Thermal Unfolding of the Human Serotonin Transporter: Differential Effect by Stabilizing and Destabilizing Mutations and Cholesterol on Thermodynamic and Kinetic Stability

Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding

(2021) Eray Esendir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

(2021) Shreyas Bhat et al.   eLife

Functional impact of the G279S substitution in the adenosine A1-receptor (A1R-G279S), a mutation associated with Parkinson's disease

(2020) Shahrooz Nasrollahi-Shirazi et al.   MOLECULAR PHARMACOLOGY

Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits

(2020) Shreyas Bhat et al.   PHARMACOLOGY & THERAPEUTICS

Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis

(2019) Justin T. Marinko et al.   CHEMICAL REVIEWS

Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome

(2019) Ali El-Kasaby et al.   NEUROPHARMACOLOGY

How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers

(2019) Shreyas Bhat et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

(2019) Jonathan A. Coleman et al.   NATURE

Promoting transparency and reproducibility in enhanced molecular simulations

(2019)   NATURE METHODS

The genetic landscape of the human solute carrier (SLC) transporter superfamily

(2019) Lena Schaller et al.   HUMAN GENETICS

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter

(2018) Louise Laursen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDB2ENTROPY and PDB2TRENT: Conformational and Translational–Rotational Entropy from Molecular Ensembles

(2018) Federico Fogolari et al.   Journal of Chemical Information and Modeling

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

(2018) Jonathan A. Coleman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

(2018) Jonathan A. Coleman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional selectivity and partial efficacy at the monoamine transporters: a unified model of allosteric modulation and amphetamine-induced substrate release

(2018) Peter S Hasenhuetl et al.   MOLECULAR PHARMACOLOGY

Pharmacochaperoning in aDrosophilamodel system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism

(2017) H. M. Mazhar Asjad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

(2017) Shreyas Bhat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification Systems of Secondary Active Transporters

(2017) Emelie Perland et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sequence dependency of canonical base pair opening in the DNA double helix

(2017) Viveca Lindahl et al.   PLoS Computational Biology

Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter

(2016) Peter S. Hasenhuetl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells

(2016) Pieter Beerepoot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Rescue of a MisfoldedDrosophila melanogasterDopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones

(2016) Ameya Kasture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics

(2016) Mariarosaria Ferraro et al.   PLoS One

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Rigidity versus flexibility: the dilemma of understanding protein thermal stability

(2015) Andrey Karshikoff et al.   FEBS Journal

A Salt Bridge Linking the First Intracellular Loop with the C Terminus Facilitates the Folding of the Serotonin Transporter

(2015) Florian Koban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

(2015) Harald H. Sitte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation

(2015) Evan M. Green et al.   PLoS One

Structure and Regulatory Interactions of the Cytoplasmic Terminal Domains of Serotonin Transporter

(2014) Cristina Fenollar-Ferrer et al.   BIOCHEMISTRY

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter

(2014) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Time-Independent Free Energy Estimator for Metadynamics

(2014) Pratyush Tiwary et al.   JOURNAL OF PHYSICAL CHEMISTRY B

PLUMED 2: New feathers for an old bird

(2013) Gareth A. Tribello et al.   COMPUTER PHYSICS COMMUNICATIONS

Going Backward: A Flexible Geometric Approach to Reverse Transformation from Coarse Grained to Atomistic Models

(2013) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Effects of the Chemical Chaperone 4-Phenylbutylate on the Function of the Serotonin Transporter (SERT) Expressed in COS-7 Cells

(2013) Masayuki Fujiwara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Another Piece of the Membrane Puzzle: Extending Slipids Further

(2012) Joakim P. M. Jämbeck et al.   Journal of Chemical Theory and Computation

An Extension and Further Validation of an All-Atomistic Force Field for Biological Membranes

(2012) Joakim P. M. Jämbeck et al.   Journal of Chemical Theory and Computation

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Importance of cholesterol in dopamine transporter function

(2012) Kymry T. Jones et al.   JOURNAL OF NEUROCHEMISTRY

Unifying Concept of Serotonin Transporter-associated Currents

(2011) Klaus Schicker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Protein kinetic stability

(2010) Jose M. Sanchez-Ruiz   BIOPHYSICAL CHEMISTRY

Mutations in the Carboxyl-terminal SEC24 Binding Motif of the Serotonin Transporter Impair Folding of the Transporter

(2010) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation

(2010) Maarten G. Wolf et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

Well-Tempered Metadynamics: A Smoothly Converging and Tunable Free-Energy Method

(2008) Alessandro Barducci et al.   PHYSICAL REVIEW LETTERS