Role of Caryophyllane Sesquiterpenes in the Entourage Effect of Felina 32 Hemp Inflorescence Phytocomplex in Triple Negative MDA-MB-468 Breast Cancer Cells

Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization

(2021) Omer Anis et al.   MOLECULES

Cannabinoids in the landscape of cancer

(2021) Nagina Mangal et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview

(2021) Pradeep Kumar et al.   PHYTOTHERAPY RESEARCH

Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations

(2021) Lyndsey L. Anderson et al.   Scientific Reports

Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: an in Vitro and in Silico Study

(2020) Di Sotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cannabis sativa L. Inflorescences from Monoecious Cultivars Grown in Central Italy: An Untargeted Chemical Characterization from Early Flowering to Ripening

(2020) Cinzia Ingallina et al.   MOLECULES

β-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells

(2020) Natasha Irrera et al.   Cancers

Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention

(2020) Antonella Di Sotto et al.   Cells

Water Extract from Inflorescences of Industrial Hemp Futura 75 Variety as a Source of Anti-Inflammatory, Anti-Proliferative and Antimycotic Agents: Results from In Silico, In Vitro and Ex Vivo Studies

(2020) Giustino Orlando et al.   Antioxidants

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

(2020) Andrea M. Tomko et al.   Cancers

Antiarthritic Effects of a Root Extract from Harpagophytum procumbens DC: Novel Insights into the Molecular Mechanisms and Possible Bioactive Phytochemicals

(2020) Alessia Mariano et al.   Nutrients

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

(2020) Antonella Di Sotto et al.   Cancers

Chemosensitization of hepatocellular carcinoma cells to sorafenib by β-caryophyllene oxide-induced inhibition of ABC export pumps

(2019) Silvia Di Giacomo et al.   ARCHIVES OF TOXICOLOGY

The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain

(2019) Ethan B. Russo   Frontiers in Plant Science

Future Aspects for Cannabinoids in Breast Cancer Therapy

(2019) Terézia Kisková et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

(2019) Natasha Irrera et al.   Biomolecules

Terpenoids and Phytocannabinoids Co-Produced in Cannabis Sativa Strains Show Specific Interaction for Cell Cytotoxic Activity

(2019) Dvora Namdar et al.   MOLECULES

Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer

(2018) Sandra Blasco-Benito et al.   BIOCHEMICAL PHARMACOLOGY

Caryophyllane sesquiterpenes inhibit DNA-damage by tobacco smoke in bacterial and mammalian cells

(2018) Silvia Di Giacomo et al.   FOOD AND CHEMICAL TOXICOLOGY

Cannabinoids in cancer treatment: Therapeutic potential and legislation

(2018) Barbara Dariš et al.   Bosnian Journal of Basic Medical Sciences

A new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis

(2018) Paula Berman et al.   Scientific Reports

Valorizing industrial hemp (Cannabis sativa L.) by-products: Cannabidiol enrichment in the inflorescence essential oil optimizing sample pre-treatment prior to distillation

(2018) Dennis Fiorini et al.   INDUSTRIAL CROPS AND PRODUCTS

Pharmacological Foundations of Cannabis Chemovars

(2017) Mark Lewis et al.   PLANTA MEDICA

Comparing hemp (Cannabis sativa L.) cultivars for dual-purpose production under contrasting environments

(2016) K. Tang et al.   INDUSTRIAL CROPS AND PRODUCTS

Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes

(2016) Oier Aizpurua-Olaizola et al.   JOURNAL OF NATURAL PRODUCTS

Therapeutic potential of cannabis-related drugs

(2016) Stephen P.H. Alexander   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

(2016) Ester Pagano et al.   Frontiers in Pharmacology

The Endocannabinoid System and its Modulation by Phytocannabinoids

(2015) Vincenzo Di Marzo et al.   Neurotherapeutics

Interaction of β-caryophyllene and β-caryophyllene oxide with phospholipid bilayers: Differential scanning calorimetry study

(2015) Maria Grazia Sarpietro et al.   THERMOCHIMICA ACTA

Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect

(2013) Marta Solinas et al.   PLoS One

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

(2011) Ethan B Russo   BRITISH JOURNAL OF PHARMACOLOGY

Cassia angustifolia Extract Is Not Hepatotoxic in an in vitro and in vivo Study

(2011) A. Vitalone et al.   PHARMACOLOGY

Interaction between cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC): influence of administration interval and dose ratio between the cannabinoids

(2011) Antonio Waldo Zuardi et al.   PSYCHOPHARMACOLOGY

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

(2010) Sean D. McAllister et al.   BREAST CANCER RESEARCH AND TREATMENT

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

(2010) Iain Brown et al.   CARCINOGENESIS

Beta-caryophyllene is a dietary cannabinoid

(2008) Jürg Gertsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA