Involvement of the ghrelin system in the maintenance of oxycodone self-administration: converging evidence from endocrine, pharmacologic and transgenic approaches

A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data

(2021) Sara L. Deschaine et al.   ADDICTION BIOLOGY

Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral β1 receptors

(2021) Zhi-Bing You et al.   NEUROPSYCHOPHARMACOLOGY

(±)VK4‐40, a novel dopamine D 3 receptor partial agonist, attenuates cocaine reward and relapse in rodents

(2020) Chloe J. Jordan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder

(2019) Mehdi Farokhnia et al.   PHYSIOLOGY & BEHAVIOR

LEAP2 changes with body mass and food intake in humans and mice

(2019) Bharath K. Mani et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents

(2019) Md Nurul Islam et al.   JOURNAL OF ENDOCRINOLOGY

Ghrelin receptor antagonism of fentanyl-induced conditioned place preference, intravenous self-administration, and dopamine release in the nucleus accumbens in rats

(2019) Magdalena Sustkova-Fiserova et al.   ADDICTION BIOLOGY

Ghrelin Signaling: GOAT and GHS-R1a Take a LEAP in Complexity

(2019) Alfonso Abizaid et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction

(2019) Tracey M. D’Cunha et al.   PSYCHOPHARMACOLOGY

Ghrelin modulates mesolimbic reactivity to alcohol cues in alcohol-addicted subjects: a functional imaging study

(2018) Anne Koopmann et al.   ADDICTION BIOLOGY

Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder

(2018) Laurel S. Morris et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The Homeostatic Force of Ghrelin

(2018) Shigehisa Yanagi et al.   Cell Metabolism

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

(2018) Xuecai Ge et al.   Cell Metabolism

Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model

(2018) L. J. Zallar et al.   INTERNATIONAL JOURNAL OF OBESITY

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

(2018) Mary R. Lee et al.   MOLECULAR PSYCHIATRY

Ghrelin transport across the blood–brain barrier can occur independently of the growth hormone secretagogue receptor

(2018) Elizabeth M. Rhea et al.   Molecular Metabolism

Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects

(2018) Zhi-Bing You et al.   NEUROPSYCHOPHARMACOLOGY

Cocaine and cocaine expectancy increase growth hormone, ghrelin, GLP-1, IGF-1, adiponectin, and corticosterone while decreasing leptin, insulin, GIP, and prolactin

(2018) Zhi-Bing You et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus

(2017) Mohammad I. Murtuza et al.   JOURNAL OF NEUROCHEMISTRY

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals

(2017) M Farokhnia et al.   MOLECULAR PSYCHIATRY

The dopamine motive system: implications for drug and food addiction

(2017) Nora D. Volkow et al.   NATURE REVIEWS NEUROSCIENCE

Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats

(2017) Pavel Jerabek et al.   NEUROCHEMISTRY INTERNATIONAL

The novel dopamine D3 receptor antagonists/partial agonists CAB2-015 and BAK4-54 inhibit oxycodone-taking and oxycodone-seeking behavior in rats

(2017) Zhi-Bing You et al.   NEUROPHARMACOLOGY

Relationship between Nonmedical Prescription-Opioid Use and Heroin Use

(2016) Wilson M. Compton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections

(2016) Raymond A Pederson et al.   Journal of Diabetes Investigation

Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor

(2015) Andras Kern et al.   CELL

A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice

(2015) Jörgen A. Engel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Nonmedical Prescription Opioid Use in Childhood and Early Adolescence Predicts Transitions to Heroin Use in Young Adulthood: A National Study

(2015) Magdalena Cerdá et al.   JOURNAL OF PEDIATRICS

Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine

(2015) Zhi-Bing You et al.   NEUROPSYCHOPHARMACOLOGY

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

(2015) John R Mantsch et al.   NEUROPSYCHOPHARMACOLOGY

Intravenous Ghrelin Administration Increases Alcohol Craving in Alcohol-Dependent Heavy Drinkers: A Preliminary Investigation

