The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

Hexokinase 2 is a determinant of neuroblastoma metastasis

(2016) Liat Edry Botzer et al.   BRITISH JOURNAL OF CANCER

Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth

(2016) Huanan Wang et al.   Cancer Cell International

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

(2016) Hong Lin et al.   ACS Medicinal Chemistry Letters

Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma

(2014) Grace Guzman et al.   DIGESTIVE DISEASES AND SCIENCES

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Hexokinase–mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes

(2013) Guillaume Calmettes et al.   JOURNAL OF GENERAL PHYSIOLOGY

Insights into Mechanism of Glucokinase Activation

(2012) Shenping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Magnesium Ion–Water Coordination and Exchange in Biomolecular Simulations

(2012) Olof Allnér et al.   Journal of Chemical Theory and Computation

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

How Conformational Dynamics of DNA Polymerase Select Correct Substrates: Experiments and Simulations

(2012) Serdal Kirmizialtin et al.   STRUCTURE

The active conformation of human glucokinase is not altered by allosteric activators

(2011) Pierre Petit et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enzymatic properties of the N- and C-terminal halves of human hexokinase II

(2011) Keun-Jae Ahn et al.   BMB Reports

Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

(2011) Scott John et al.   PLoS One

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism

(2010) Nataly Shulga et al.   CELL CYCLE

Crystal Structure of Hexokinase KlHxk1 ofKluyveromyces lactis

(2010) E. Bartholomeus Kuettner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

(2010) Andreas H. Ratje et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

High throughput methods of assessing protein stability and aggregation

(2008) Guillermo A. Senisterra et al.   Molecular BioSystems

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One

An all-atom structure-based potential for proteins: Bridging minimal models with all-atom empirical forcefields

(2008) Paul C. Whitford et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS