, Shaoxiong Zhang, Scott D. Flamm, Milind Y. Desai, Torey Hovest, Thad Meese, Paul Schoenhagen
Summary: This study aimed to determine if cross-sectional Hounsfield Unit (HU) variability can reliably identify patients with aortic dissections, including intramural hematomas (IMH). The results showed that the maximum difference in HUs can be a strong predictor of aortic dissection in dedicated ECG-gated aorta scans.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Clinical Neurology
Riana L. Schleicher, Pongpat Vorasayan, Megan E. McCabe, Matthew B. Bevers, Thomas P. Davis, John H. Griffin, Archana Hinduja, Ashutosh P. Jadhav, Jin-Moo Lee, Robert N. Sawyer Jr, Berislav Zlokovic, Kevin N. Sheth, Janel K. Fedler, Patrick Lyden, W. Taylor Kimberly
Summary: Cerebral edema is a common complication of acute ischemic stroke, and understanding its time course and imaging markers is important for patient management. In this study, the researchers examined the time course of edema and the association between net water uptake (NWU) and traditional markers of edema. The results showed that NWU provided distinct information and could be a useful marker in future trials targeting cerebral edema.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Marta Amengual-Gual, Ivan Sanchez Fernandez, Alejandra Vasquez, Nicholas S. Abend, Anne Anderson, Ravindra Arya, Cristina Barcia Aguilar, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William D. Gaillard, Tracy A. Glauser, Joshua L. Goldstein, Howard P. Goodkin, Yi-Chen Lai, Mohamad A. Mikati, Lindsey A. Morgan, Edward J. Novotny, Adam P. Ostendorfr, Eric T. Payne, Katrina Peariso, Juan Piantino, Latania Reece, James J. Riviello, Kumar Sannagowdara, Theodore Sheehan, Robert C. Tasker, Dmitry Tchapyjnikov, Alexis A. Topjianv, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper
Summary: Delayed treatment in status epilepticus is associated with increased resistance, morbidity, and mortality. This study examines the prehospital management pathway and timeliness of Emergency Medical Services in children with refractory convulsive status epilepticus. The results indicate that a substantial number of patients did not receive any anti-seizure medication before arriving at the hospital, and patients with a history of seizures were more likely to receive prehospital treatment.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Neurosciences
Catherine Stratton, Areti Vassilopoulos, J. Nicholas Brenton, Kirsten Potter, Wendy Vargas, Heather Rumm, Andrea Bartels, Mary Bailey, Charles Odonkor, Sharon Stoll, E. William T. Zempsky, E. Ann Yeh, Naila Makhani
Summary: This study aimed to develop an interdisciplinary interim guideline for the assessment and management of pain in children with MS. Literature on pain in children with MS is scarce, and further studies are needed to assess the implementation of these guidelines in clinical settings.
FRONTIERS IN NEUROSCIENCE
(2023)