Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation

Cyclic-di-GMP Induces STING-Dependent ILC2 to ILC1 Shift During Innate Type 2 Lung Inflammation

(2021) Kellen J. Cavagnero et al.   Frontiers in Immunology

IRG1/Itaconate Activates Nrf2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

(2020) Zhongjie Yi et al.   HEPATOLOGY

Pyruvate Kinase M2 in lung APCs regulates Alternaria-induced airway inflammation

(2020) Anil Kumar Jaiswal et al.   IMMUNOBIOLOGY

Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

(2020) Kaitlyn A Sun et al.   eLife

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2

(2020) Haoyu Song et al.   EBioMedicine

Itaconate controls the severity of pulmonary fibrosis

(2020) Patricia P. Ogger et al.   Science Immunology

4-Octyl itaconate (4-OI) attenuates lipopolysaccharide-induced acute lung injury by suppressing PI3K/Akt/NF-κB signaling pathways in mice

(2020) Yan Xin et al.   Experimental and Therapeutic Medicine

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation

(2020) Yang Li et al.   Drug Design Development and Therapy

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

(2019) Brian P. Daniels et al.   IMMUNITY

The Global Initiative for Asthma (GINA): 25 years later

(2019) Louis-Philippe Boulet et al.   EUROPEAN RESPIRATORY JOURNAL

Metabolic Control of Dendritic Cell Functions: Digesting Information

(2019) Stefanie K. Wculek et al.   Frontiers in Immunology

The Immunomodulatory Potential of the Metabolite Itaconate

(2019) Alexander Hooftman et al.   TRENDS IN IMMUNOLOGY

Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection

(2018) Sharmila Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells

(2018) Marine Oberkampf et al.   Nature Communications

Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue

(2018) Henrike Fleige et al.   Cell Reports

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells

(2018) Kenneth P. Hough et al.   Redox Biology

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

(2018) David Olagnier et al.   Nature Communications

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

(2018) Sulayman Benmerzoug et al.   Nature Communications

IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species

(2017) Xing Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Low-density lipoprotein receptor–related protein 1 attenuates house dust mite–induced eosinophilic airway inflammation by suppressing dendritic cell–mediated adaptive immune responses

(2017) Amarjit Mishra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

(2017) Charles Sinclair et al.   SCIENCE

Glucose represses dendritic cell-induced T cell responses

(2017) Simon J. Lawless et al.   Nature Communications

Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma

(2017) Amarjit Mishra   Journal of Immunology Research

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species

(2016) Ke Ren et al.   JOURNAL OF VIROLOGY

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

(2016) Aravind Tallam et al.   PLoS One

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

(2015) Emma S. Chambers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase

(2015) Amarjit Mishra et al.   Nature Communications

Platelets from Asthmatic Individuals Show Less Reliance on Glycolysis

(2015) Weiling Xu et al.   PLoS One

Mitochondrial Structural Changes and Dysfunction Are Associated with Experimental Allergic Asthma

(2014) U. Mabalirajan et al.   JOURNAL OF IMMUNOLOGY

Bacterial itaconate degradation promotes pathogenicity

(2014) Jahminy Sasikaran et al.   Nature Chemical Biology

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma

(2014) JUN PAN et al.   ONCOLOGY REPORTS

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

(2014) Benjamin J. Green et al.   PLoS One

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species

(2013) Yingke Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of the Tumor Suppressor Tuberous Sclerosis Complex 1 in Dendritic Cell Activation of CD4 T Cells by Promoting MHC Class II Expression via IRF4 and CIITA

(2013) H. Pan et al.   JOURNAL OF IMMUNOLOGY

Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation

(2013) D L Clarke et al.   Mucosal Immunology

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

(2013) Hyelim Cho et al.   NATURE MEDICINE

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asthma heterogeneity and severity—why is comprehensive phenotyping important?

(2013) Wendy C Moore et al.   Lancet Respiratory Medicine

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Interleukin-10 Alters Effector Functions of Multiple Genes Induced by Borrelia burgdorferi in Macrophages To Regulate Lyme Disease Inflammation

(2011) Aarti Gautam et al.   INFECTION AND IMMUNITY

Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-  Activity in Dendritic Cells

(2011) A. Legutko et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Aspergillus fumigatus regulates mite allergen-pulsed dendritic cells in the development of asthma

(2010) S. Fukahori et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

(2010) Annette T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD11c depletion severely disrupts Th2 induction and development in vivo

(2010) Alexander T. Phythian-Adams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biology of Lung Dendritic Cells at the Origin of Asthma

(2009) Bart N. Lambrecht et al.   IMMUNITY

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

The Proinflammatory Cytokine-Induced IRG1 Protein Associates with Mitochondria

(2008) Daniel Degrandi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH