Access to gem-Difluoroalkenes via Organic Photoredox-Catalyzed gem-Difluoroallylation of Alkyl Iodides

2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions

(2021) Bingnan Du et al.   Nature Communications

Photocatalytic Deoxygenative Carboimination towards Functionalized Pyrrolines by Using Unstrained γ , δ ‐Unsaturated Oximes

(2021) Min Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Photoredox/Hydrogen Atom Transfer Cocatalyzed C–H Difluoroallylation of Amides, Ethers, and Alkyl Aldehydes

(2021) Yuan-Qiang Guo et al.   ORGANIC LETTERS

Site-Selective Defluorinative sp3 C–H Alkylation of Secondary Amides

(2021) Wen-Jun Yue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remote Regioselective Radical C–H Functionalization of Unactivated C–H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

(2021) Qu-Ping Hu et al.   ORGANIC LETTERS

Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions

(2021) Jingjing Zhang et al.   Nature Communications

Chromium-Catalyzed Allylic Defluorinative Ketyl Olefin Coupling

(2021) Chang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ni-Catalyzed Ligand-Controlled Regiodivergent Reductive Dicarbofunctionalization of Alkenes

(2021) Qi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox Generation of N-Centered Hydrazonyl Radicals Enables the Construction of Dihydropyrazole-Fused gem-Difluoroalkenes

(2021) Qi-Sheng Gao et al.   ORGANIC LETTERS

Visible-Light-Mediated C–I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator

(2021) Fuyang Yue et al.   ORGANIC LETTERS

C-F bond activation under transition-metal-free conditions

(2021) Han-Jun Ai et al.   Science China-Chemistry

Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride

(2020) Chengbo Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Mediated β-C–H gem-Difluoroallylation of Aldehydes and Cyclic Ketones through C–F Bond Cleavage of 1-Trifluoromethyl Alkenes

(2020) Devireddy Anand et al.   ORGANIC LETTERS

Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides

(2020) Timothée Constantin et al.   SCIENCE

Visible‐Light‐Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to gem‐Difluoroallylboranes

(2020) Guojun Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of gem-Difluoroalkenes by Copper-catalyzed Regioselective Hydrodefluorination of 1-Trifluoromethylalkenes

(2020) Yuki Kojima et al.   CHEMISTRY LETTERS

Regio- and Enantioselective Bromocyclization of Difluoroalkenes as a Strategy to Access Tetrasubstituted Difluoromethylene-Containing Stereocenters

(2020) Edward Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Titanocene-Catalyzed Reductive Domino Epoxide Ring Opening/Defluorinative Cross-Coupling Reaction

(2020) Zhiyang Lin et al.   ORGANIC LETTERS

Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow

(2020) Wai Chung Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkyltriflones in the Ramberg–Bäcklund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes

(2020) Yuuki Maekawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Access to gem-Difluoro Olefins via C–H Functionalization and Dual Role of Anilines

(2020) Zhen Yang et al.   ORGANIC LETTERS

Organo-photoredox catalyzed defluoroacetalation of α-trifluoromethyl alkenes for synthesis of masked γ,γ-difluoroallylic aldehydes

(2020) Pan Xiang et al.   TETRAHEDRON LETTERS

Synthesis of gem-Difluoroalkenes via Zn-Mediated Decarboxylative/Defluorinative Cross-Coupling

(2020) Hai-Wu Du et al.   ORGANIC LETTERS

Electrophilic iron catalyst paired with a lithium cation enables selective functionalization of non-activated aliphatic C-H bonds via metallocarbene intermediates

(2019) Miquel Costas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Defluorinative C(sp 3 )−P Bond Construction for the Synthesis of Phosphorylation gem ‐Difluoroalkenes under Catalyst‐ and Oxidant‐Free Conditions

(2019) Congyu Li et al.   Chemistry-An Asian Journal

Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents

(2019) Jun-Liang Zeng et al.   ORGANIC LETTERS

Reductive Allylic Defluorinative Cross-Coupling Enabled by Ni/Ti Cooperative Catalysis

(2019) Zhiyang Lin et al.   ORGANIC LETTERS

Photoinduced Single-Electron Transfer as an Enabling Principle in the Radical Borylation of Alkenes with NHC-Borane

(2019) Peng-Ju Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalysis of Radical Cyclizations from Alkyl Iodides under H2: Evidence for Electron Transfer from [CpV(CO)3H]−

(2018) Jonathan L. Kuo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

(2018) James P. Phelan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible Light-Mediated Trifluoromethylation of Fluorinated Alkenes via C−F Bond Cleavage

(2018) Liu-Hai Wu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Allylic Defluorinative Reductive Cross-Coupling

(2018) Yun Lan et al.   ACS Catalysis

A photocatalytic decarboxylative/defluorinative [4+3] annulation of o-hydroxyphenylacetic acids and trifluoromethyl alkenes: synthesis of fluorinated dihydrobenzoxepines

(2018) Haoguo Chen et al.   Organic Chemistry Frontiers

Cu/Chiral Phosphoric Acid-Catalyzed Asymmetric Three-Component Radical-Initiated 1,2-Dicarbofunctionalization of Alkenes

(2018) Jin-Shun Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C–F and C–O Bond Cleavage

(2018) Zhiyang Lin et al.   ACS Catalysis

Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes

(2017) Yang Liu et al.   ORGANIC LETTERS

Synthesis of Functionalized gem-Difluoroalkenes via a Photocatalytic Decarboxylative/Defluorinative Reaction

(2016) Tiebo Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

(2015) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Allylic C(sp3)–F Bond Activation of Trifluoromethyl Groups via β-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

(2015) Tomohiro Ichitsuka et al.   ACS Catalysis

Double CF Bond Activation through β-Fluorine Elimination: Nickel-Mediated [3+2] Cycloaddition of 2-Trifluoromethyl-1-alkenes with Alkynes

(2014) Tomohiro Ichitsuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C–F Bond Cleavage

(2013) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substitution of Two Fluorine Atoms in a Trifluoromethyl Group: Regioselective Synthesis of 3-Fluoropyrazoles

(2012) Kohei Fuchibe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Promoted CC Bond Cleavage: Photocatalytic Generation of Iminium Ions and Amino Radicals

(2012) Shunyou Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reduction of benzylic alcohols and α-hydroxycarbonyl compounds by hydriodic acid in a biphasic reaction medium

(2012) Michael Dobmeier et al.   Beilstein Journal of Organic Chemistry

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS