Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression

Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances migration and inhibits apoptosis of hepatocellular carcinoma cell HepG2

(2017) Bee-Piao Huang et al.   International Journal of Medical Sciences

MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro

(2017) Weifeng Yao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of glycoprotein 78 and cidec in hepatic steatosis

(2017) Jie Li et al.   Molecular Medicine Reports

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

(2017) Bodil Ingerslev et al.   Molecular Metabolism

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α

(2017) Pedro Latorre et al.   PLoS One

Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis

(2017) Pi-Jung Hsiao et al.   Scientific Reports

MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells

(2016) Won-Mo Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

(2016) Mohammad Zarei et al.   DIABETES

Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity

(2016) CHIN-CHANG CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

(2016) Jacek R. Wiśniewski et al.   Journal of Proteomics

Impaired insulin action in the liver, but not in adipose tissue or muscle, is a distinct metabolic feature of impaired fasting glucose in obese humans

(2016) Kasper W. ter Horst et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease

(2016) Liang Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Insulin Resistance Induces Posttranslational Hepatic Sortilin 1 Degradation in Mice

(2015) Jibiao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

(2015) Wieneke Dijk et al.   eLife

Higher Protein Kinase C ζ in Fatty Rat Liver and Its Effect on Insulin Actions in Primary Hepatocytes

(2015) Wei Chen et al.   PLoS One

Strategies for immortalization of primary hepatocytes

(2014) Eva Ramboer et al.   JOURNAL OF HEPATOLOGY

Lycopene Metabolite, Apo-10'-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet-Promoted Hepatic Inflammation and Tumorigenesis in Mice

(2013) B. C. Ip et al.   Cancer Prevention Research

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Wnt/β-Catenin Signaling Protects Mouse Liver against Oxidative Stress-induced Apoptosis through the Inhibition of Forkhead Transcription Factor FoxO3

(2013) Guo-Zhong Tao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA 33 Regulates Glucose Metabolism

(2013) C. M. Ramirez et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor β/δ and Protects Against Fatty Acid–Induced Oxidative Stress

(2010) Anastasia Georgiadi et al.   CIRCULATION RESEARCH

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

(2009) Sander Kersten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

Consequences of Lipid Droplet Coat Protein Downregulation in Liver Cells: Abnormal Lipid Droplet Metabolism and Induction of Insulin Resistance

(2008) M. Bell et al.   DIABETES