Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A

Two-pore channels at the intersection of endolysosomal membrane traffic

(2015) Jonathan S. Marchant et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

(2015) L.-H. You et al.   NEUROSCIENCE

Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease

(2015) Kiersten L. Berggren et al.   Redox Biology

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

(2014) A. Jha et al.   EMBO JOURNAL

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Lysosome-related Organelles as Mediators of Metal Homeostasis

(2014) Crysten E. Blaby-Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition

(2014) L. N. Hockey et al.   JOURNAL OF CELL SCIENCE

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

The role of membrane-trafficking small GTPases in the regulation of autophagy

(2013) C. F. Bento et al.   JOURNAL OF CELL SCIENCE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

(2013) Jianfang Chen et al.   PLoS One

A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition

(2012) Jacob O. Agola et al.   ACS Chemical Biology

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Iron dysregulation in movement disorders

(2012) Petr Dusek et al.   NEUROBIOLOGY OF DISEASE

Genetics and iron in the systems biology of Parkinson’s disease and some related disorders

(2012) Claudia Funke et al.   NEUROCHEMISTRY INTERNATIONAL

Linking NAADP to Ion Channel Activity: A Unifying Hypothesis

(2012) A. H. Guse   Science Signaling

Acidic NAADP-releasable Ca2+ compartments in the megakaryoblastic cell line MEG01

(2011) Natalia Dionisio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TRPML: Transporters of metals in lysosomes essential for cell survival?

(2011) Kirill Kiselyov et al.   CELL CALCIUM

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg

(2011) Timothy F. Walseth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity

(2011) M Lichtenberg et al.   Cell Death & Disease

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

(2010) Michael X. Zhu et al.   FEBS LETTERS

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel

(2010) Jonathan L. Eichelsdoerfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane-domain determinants for SNARE-mediated membrane fusion

(2010) E. Fdez et al.   JOURNAL OF CELL SCIENCE

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells

(2010) Gabriela A. Salvador et al.   NEUROTOXICOLOGY

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

(2009) Eugen Brailoiu et al.   JOURNAL OF CELL BIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Cell-permeant NAADP: A novel chemical tool enabling the study of Ca2+ signalling in intact cells

(2007) Raman Parkesh et al.   CELL CALCIUM