Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

(2021) Joel Simrén et al.   Alzheimers & Dementia

Accelerated inflammatory aging in Alzheimer’s disease and its relation to amyloid, tau, and cognition

(2021) Nicholas C. Cullen et al.   Scientific Reports

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease

(2021) Alexis Moscoso et al.   JAMA Neurology

Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease

(2021) Pratishtha Chatterjee et al.   Translational Psychiatry

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology

(2021) Nicholas J. Ashton et al.   ACTA NEUROPATHOLOGICA

Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study

(2021) Adam M. Brickman et al.   Alzheimers & Dementia

The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers

(2021) N. J. Ashton et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau

(2021) Oskar Hansson et al.   Alzheimers & Dementia

A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

(2021) Tim West et al.   Molecular Neurodegeneration

Highly specific and ultrasensitive plasma test detects Abeta(1–42) and Abeta(1–40) in Alzheimer’s disease

(2021) Elisabeth H. Thijssen et al.   Scientific Reports

A neurologist’s perspective on serum neurofilament light in the memory clinic: a prospective implementation study

(2021) E. A. J. Willemse et al.   Alzheimers Research & Therapy

Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment

(2021) Claudia Cicognola et al.   Alzheimers Research & Therapy

Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study

(2021) Elisabeth H Thijssen et al.   LANCET NEUROLOGY

Biomarkers for neurodegenerative diseases

(2021) Oskar Hansson   NATURE MEDICINE

Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures

(2021) Sebastian Palmqvist et al.   NATURE MEDICINE

Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

(2021) Michelle M. Mielke et al.   JAMA Neurology

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

(2020) Carolin Heller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia

(2020) Shorena Janelidze et al.   NATURE MEDICINE

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

(2020) Elisabeth H. Thijssen et al.   NATURE MEDICINE

Plasma amyloid is associated with the rate of cognitive decline in cognitively normal elderly: the SCIENCe project

(2020) Inge M.W. Verberk et al.   NEUROBIOLOGY OF AGING

Cognitively unimpaired adults’ reactions to disclosure of amyloid PET scan results

(2020) Emily A. Largent et al.   PLoS One

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

(2020) Michael Khalil et al.   Nature Communications

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels

(2020) Ali Manouchehrinia et al.   Annals of Clinical and Translational Neurology

Neurofilaments: neurobiological foundations for biomarker applications

(2020) Arie R Gafson et al.   BRAIN

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

(2020) Thomas K Karikari et al.   LANCET NEUROLOGY

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

(2020) Shorena Janelidze et al.   Nature Communications

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

(2020) Nicolas R. Barthélemy et al.   Alzheimers Research & Therapy

Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline

(2020) Juan Lantero Rodriguez et al.   ACTA NEUROPATHOLOGICA

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration

(2020) Alberto Benussi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2020) Juan Fortea et al.   LANCET

Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study

(2020) Yakeel T Quiroz et al.   LANCET NEUROLOGY

Comparing progression biomarkers in clinical trials of early Alzheimer’s disease

(2020) Nicholas C. Cullen et al.   Annals of Clinical and Translational Neurology

Remote Blood Biomarkers of Longitudinal Cognitive Outcomes in a Population Study

(2020) Kumar B. Rajan et al.   ANNALS OF NEUROLOGY

Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease

(2020) Niklas Mattsson-Carlgren et al.   BRAIN

Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage

(2020) Breton M. Asken et al.   JOURNAL OF ALZHEIMERS DISEASE

Serum Glial Fibrillary Acidic Protein (GFAP) Is a Marker of Disease Severity in Frontotemporal Lobar Degeneration

(2020) Alberto Benussi et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer’s Disease

(2020) Yen Ying Lim et al.   JOURNAL OF ALZHEIMERS DISEASE

Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

(2020) Thomas K. Karikari et al.   MOLECULAR PSYCHIATRY

Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology

(2020) Inge M. W. Verberk et al.   Alzheimers Research & Therapy

Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum

(2020) Alexis Moscoso et al.   BRAIN

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome

(2020) Melissa E. Petersen et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma tau and neurofilament light in frontotemporal lobar degeneration and Alzheimer's disease

(2020) Ignacio Illán-Gala et al.   NEUROLOGY

Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

(2020) Jasmeer P. Chhatwal et al.   Nature Communications

Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis

(2020) Steffi De Meyer et al.   Alzheimers Research & Therapy

Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

(2020) Julia Stockmann et al.   Alzheimers Research & Therapy

Variations in consecutive serum neurofilament light levels in healthy controls and multiple sclerosis patients

(2020) C. Bridel et al.   Multiple Sclerosis and Related Disorders

Assessment of Plasma Amyloid-β42/40 and Cognitive Decline Among Community-Dwelling Older Adults

(2020) Kelly Virecoulon Giudici et al.   JAMA Network Open

Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease

(2020) Shorena Janelidze et al.   JAMA Neurology

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer’s Disease and Correlates with Cognitive Impairment

(2019) Patrick Oeckl et al.   JOURNAL OF ALZHEIMERS DISEASE

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

(2019) Oliver Preische et al.   NATURE MEDICINE

Assessment of Racial Disparities in Biomarkers for Alzheimer Disease

(2019) John C. Morris et al.   JAMA Neurology

Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes

(2019) Matthew P. Pase et al.   JAMA Neurology

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

(2019) Carla M. Startin et al.   Alzheimers Research & Therapy

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease

(2019) Philip S. J. Weston et al.   Alzheimers Research & Therapy

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

(2019) Andrea Vergallo et al.   Alzheimers & Dementia

Neurofilament light chain as a biomarker in neurological disorders

(2019) Lorenzo Gaetani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease

(2019) Niklas Mattsson et al.   JAMA Neurology

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

(2019) Lisa Vermunt et al.   Alzheimers & Dementia

Serum neurofilaments as candidate biomarkers of natalizumab‐PML

(2019) Floor C. Loonstra et al.   ANNALS OF NEUROLOGY

Brain Amyloid-β Deposition and Blood Biomarkers in Patients with Clinically Diagnosed Alzheimer’s Disease

(2019) Wei-Wei Li et al.   JOURNAL OF ALZHEIMERS DISEASE

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

(2019) Suzanne E. Schindler et al.   NEUROLOGY

Plasma and CSF neurofilament light

(2019) Michelle M. Mielke et al.   NEUROLOGY

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology

(2019) Claire Bridel et al.   JAMA Neurology

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

(2019) Sebastian Palmqvist et al.   JAMA Neurology

Profiling individual clinical responses by high-frequency serum neurofilament assessment in MS

(2019) Katja Akgün et al.   Neurology-Neuroimmunology & Neuroinflammation

The “rights” of precision drug development for Alzheimer’s disease

(2019) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

(2019) Ingrid S van Maurik et al.   LANCET NEUROLOGY

Plasma biomarkers of astrocytic and neuronal dysfunction in early‐ and late‐onset Alzheimer's disease

(2019) Fanny M. Elahi et al.   Alzheimers & Dementia

Obesity affects brain structure and function- rescue by bariatric surgery?

(2019) Minke H.C. Nota et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

(2018) Michelle M. Mielke et al.   Alzheimers & Dementia

Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease

(2018) Courtney L. Sutphen et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Amyloid blood biomarker detects Alzheimer's disease

(2018) Andreas Nabers et al.   EMBO Molecular Medicine

Differences in Obesity Prevalence by Demographic Characteristics and Urbanization Level Among Adults in the United States, 2013-2016

(2018) Craig M. Hales et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Plasma tau is increased in frontotemporal dementia

(2018) Martha S Foiani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

(2018) Brian A Gordon et al.   LANCET NEUROLOGY

High performance plasma amyloid-β biomarkers for Alzheimer’s disease

(2018) Akinori Nakamura et al.   NATURE

Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study

(2018) Saima Hilal et al.   Alzheimers Research & Therapy

Plasma amyloid as pre-screener for the earliest Alzheimer's pathological changes

(2018) Inge M.W. Verberk et al.   ANNALS OF NEUROLOGY

Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2018) Juan Fortea et al.   LANCET NEUROLOGY

Neurofilaments as biomarkers in neurological disorders

(2018) Michael Khalil et al.   Nature Reviews Neurology

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease

(2018) Zhicheng Chen et al.   Alzheimers & Dementia

Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer’s disease

(2018) Raquel Sánchez-Valle et al.   Alzheimers Research & Therapy

Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)

(2018) Itziar de Rojas et al.   Alzheimers Research & Therapy

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

(2017) Giovanni B Frisoni et al.   LANCET NEUROLOGY

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort

(2016) Jeffrey L. Dage et al.   Alzheimers & Dementia

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

The ARIC-PET amyloid imaging study

(2016) Rebecca F. Gottesman et al.   NEUROLOGY

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

Desire for predictive testing for Alzheimer’s disease and impact on advance care planning: a cross-sectional study

(2016) Meera Sheffrin et al.   Alzheimers Research & Therapy

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

(2016) Henrik Zetterberg et al.   JAMA Neurology

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

(2016) Magnus Gisslén et al.   EBioMedicine

Plasma β-amyloid in Alzheimer’s disease and vascular disease

(2016) Shorena Janelidze et al.   Scientific Reports

Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer's Disease

(2014) A. M. Fagan et al.   Science Translational Medicine

Plasma tau levels in Alzheimer's disease

(2013) Henrik Zetterberg et al.   Alzheimers Research & Therapy

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Racial and Ethnic Differences in Kidney Function Decline among Persons without Chronic Kidney Disease

(2011) C. A. Peralta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING