Astragalus polysaccharide alleviated hepatocyte senescence via autophagy pathway

Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro

(2020) Yinyin Tan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury

(2020) Jianbin Bi et al.   Oxidative Medicine and Cellular Longevity

The Role of Autophagy for the Regeneration of the Aging Liver

(2020) Fengming Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

(2020) Junyan Wang et al.   Cell Death & Disease

Mitochondrial dynamics and their potential as a therapeutic target

(2019) B.N. Whitley et al.   MITOCHONDRION

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis

(2019) Ming-yong Li et al.   Cell Death & Disease

The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells

(2019) Nicola Alessio et al.   Aging-US

Hepatic senescence, the good and the bad

(2019) Nazmul Huda et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Conserved aging-related signatures of senescence and inflammation in different tissues and species

(2019) Emanuel Barth et al.   Aging-US

Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

(2019) Ziyan Zhang et al.   Autophagy

Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation

(2019) Wenfang Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The potential role of necroptosis in inflammaging and aging

(2019) Gordon H. Royce et al.   GeroScience

Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells

(2018) Chunteng Jiang et al.   TOXICOLOGY

Tumor cell escape from therapy-induced senescence

(2018) Tareq Saleh et al.   BIOCHEMICAL PHARMACOLOGY

Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes

(2018) Ruixin Zhang et al.   MOLECULES

Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-κB p65 signal pathway and protects mice from CVB3-induced virus myocarditis

(2018) Tianlong Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

(2016) Antero Salminen et al.   AGEING RESEARCH REVIEWS

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Aging and chronic disease as independent causative factors for death and a programmed onset for chronic disease

(2015) Liu Hui   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Autophagy and apoptosis in liver injury

(2015) Kewei Wang   CELL CYCLE

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation

(2014) Dan Shao et al.   Cell Metabolism

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING