Application of a High-Throughput Relative Chemical Stability Assay to Screen Therapeutic Protein Formulations by Assessment of Conformational Stability and Correlation to Aggregation Propensity

Published 2015 View Full Article

Title

Application of a High-Throughput Relative Chemical Stability Assay to Screen Therapeutic Protein Formulations by Assessment of Conformational Stability and Correlation to Aggregation Propensity

Authors

Keywords

chemical denaturation, protein folding/refolding, circular dichroism, calorimetry (DSC), intrinsic fluorescence, guanidine-HCl, urea, protein aggregation, formulation, robotic automation

Journal

JOURNAL OF PHARMACEUTICAL SCIENCES

Volume 104, Issue 5, Pages 1632-1640

Publisher

Elsevier BV

Online

2015-03-11

DOI

10.1002/jps.24408

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