Alpha-B-Crystallin Induces an Immune-Regulatory and Antiviral Microglial Response in Preactive Multiple Sclerosis Lesions

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection

(2012) Cletus Cheyuo et al.   BIOLOGICAL CHEMISTRY

Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles

(2012) Johannes M. van Noort et al.   BIOMATERIALS

The Interplay between Indoleamine 2,3-Dioxygenase 1 (IDO1) and Cyclooxygenase (COX)-2 In Chronic Inflammation and Cancer

(2012) A. Cesario et al.   CURRENT MEDICINAL CHEMISTRY

Chemokine receptor CXCR2: Physiology regulator and neuroinflammation controller?

(2012) Mike Veenstra et al.   JOURNAL OF NEUROIMMUNOLOGY

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

(2012) Jack van Horssen et al.   Journal of Neuroinflammation

Beneficial Effects of  B-Crystallin in Spinal Cord Contusion Injury

(2012) A. Klopstein et al.   JOURNAL OF NEUROSCIENCE

Association between pathological and MRI findings in multiple sclerosis

(2012) Massimo Filippi et al.   LANCET NEUROLOGY

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Wnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against Aß Toxicity

(2012) Lorena Varela-Nallar et al.   Neurodegenerative Diseases

Alpha B-crystallin prevents the arrhythmogenic effects of particulate matter isolated from ambient air by attenuating oxidative stress

(2012) Hyelim Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations

(2011) Natalia M. Moll et al.   ANNALS OF NEUROLOGY

The role of the PD-1 pathway in autoimmunity and peripheral tolerance

(2011) Brian T. Fife et al.   Annals of the New York Academy of Sciences

αB-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion

(2011) Jeffrey B. Velotta et al.   ANNALS OF THORACIC SURGERY

Oxidative damage in multiple sclerosis lesions

(2011) L. Haider et al.   BRAIN

Functional rescue of experimental ischemic optic neuropathy with αB-crystallin

(2011) S Pangratz-Fuehrer et al.   EYE

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

The cardinal role of the phospholipase A2/cyclooxygenase-2/prostaglandin E synthase/prostaglandin E2 (PCPP) axis in inflammostasis

(2011) A. D. Mancini et al.   INFLAMMATION RESEARCH

MCP-1-induced protein attenuates endotoxin-induced myocardial dysfunction by suppressing cardiac NF-кB activation via inhibition of IкB kinase activation

(2011) Jianli Niu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

(2011) Ahmet Arac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus

(2010) Hilmar R.J. van Weering et al.   HIPPOCAMPUS

αB-Crystallin Is a Target for Adaptive Immune Responses and a Trigger of Innate Responses in Preactive Multiple Sclerosis Lesions

(2010) Johannes M. van Noort et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing–remitting or secondary progressive multiple sclerosis

(2010) Timothy L Vollmer et al.   Multiple Sclerosis Journal

Regulation of leukocyte recruitment by the long pentraxin PTX3

(2010) Livija Deban et al.   NATURE IMMUNOLOGY

Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury

(2010) M. Lv et al.   NEUROSCIENCE

Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells

(2010) Simon J. Waddell et al.   PLoS One

ABINs: A20 binding inhibitors of NF-κB and apoptosis signaling

(2009) Lynn Verstrepen et al.   BIOCHEMICAL PHARMACOLOGY

Old Friends in New Constellations - the Hematopoetic Growth Factors G-CSF, GMCSF, and EPO for the Treatment of Neurological Diseases

(2008) M. Maurer et al.   CURRENT MEDICINAL CHEMISTRY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY