Article
Biochemistry & Molecular Biology
Thiago da Rosa Lima, Fabricio Azevedo Voltarelli, Lorena Silva Freire, Franciely Alves da Silva, Paula Caroline de Almeida, Eudes Thiago Pereira Avila, Suelem Aparecida de Franca, Mayara Peron Pereira, Amilcar Sabino Damazo, James Wilfred Navalta, Carlos Alexandre Fett, Nair Honda Kawashita
Summary: This study found that combining a high-fat diet with a fructose drink resulted in metabolic and hormonal changes more similar to human obesity. The high-fat diet group showed higher body weight and other related indicators compared to the control group.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Changlin Zhen, Xunxun Wu, Jing Zhang, Dan Liu, Guoli Li, Yongbo Yan, Xiuzhen He, Jiawei Miao, Hongxia Song, Yifan Yan, Yonghui Zhang
Summary: The study found that Ganoderma lucidum polysaccharides (GLPs) can alleviate cardiac hypertrophy and fibrosis by inhibiting the expression of key genes, and attenuate pressure overload-induced pathological cardiac hypertrophy by activating PPAR?. This study provides important theoretical support for the potential use of GLPs in treating pathological myocardial hypertrophy and heart failure.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Tong Wu, Qinhui Liu, Yanping Li, Hong Li, Lei Chen, Xuping Yang, Qin Tang, Shiyun Pu, Jiangying Kuang, Rui Li, Ya Huang, Jinhang Zhang, Zijing Zhang, Jian Zhou, Cuiyuan Huang, Guorong Zhang, Yingnan Zhao, Min Zou, Wei Jiang, Li Mo, Jinhan He
Summary: Liver-specific overexpression of Manf promotes browning of white adipocytes and protects against obesity, insulin resistance, and hepatic steatosis. Mechanistically, Manf can directly promote browning of white adipocytes via the p38 MAPK pathway. Moreover, circulating levels of Manf are positively correlated with BMI in humans.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yuansheng Liu, Qian Zhang, Lei Yang, Wencong Tian, Yinan Yang, Yuhang Xie, Jing Li, Liang Yang, Yang Gao, Yang Xu, Jie Liu, Yachen Wang, Jie Yan, Guoxun Li, Yanna Shen, Zhi Qi
Summary: Metformin attenuates cardiac hypertrophy via the HIF-1 alpha/PPAR-gamma signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Jinghua Bu, Minjie Zhang, Yang Wu, Nan Jiang, Yuli Guo, Xin He, Hui He, M. Vimalin Jeyalatha, Peter Sol Reinach, Zuguo Liu, Wei Li
Summary: High-fat diet-induced declines in PPAR-gamma expression and activation of MAPK and NF-kappa B signaling pathways may lead to meibomian gland inflammation and dysfunction in mice, characterized by lipid accumulation, inflammatory cell infiltration, apoptosis, and mitochondria damage. Treatment involving dietary shifts and medication administration can alleviate this inflammation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yong Zhang, Jie Xu, Di Zhou, Tingting Ye, Puqing Zhou, Zuofeng Liu, Xinyuan Liu, Zinan Wang, Tianmiao Hua, Zhenghao Zhang, Qingyan Sun
Summary: This study demonstrates that swimming exercise can improve lipid metabolism in insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) through modulation of PPAR gamma signaling in the liver of mice.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wen Meng, Ting Xiao, Xiuci Liang, Jie Wen, Xinyi Peng, Jing Wang, Yi Zou, Jiahao Liu, Christie Bialowas, Hairong Luo, Yacheng Zhang, Bilian Liu, Jingjing Zhang, Fang Hu, Meilian Liu, Lily Q. Dong, Zhiguang Zhou, Feng Liu, Juli Bai
Summary: The study identifies miR-182-5p as a crucial antiobesity molecule that promotes beige fat thermogenesis by enhancing the interaction between adipocytes and macrophages. It functions by suppressing Nr1d1 to promote FGF21 expression in adipocytes, leading to acetylcholine release in macrophages and subsequent activation of thermogenic gene expression in adipocytes.
