The EDSS-Plus, an improved endpoint for disability progression in secondary progressive multiple sclerosis

Individual and Composite Study Endpoints: Separating the Wheat from the Chaff

(2014) Robert Goldberg et al.   AMERICAN JOURNAL OF MEDICINE

Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis

(2014) Sandra Meyer-Moock et al.   BMC Neurology

Composite end points to assess delay of disability progression by MS treatments

(2014) J Zhang et al.   Multiple Sclerosis Journal

Addressing the regulatory and scientific challenges in multiple sclerosis – a statement from the EU regulators

(2014) Pavel Balabanov et al.   Multiple Sclerosis Journal

Anomalous functional language lateralization in semantic variant PPA

(2014) Z. A. Miller et al.   NEUROLOGY

Defining the clinical course of multiple sclerosis: The 2013 revisions

(2014) F. D. Lublin et al.   NEUROLOGY

Multiple Sclerosis Outcome Assessments Consortium: Genesis and initial project plan

(2013) Richard A Rudick et al.   Multiple Sclerosis Journal

Clinically meaningful performance benchmarks in MS: Timed 25-Foot Walk and the real world

(2013) M. D. Goldman et al.   NEUROLOGY

Impact of Natalizumab on Ambulatory Improvement in Secondary Progressive and Disabled Relapsing-Remitting Multiple Sclerosis

(2013) Diego Cadavid et al.   PLoS One

Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects

(2012) Jeffrey A Cohen et al.   LANCET NEUROLOGY

Comparison of Disease Activity in SPMS and PPMS in the Context of Multicenter Clinical Trials

(2012) Rotem Orbach et al.   PLoS One

Challenges to clinical trials in multiple sclerosis: outcome measures in the era of disease-modifying drugs

(2011) Megan Hyland et al.   CURRENT OPINION IN NEUROLOGY

A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS

(2011) M. S. Freedman et al.   NEUROLOGY

Progression on the Multiple Sclerosis Functional Composite in multiple sclerosis: what is the optimal cut-off for the three components?

(2010) LVAE Bosma et al.   Multiple Sclerosis Journal

The search for responsive clinical endpoints in primary progressive multiple sclerosis

(2009) LVAE Bosma et al.   Multiple Sclerosis Journal

Assessing disability progression with the Multiple Sclerosis Functional Composite

(2009) RA Rudick et al.   Multiple Sclerosis Journal

Disability as an outcome in MS clinical trials

(2008) G. C. Ebers et al.   NEUROLOGY