Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)

(2015) Kenneth C Kalunian et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role ofPTPN22Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human

(2015) David J. Rawlings et al.   JOURNAL OF IMMUNOLOGY

Type 1 interferon-induced IL-7 maintains CD8+ T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis

(2014) Lifei Hou et al.   Cellular & Molecular Immunology

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4+T cells

(2013) Philippa Hillyer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ–Induced Signaling in Human Monocytes

(2013) Marianne R. Spalinger et al.   GASTROENTEROLOGY

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

Genetic susceptibility to SLE: Recent progress from GWAS

(2013) Yong Cui et al.   JOURNAL OF AUTOIMMUNITY

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study

(2012) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Anti-IFN- /  Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice

(2012) R. Baccala et al.   JOURNAL OF IMMUNOLOGY

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

(2011) T. Habib et al.   JOURNAL OF IMMUNOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production

(2011) Sharon A. Chung et al.   PLoS Genetics

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

Type I interferons: crucial participants in disease amplification in autoimmunity

(2010) John C. Hall et al.   Nature Reviews Rheumatology

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease

(2009) H. Agrawal et al.   JOURNAL OF IMMUNOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

(2009) Taku Sato et al.   NATURE MEDICINE

ThePTPN22C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-α activity and low tumor necrosis factor α levels in patients with lupus

(2008) Silvia N. Kariuki et al.   ARTHRITIS AND RHEUMATISM

Severe Systemic Lupus Erythematosus Induced by Antiviral Treatment for Hepatitis C

(2008) Vincent Ho et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE