Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations

Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt

(2022) Vadivel Mani et al.   Bioinformation

Cinnamaldehyde mitigates placental vascular dysfunction of gestational diabetes and protects from the associated fetal hypoxia by modulating placental angiogenesis, metabolic activity and oxidative stress

(2021) Ahmed Hosni et al.   PHARMACOLOGICAL RESEARCH

Plant-Derived Trans-β-Caryophyllene Boosts Glucose Metabolism and ATP Synthesis in Skeletal Muscle Cells through Cannabinoid Type 2 Receptor Stimulation

(2021) Federica Geddo et al.   Nutrients

Cinnamaldehyde Improves Metabolic Functions in Streptozotocin-Induced Diabetic Mice by Regulating Gut Microbiota

(2021) Honglei Zhao et al.   Drug Design Development and Therapy

Effect of Nano-eugenol and Aerobic Exercise Against the Streptozotocin Toxicity and Inflammatory Mediators P38-MAPK, NPY, and A-Rα2A in the Dorsal Root Ganglia of Diabetic Rats

(2021) Abbas Shareghi Boroujeni et al.   Iranian Journal of Toxicology

Cinnamaldehyde Ameliorates Vascular Dysfunction in Diabetic Mice by Activating Nrf2

(2020) Peijian Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells

(2020) Heng Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

β-Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice

(2019) Dalia Samanta Aguilar-Ávila et al.   JOURNAL OF MEDICINAL FOOD

Encapsulation of cinnamon oil in whey protein counteracts the disturbances in biochemical parameters, gene expression, and histological picture of the liver and pancreas of diabetic rats

(2019) Kamal A. A. Mohammed et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

(2018) Mir Hussain Nawaz et al.   BIOSCIENCE REPORTS

Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat-diet/streptozotocin-induced diabetic rat

(2018) Bahaa Al-Trad et al.   LIFE SCIENCES

Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: The role of CB2 and PPAR-γ receptors

(2018) Dareen A. Youssef et al.   BIOMEDICINE & PHARMACOTHERAPY

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

(2017) Wei Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

β-Caryophyllene, a natural sesquiterpene lactone attenuates hyperglycemia mediated oxidative and inflammatory stress in experimental diabetic rats

(2016) Rafeek Hidhayath Basha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Eugenol ameliorates renal damage in streptozotocin-induced diabetic rats

(2016) Mayuresh Sudamrao Garud et al.   FLAVOUR AND FRAGRANCE JOURNAL

Essential oil from Cinnamomum cassia bark through hydrodistillation and advanced microwave assisted hydrodistillation

(2016) Nitthiyah Jeyaratnam et al.   INDUSTRIAL CROPS AND PRODUCTS

Neurorestorative effects of eugenol, a spice bioactive: Evidence in cell model and its efficacy as an intervention molecule to abrogate brain oxidative dysfunctions in the streptozotocin diabetic rat

(2016) Sathya N. Prasad et al.   NEUROCHEMISTRY INTERNATIONAL

Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde

(2016) Akshay Jawale et al.   PHYTOMEDICINE

My Way: Noncanonical Biosynthesis Pathways for Plant Volatiles

(2016) Pulu Sun et al.   TRENDS IN PLANT SCIENCE

Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR

(2015) Juan-E Li et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Effects of piragliatin, a glucokinase activator, on fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus

(2015) Jianguo Zhi et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

(2015) Susana Camacho et al.   Scientific Reports

β-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats

(2014) Rafeek Hidhayath Basha et al.   ACTA HISTOCHEMICA

Effects of eugenol on hepatic glucose production and AMPK signaling pathway in hepatocytes and C57BL/6J mice

(2014) Kyong Ju Jeong et al.   FITOTERAPIA

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

(2013) Cecilia Marini et al.   CELL CYCLE

Pharmacokinetic study of cinnamaldehyde in rats by GC–MS after oral and intravenous administration

(2013) Hang Zhao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats

(2013) Subramani Srinivasan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats

(2013) Kais Mnafgui et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil

(2013) Chen-Tien Chang et al.   Botanical Studies

Insights into Mechanism of Glucokinase Activation

(2012) Shenping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Piragliatin—First Glucokinase Activator Studied in Type 2 Diabetic Patients

(2012) Ramakanth Sarabu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucokinase Activators for Diabetes Therapy: May 2010 status report

(2011) F. M. Matschinsky et al.   DIABETES CARE

Cinnamaldehyde protects from the hypertension associated with diabetes

(2011) Hany M. El-Bassossy et al.   FOOD AND CHEMICAL TOXICOLOGY

Structural insight into substrate specificity of human intestinal maltase-glucoamylase

(2011) Limei Ren et al.   Protein & Cell

Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats

(2010) Prachi Anand et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice

(2010) Hua Ping et al.   FOOD AND CHEMICAL TOXICOLOGY

Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study

(2010) Riccardo C. Bonadonna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cinnamon (Cinnamomum Species)

(2009) Donald G. Barceloux   DM DISEASE-A-MONTH

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Chemical Composition of Cinnamomum cassia Leaf Oils and Suppression Effect of Cinnamyl Alcohol on Nitric Oxide Synthase

(2009) Hoi-Seon Lee   Journal of the Korean Society for Applied Biological Chemistry

Ameliorative Effect of the Cinnamon Oil fromCinnamomum zeylanicumupon Early Stage Diabetic Nephropathy

(2009) Awanish Mishra et al.   PLANTA MEDICA

Correlation Between Chemical Composition and Antifungal Activity of the Essential Oils of EightCinnamomum. Species

(2008) Ibrahim bin Jantan et al.   PHARMACEUTICAL BIOLOGY

In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits

(2007) Tülay Bakırel et al.   JOURNAL OF ETHNOPHARMACOLOGY