Article
Biochemistry & Molecular Biology
Rosaria Scandiffio, Sara Bonzano, Erika Cottone, Sujata Shrestha, Simone Bossi, Silvia De Marchis, Massimo E. Maffei, Patrizia Bovolin
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease without approved pharmacological therapy. The study investigated the effects of (E)-beta-caryophyllene (BCP), a phytocannabinoid, on HepG2 steatotic hepatocytes. BCP was found to decrease lipid accumulation and change the lipid profile in steatotic conditions by reducing saturated fatty acids. The action of BCP was mediated by CB2 cannabinoid receptor, peroxisome proliferator-activated receptor alpha (PPAR alpha), and gamma (PPAR gamma). The results suggest potential applications of BCP in the treatment of NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaodong Wu, Ting Zhang, Ping Lyu, Mengli Chen, Gehui Ni, Huiling Cheng, Guie Xu, Xinli Li, Lijun Wang, Hongcai Shang
Summary: QLQX attenuates diabetic cardiomyopathy by activating PPAR gamma, reducing hyperglycemia-induced cardiomyocyte apoptosis and protecting mice from cardiac dysfunction and pathological remodeling caused by diabetes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Food Science & Technology
Fangbo Zhang, Yu Li, Weijuan Xin, Lifang Wang, Yi Zhang, He Xu, Hongjie Wang, Haiyu Zhao, Hongjun Yang, Nan Si, Baolin Bian
Summary: The combination of Gyps and Caps effectively ameliorates high-fat-diet-induced hyperlipidemia and alleviates liver damage. This research provides an experimental basis for the advanced study and clinical application of Gyps/Caps combination in treating NAFLD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Dushyant Kshatriya, Lihong Hao, Nicholas T. Bello
Summary: This study found that raspberry ketone has a dose-dependent metabolic signature in white adipose tissue of mice, which is associated with weight control and loss of righting reflex. Raspberry ketone can regulate gene expression related to weight control and metabolic effects in adipose tissue.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Jibran A. Wali, Duan Ni, Harrison J. W. Facey, Tim Dodgson, Tamara J. Pulpitel, Alistair M. Senior, David Raubenheimer, Laurence Macia, Stephen J. Simpson
Summary: This study investigates the metabolic effects of sugars and fat, specifically the interaction between dietary fat and the main monosaccharides, fructose and glucose, on body composition and metabolic health. The results show that a 50:50 mixture of fructose and glucose, similar to high-fructose corn syrup, consumed in low and medium dietary fat content, is more obesogenic and metabolically adverse than when either monosaccharide is consumed alone. The effects of dietary sugar composition become less pronounced with increasing dietary fat content, and higher fat intake is more harmful for glucose tolerance and insulin sensitivity regardless of the sugar mix consumed.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Man-Jing Jiang, Li Li, Wan-Fang Huang, Jian Su, Yao-Hua Li, Xiao-Sheng Qu, Lan-Lan Fan
Summary: Rubus chingii var. suavissimus or Rubus suavissimus, a sweet plant in southwest China, has potential in improving obesity and hyperlipidemia. Studies showed that it can alleviate lipid metabolism disorder by modulating the PPARs/SREBP pathway in Syrian golden hamsters.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Fatma H. Rizk, Nema A. Soliman, Nehal A. Heabah, Muhammad T. Abdel Ghafar, Shimaa H. El-Attar, Amira Elsaadany
Summary: This study investigated the potential neuroprotective effects of fenofibrate on cognitive dysfunction induced by a high-fat, high-fructose diet and found that irisin and heat shock protein 70 play important roles in these effects.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fatma H. Rizk, Nema A. Soliman, Nehal A. Heabah, Muhammad T. Abdel Ghafar, Shimaa H. El-Attar, Amira Elsaadany
