Chromium-Catalyzed Allylic Defluorinative Ketyl Olefin Coupling

Tuning the regioselective functionalization of trifluoromethylated dienes via lanthanum‐mediated single C‐F bond activation

(2021) Tarun Kumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photoredox/Hydrogen Atom Transfer Cocatalyzed C–H Difluoroallylation of Amides, Ethers, and Alkyl Aldehydes

(2021) Yuan-Qiang Guo et al.   ORGANIC LETTERS

Mechanistic Diversity of Low-Valent Chromium Catalysis: Cross-Coupling and Hydrofunctionalization

(2021) Xuefeng Cong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly γ‐Selective Arylation and Carbonylative Arylation of 3‐Bromo‐3,3‐difluoropropene via Nickel Catalysis

(2021) Ran Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Defluorinative sp3 C–H Alkylation of Secondary Amides

(2021) Wen-Jun Yue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NiH-Catalyzed Migratory Defluorinative Olefin Cross-Coupling: Trifluoromethyl-Substituted Alkenes as Acceptor Olefins to Form gem -Difluoroalkenes

(2020) Fenglin Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride

(2020) Chengbo Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light-Mediated β-C–H gem-Difluoroallylation of Aldehydes and Cyclic Ketones through C–F Bond Cleavage of 1-Trifluoromethyl Alkenes

(2020) Devireddy Anand et al.   ORGANIC LETTERS

Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones

(2020) Yuan-Qiang Guo et al.   ORGANIC LETTERS

Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay

(2020) Shun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Titanocene-Catalyzed Reductive Domino Epoxide Ring Opening/Defluorinative Cross-Coupling Reaction

(2020) Zhiyang Lin et al.   ORGANIC LETTERS

Merger of C–F and C–N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes

(2020) Youxiang Jin et al.   ORGANIC LETTERS

Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals

(2020) Chuan Zhu et al.   Nature Communications

Electroreductive Olefin–Ketone Coupling

(2020) Pengfei Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chromium-Catalyzed Cross-Couplings and Related Reactions

(2019) Jie Li et al.   SYNTHESIS-STUTTGART

Synthesis of gem-Difluoroalkenes by Merging Ni-Catalyzed C–F and C–C Bond Activation in Cross-Electrophile Coupling

(2019) Decai Ding et al.   ORGANIC LETTERS

Ni-Catalyzed Asymmetric Reductive Arylalkylation of Unactivated Alkenes

(2019) Youxiang Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Promoted Redox Neutral γ,γ-Difluoroallylation of Cycloketone Oxime Ethers with Trifluoromethyl Alkenes via C–C and C–F Bond Cleavage

(2019) Yuwei He et al.   ORGANIC LETTERS

Photocatalytic, Phosphoranyl Radical-Mediated N–O Cleavage of Strained Cycloketone Oximes

(2019) Peng-Ju Xia et al.   ORGANIC LETTERS

Nickel-Catalyzed Defluorinative Reductive Cross-Coupling Reaction of gem-Difluoroalkenes with Thiosulfonate or Selenium Sulfonate

(2019) Jian Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemodivergent and Stereoselective Construction of gem-Difluoroallylic Amines from Masked Difluorodiazo Reagents

(2019) Jun-Liang Zeng et al.   ORGANIC LETTERS

Reductive Allylic Defluorinative Cross-Coupling Enabled by Ni/Ti Cooperative Catalysis

(2019) Zhiyang Lin et al.   ORGANIC LETTERS

Catalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds

(2019) Hyowon Seo et al.   ORGANIC LETTERS

Enantioselective Copper-Catalyzed Defluoroalkylation Using Arylboronate-Activated Alkyl Grignard Reagents

(2018) Minyan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Copper-Catalyzed Reductive Defluorination of β-Trifluoromethylated Enones via Oxidative Homocoupling of Grignard Reagents

(2018) Xiaoting Wu et al.   ORGANIC LETTERS

Cu-Catalyzed tertiary alkylation of α-(trifluoromethyl)styrenes with tertiary alkylmagnesium reagents

(2018) Wenpeng Dai et al.   Organic Chemistry Frontiers

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Allylic Defluorinative Reductive Cross-Coupling

(2018) Yun Lan et al.   ACS Catalysis

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C–F and C–O Bond Cleavage

(2018) Zhiyang Lin et al.   ACS Catalysis

β-Selective Reductive Coupling of Alkenylpyridines with Aldehydes and Imines via Synergistic Lewis Acid/Photoredox Catalysis

(2017) Katarzyna N. Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes

(2017) Yang Liu et al.   ORGANIC LETTERS

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis

(2016) Li Qi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Difluoromethylenation of Carbonyl Compounds by Using TMSCF3: The Right Conditions

(2016) Sankarganesh Krishnamoorthy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized gem-Difluoroalkenes via a Photocatalytic Decarboxylative/Defluorinative Reaction

(2016) Tiebo Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed Asymmetric Arylation/Defluorination of 1-(Trifluoromethyl)alkenes Forming Enantioenriched 1,1-Difluoroalkenes

(2016) Yinhua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction of Diazo Compounds with Difluorocarbene: An Efficient Approach towards 1,1-Difluoroolefins

(2015) Zhikun Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

(2015) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

(2015) Kohsuke Aikawa et al.   ORGANIC LETTERS

Cross-Coupling between Difluorocarbene and Carbene-Derived Intermediates Generated from Diazocompounds for the Synthesis of gem-Difluoroolefins

(2015) Jian Zheng et al.   ORGANIC LETTERS

Nickel-Catalyzed Allylic C(sp3)–F Bond Activation of Trifluoromethyl Groups via β-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

(2015) Tomohiro Ichitsuka et al.   ACS Catalysis

Cross-Coupling Reactions Using Samarium(II) Iodide

(2014) Michal Szostak et al.   CHEMICAL REVIEWS

gem-Difluoroolefination of Diaryl Ketones and Enolizable Aldehydes with Difluoromethyl 2-Pyridyl Sulfone: New Insights into the Julia-Kocienski Reaction

(2014) Bing Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Decarboxylative Julia-Kocienskigem-Difluoro-Olefination of 2-Pyridinyl Sulfonyldifluoroacetate

(2014) Xiao-Ping Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

(2013) Jian Zheng et al.   CHEMICAL COMMUNICATIONS

Conversion between Difluorocarbene and Difluoromethylene Ylide

(2013) Jian Zheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C–F Bond Cleavage

(2013) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Ketyl-Olefin Cyclizations Enabled by Proton-Coupled Electron Transfer

(2013) Kyle T. Tarantino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Electron-Way: Metal-Catalyzed Reductive Umpolung Reactions of Saturated and α,β-Unsaturated Carbonyl Derivatives

(2013) Jan Streuff   SYNTHESIS-STUTTGART

Substitution of Two Fluorine Atoms in a Trifluoromethyl Group: Regioselective Synthesis of 3-Fluoropyrazoles

(2012) Kohei Fuchibe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Metal-Catalyzed Reactions of gem-Dihalovinyl Systems

(2011) Giorgio Chelucci   CHEMICAL REVIEWS

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS

Isocombretastatins A versus Combretastatins A: The ForgottenisoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent

(2009) Samir Messaoudi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis ofgem-Difluoroalkenes via β-Fluoride Elimination of Organorhodium(I)

(2008) Tomoya Miura et al.   CHEMISTRY LETTERS

A New Class of Substrates for Nucleophilic 5-endo-trig Cyclization, 2-Trifluoromethyl-1-alkenes: Synthesis of Five-Membered Hetero- and Carbocycles That Bear Fluorinated One-Carbon Units

(2008) Junji Ichikawa et al.   Chemistry-An Asian Journal