Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and β-catenin expression

Lysosomal Stress Response (LSR): Physiological Importance and Pathological Relevance

(2021) Koffi L. Lakpa et al.   Journal of Neuroimmune Pharmacology

HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species

(2021) Peter W. Halcrow et al.   Journal of Neuroimmune Pharmacology

Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation

(2020) Nabab Khan et al.   FASEB JOURNAL

Role of Divalent Cations in HIV-1 Replication and Pathogenicity

(2020) Nabab Khan et al.   Viruses-Basel

HIV Eradication Strategies: Implications for the Central Nervous System

(2019) Rebecca T. Veenhuis et al.   Current HIV/AIDS Reports

Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer’s disease

(2019) Nabab Khan et al.   BRAIN RESEARCH

BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation

(2019) Nabab Khan et al.   Scientific Reports

Circulating levels of ATP is a biomarker of HIV cognitive impairment

(2019) Stephani Velasquez et al.   EBioMedicine

Histone deacetylase–mediated regulation of endolysosomal pH

(2018) Hari Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation

(2018) Nabab Khan et al.   Journal of Neuroinflammation

HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production

(2018) Rawan El-Amine et al.   Redox Biology

Antiviral effects of ferric ammonium citrate

(2018) Hongbin Wang et al.   Cell Discovery

CNS Persistence of HIV-1 in Children: the Untapped Reservoir

(2018) Ann Chahroudi et al.   Current HIV/AIDS Reports

Regulation of V-ATPase activity

(2017) Michael Forgac   Frontiers in Bioscience-Landmark

Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes

(2017) Carmine Mancone et al.   Proteome Science

Tat is a multifunctional viral protein that modulates cellular gene expression and functions

(2017) Evan Clark et al.   Oncotarget

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function

(2017) Christian Grimm et al.   Frontiers in Pharmacology

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A

(2016) Belén Fernández et al.   Autophagy

Autophagy Captures the Nobel Prize

(2016) Sharon A. Tooze et al.   CELL

MIB: Metal Ion-Binding Site Prediction and Docking Server

(2016) Yu-Feng Lin et al.   Journal of Chemical Information and Modeling

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

Regulation of lysosomal ion homeostasis by channels and transporters

(2016) Jian Xiong et al.   Science China-Life Sciences

The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma

(2016) Yusuke Kamihara et al.   Oncotarget

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

Short Communication: High Cellular Iron Levels Are Associated with Increased HIV Infection and Replication

(2015) Hsiang-Chun Chang et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

The enigma of the clandestine association between chloroquine and HIV-1 infection

(2015) A Chauhan et al.   HIV MEDICINE

The Potential of the CNS as a Reservoir for HIV-1 Infection: Implications for HIV Eradication

(2015) Alessandro F. Fois et al.   Current HIV/AIDS Reports

Macrophage Derived Cystatin B/Cathepsin B in HIV Replication and Neuropathogenesis

(2014) Linda Rivera et al.   CURRENT HIV RESEARCH

Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection

(2014) M. Bae et al.   JOURNAL OF NEUROSCIENCE

HIV-1 target cells in the CNS

(2014) Sarah B. Joseph et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse

(2014) Nazira El-Hage et al.   JOURNAL OF VIROLOGY

Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes

(2014) Ashok Chauhan et al.   VIROLOGY

The Cell Biology of the Endocytic System from an Evolutionary Perspective

(2014) J. G. Wideman et al.   Cold Spring Harbor Perspectives in Biology

The brain and HAART

(2014) Rick B. Meeker et al.   Current Opinion in HIV and AIDS

Is the central nervous system a reservoir of HIV-1?

(2014) Lachlan R. Gray et al.   Current Opinion in HIV and AIDS

Iron Supplementation in HIV-Infected Malawian Children With Anemia: A Double-Blind, Randomized, Controlled Trial

(2013) M. O. Esan et al.   CLINICAL INFECTIOUS DISEASES

Role of cellular iron and oxygen in the regulation of HIV-1 infection

(2013) Sergei Nekhai et al.   Future Virology

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production

(2013) Xuesong Chen et al.   NEUROBIOLOGY OF AGING

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1-Related Central Nervous System Disease: Current Issues in Pathogenesis, Diagnosis, and Treatment

(2013) S. Spudich et al.   Cold Spring Harbor Perspectives in Medicine

Lysosomal Iron, Iron Chelation, and Cell Death

(2012) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Wnt Inhibitor Screen Reveals Iron Dependence of  -Catenin Signaling in Cancers

(2011) S. Song et al.   CANCER RESEARCH

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

(2011) G S Coombs et al.   ONCOGENE

High-Performance Capillary Electrophoresis for Determining HIV-1 Tat Protein in Neurons

(2011) Satish L. Deshmane et al.   PLoS One

Chelation of Lysosomal Iron Protects Dopaminergic SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide Toxicity by Precluding Autophagy and Akt Dephosphorylation

(2011) Roberta Castino et al.   TOXICOLOGICAL SCIENCES

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Host proteins involved in HIV infection: New therapeutic targets

(2009) Nathalie Arhel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Specific iron chelators determine the route of ferritin degradation

(2009) I. De Domenico et al.   BLOOD

Functions of Tat: the versatile protein of human immunodeficiency virus type 1

(2009) B. Romani et al.   JOURNAL OF GENERAL VIROLOGY

HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells

(2008) Patrick T. Ronaldson et al.   JOURNAL OF NEUROCHEMISTRY

Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

(2008) Theophilus S. Vijaykumar et al.   VIROLOGY