Summary: This study investigated the neuroprotective effects of fenofibrate on cognitive dysfunction induced by a high-fat, high-fructose diet. Fenofibrate restored hippocampus histological characteristics, improved cognitive deficit, reduced body weight gain, and had hypolipidemic, antioxidant, and anti-inflammatory effects. It also prevented hypoxia and enhanced synaptic plasticity. The involvement of irisin, HSP70, and the PGC-1 alpha/irisin/brain-derived neurotrophic factor pathway were observed. Fenofibrate may be a potential medication for treating neurodegenerative disorders induced by a high-fat, high-fructose diet.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Hoda M. S. Ahmed, Samar G. Mohamed, Wael S. Ibrahim, Asmaa M. Rezk, Amr A. A. Mahmoud, Mona F. Mahmoud, Islam A. A. E. -H. Ibrahim
Summary: This study aimed to investigate the acute and chronic effects of carvedilol on insulin resistance in high-fructose, high-fat diet fed mice and the implication of the beta-arrestin2 pathway. The results showed that carvedilol acutely reduced fasting blood glucose levels and chronic administration significantly ameliorated insulin resistance and dyslipidemia in the mice. The insulin sensitizing effects of carvedilol are highly correlated with the up regulation of the beta-arrestin2 pathway.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mona F. Mahmoud, Mohamed Nabil, Rehab A. Hasan, Assem M. El-Shazly, Mohamed A. El-Ansari, Mansour Sobeh
Summary: This study found that pentagalloyl glucose (PGG) has a protective effect against gastric ulcers, possibly by increasing mucus production, scavenging free radicals, reducing inflammation, and attenuating the NO/NOS signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Mahmoud H. Elbatreek, Ismail Mahdi, Wafae Ouchari, Mona F. Mahmoud, Mansour Sobeh
Summary: Pinocembrin is a major flavonoid found in plants, fungi, and hive products like honey and propolis. It has been shown through in vitro and preclinical studies to have antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective, and anticancer activities. This comprehensive review discusses pinocembrin's mechanisms of action, bioavailability, toxicity, and clinical investigations. With a wide therapeutic window, pinocembrin shows promise as a drug candidate for various clinical applications, and further research is recommended to optimize its pharmacokinetic and pharmacodynamic properties for better delivery and therapeutic advances.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Shaimaa S. El-Sayed, Samar Rezq, Amira Ebrahim Alsemeh, Mona F. Mahmoud
Summary: This study suggests that the modulation of autophagy via I1R activation plays a role in the cardiac beneficial effects of moxonidine in metabolic syndrome.
Article
Biochemistry & Molecular Biology
Nora Tawfeek, Eman Fikry, Ismail Mahdi, Melvin Adhiambo Ochieng, Widad Ben Bakrim, Noamane Taarji, Mona F. F. Mahmoud, Mansour Sobeh
Summary: In this study, the phytochemical profile of Cupressus arizonica Greene leaf extracts was analyzed, and it was found that these extracts contained various compounds with antioxidant, anti-aging, and antibacterial activities. The aqueous extract showed significant antioxidant potential and inhibited enzymes related to skin remodeling and aging. It also suppressed biofilm formation and decreased motilities of a common skin pathogenic bacteria. Therefore, C. arizonica leaves can be considered as a promising candidate for skincare application.
Article
Medicine, Research & Experimental
Mona F. Mahmoud, Walied Abdo, Mohamed Nabil, Badreddine Drissi, Assem M. El-Shazly, Mohamed A. O. Abdelfattah, Mansour Sobeh
Summary: The butanol fraction of apple leaves (BLE) exhibited gastro-protective and healing effects against indomethacin-induced gastric ulcers in rats. It reduced oxidative stress, inflammatory cytokines, and COX-2 expression and increased mucoglycoproteins and HSP70 expression. These effects are likely due to the presence of phytoconstituents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ismail Mahdi, Nidal Fahsi, Hassan Annaz, Badreddine Drissi, Mustapha Barakate, Mona F. Mahmoud, Mansour Sobeh
Summary: In this study, the mineral composition, nutritional value, phytocontents, and dermatological properties of Thymus satureioides were assessed. The plant is rich in calcium, iron, amino acids, and polyphenols. It exhibits antioxidant and antibacterial activities, as well as significant effects on skin permeability.