(2014) Lorenzo Leggio et al.   BIOLOGICAL PSYCHIATRY

Review of Novel Aspects of the Regulation of Ghrelin Secretion

(2014) Omar Massadi et al.   CURRENT DRUG METABOLISM

Ghrelin Acts as an Interface between Physiological State and Phasic Dopamine Signaling

(2014) J. J. Cone et al.   JOURNAL OF NEUROSCIENCE

Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers

(2014) N D Volkow et al.   MOLECULAR PSYCHIATRY

Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

(2014) Magdalena Sustkova-Fiserova et al.   PSYCHOPHARMACOLOGY

A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear

(2013) R M Meyer et al.   MOLECULAR PSYCHIATRY

Glucocorticoid receptor expression and sub-cellular localization in dopamine neurons of the rat midbrain

(2013) E. Hensleigh et al.   NEUROSCIENCE LETTERS

Ghrelin and ghrelin receptor modulation of psychostimulant action

(2013) Paul J. Wellman et al.   Frontiers in Neuroscience

Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure

(2012) S. M. Groman et al.   JOURNAL OF NEUROSCIENCE

Concomitant Release of Ventral Tegmental Acetylcholine and Accumbal Dopamine by Ghrelin in Rats

(2012) Elisabet Jerlhag et al.   PLoS One

The Amygdala as a Neurobiological Target for Ghrelin in Rats: Neuroanatomical, Electrophysiological and Behavioral Evidence

(2012) Mayte Alvarez-Crespo et al.   PLoS One

A limited role for ghrelin in heroin self-administration and food deprivation-induced reinstatement of heroin seeking in rats

(2011) Tia Maric et al.   ADDICTION BIOLOGY

Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats

(2011) Sara Landgren et al.   ADDICTION BIOLOGY

Vagal Stimulation Modulates Inflammation through a Ghrelin Mediated Mechanism in Traumatic Brain Injury

(2011) Vishal Bansal et al.   INFLAMMATION

The role of the central ghrelin system in reward from food and chemical drugs

(2011) Suzanne L. Dickson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Common cellular and molecular mechanisms in obesity and drug addiction

(2011) Paul J. Kenny   NATURE REVIEWS NEUROSCIENCE

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system

(2010) Elisabet Jerlhag et al.   ADDICTION BIOLOGY

Ventral Tegmental Area Leptin Receptor Neurons Specifically Project to and Regulate Cocaine- and Amphetamine-Regulated Transcript Neurons of the Extended Central Amygdala

(2010) R. L. Leshan et al.   JOURNAL OF NEUROSCIENCE

Ghrelin secretion stimulated by  1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal adaptations, neuroendocrine and immune correlates of heroin self-administration

(2009) R.J. Weber et al.   BRAIN BEHAVIOR AND IMMUNITY

Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity

(2009) B.M. Geiger et al.   NEUROSCIENCE

Requirement of central ghrelin signaling for alcohol reward

(2009) E. Jerlhag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine

(2008) Elisabet Jerlhag   ADDICTION BIOLOGY

Possible entrainment of ghrelin to habitual meal patterns in humans

(2008) Julie M. Frecka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat.

(2008) Jon F. Davis et al.   BEHAVIORAL NEUROSCIENCE

Food deprivation-like effects of neuropeptide Y on heroin self-administration and reinstatement of heroin seeking in rats

(2008) Tia Maric et al.   BEHAVIOURAL BRAIN RESEARCH

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens

(2008) Davide Quarta et al.   NEUROCHEMISTRY INTERNATIONAL

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats

(2007) Paul J. Wellman et al.   REGULATORY PEPTIDES

The autonomic nervous system regulates gastric ghrelin secretion in rats

(2007) Hiroshi Hosoda et al.   REGULATORY PEPTIDES