Article
Food Science & Technology
Mona F. Mahmoud, Noura Ali, Ismail Mahdi, Omar Mouhtady, Islam Mostafa, Assem M. El-Shazly, Mohamed A. O. Abdelfattah, Rehab A. Hasan, Mansour Sobeh
Summary: Coriander essential oil, rich in linalool, gamma-terpinene and alpha-pinene, has been found to ameliorate dexamethasone-induced liver injury through Nrf2/HO-1 and antiapoptotic signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Plant Sciences
Mona F. Mahmoud, Nora Tawfeek, Noura Ali, Rehab A. Hasan, Mansour Sobeh, Assem M. El-Shazly
Summary: This study revealed that the leaf extract of Salix babylonica contains 84 secondary metabolites with antioxidant and anti-inflammatory properties. The results showed that the extract could mitigate dexamethasone-induced pancreatic damage by reducing oxidative stress and associated autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Mona F. Mahmoud, Rania A. Elrashidy, Heba Osama Mohammed, Badreddine Drissi, Ismail Mahdi, Mansour Sobeh
Summary: This study demonstrates the hepatoprotective potential of Thymus satureioides aerial parts extract and their essential oil against acrylamide-induced liver toxicity. The protective effects can be attributed to the diverse metabolites with pronounced antioxidant and anti-inflammatory activities present in Thymus satureioides.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Hassan Annaz, Shimaa Abdelaal, Dalia A. Mandour, Ismail Mahdi, Mona F. Mahmoud, Mansour Sobeh
Summary: This study characterized the phytocontents of Dys-phania ambrosioides seeds extract and investigated its effects on hind limb ischemia-reperfusion injury (HLIRI) in rats. The results showed that the extract prevented kidney and muscle damage, reduced oxidative stress and inflammation, and inhibited apoptosis. The study suggests that Dys-phania ambrosioides seeds have a protective effect on HLIRI through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pharmacology & Pharmacy
Eman Fikry, Ismail Mahdi, Ahmet Bugra Ortaakarsu, Nora Tawfeek, Melvin Adhiambo Ochieng, Widad Ben Bakrim, Mohamed A. O. Abdelfattah, Khaled W. Omari, Mona F. Mahmoud, Mansour Sobeh
Summary: This study investigated the phytochemical profile of an ethanol bark extract from Pseudobombax ellipticum and evaluated its antioxidant, antiaging, and antibacterial activities. The extract exhibited promising in vitro antioxidant activity, effectively inhibited key enzymes associated with skin aging, and showed inhibitory effects on biofilm production of Pseudomonas aeruginosa.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Afoua Mufti, Anouar Feriani, Wafae Ouchari, Yasmine M. Mandour, Nizar Tlili, Mohammed Auwal Ibrahim, Mona F. Mahmoud, Mansour Sobeh
Summary: In this study, the protective effect of Leonotis ocymifolia extract against cisplatin-induced nephrotoxicity was explored. The extract was found to have antioxidant properties and significantly improved renal injury markers. It also mitigated the oxidative stress and inflammation caused by cisplatin and showed stable binding to IL-6. The histopathological observations confirmed the nephroprotective effects of the extract.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Mahmoud H. Elbatreek, Ayman M. Fathi, Ismail Mahdi, Mohamed A. O. Abdelfattah, Mona F. Mahmoud, Mansour Sobeh
Summary: This study investigates the therapeutic potential of Thymus satureioides (TS) extract for tongue ulcers. The active ingredients in the extract were found to promote ulcer healing by inhibiting inflammation, apoptosis, and proteolysis. However, further studies are needed to confirm the effectiveness of specific constituents in treating oral ulcerations.
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Dalia I. Hamdan, Rasha A. Attia, Manal A. Nael, Mona F. Mahmoud, Assem M. El-Shazly
Summary: Citrus fruits are economically important due to their nutrition value, medicinal importance, and unique flavor. The oil extracted from the roots contains compounds such as aromadendrene, germacrene B, and limonene. Chemical analysis of the roots also revealed the presence of acridone alkaloids, coumarins, and flavonoids. Xanthyletin and citracridone I showed protective effects against cisplatin-induced nephrotoxicity and elevated levels of malondialdehyde and glutathione in renal and cardiac tissues.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
