VEGFR2 and hepatocellular carcinoma inhibitory activities of trisubstituted triazole derivatives

Synthesis of antimicrobial azoloazines and molecular docking for inhibiting COVID ‐19

(2021) Zeinab A. Muhammad et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity

(2020) Thoraya A. Farghaly et al.   BIOORGANIC CHEMISTRY

Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor

(2020) Melissa F. Adasme et al.   PLoS One

Synthesis, structure elucidation, DNA binding and molecular docking studies of novel copper(II) complexes of two 1,3,4‐thiadiazolethiosemicarbazone derivatives

(2020) Khadiga M. Takroni et al.   APPLIED ORGANOMETALLIC CHEMISTRY

1,2,4-Triazolin-5-thione derivatives with anticancer activity as CK1γ kinase inhibitors

(2020) Monika Pitucha et al.   BIOORGANIC CHEMISTRY

Discovery of novel indolyl-1,2,4-triazole hybrids as potent vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors with potential anti-renal cancer activity

(2020) Sami A. Al-Hussain et al.   BIOORGANIC CHEMISTRY

Nano-sized formazan analogues: Synthesis, structure elucidation, antimicrobial activity and docking study for COVID-19

(2020) Huda K. Mahmoud et al.   BIOORGANIC CHEMISTRY

A new reactive Ketenaminal: Synthesis, coupling reaction, tautomeric study, docking and antimicrobial evaluation of the products

(2019) Huda K. Mahmoud et al.   Medicinal Chemistry

New Insight into Therapies Targeting Angiogenesis in Hepatocellular Carcinoma

(2019) Mossenta et al.   Cancers

Synthesis and Antimicrobial Evaluation of Novel Pyrazolopyrimidines Incorporated with Mono- and Diphenylsulfonyl Groups

(2019) Alsaedi et al.   MOLECULES

New azoloazine derivatives as antimicrobial agents: Synthesis under microwave irradiations, structure elucidation, and antimicrobial activity

(2019) Asmaa F. Kassem et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Cytotoxicity , docking study of new fluorinated fused pyrimidine scaffold: Thermal and microwave irradiation synthesis

(2019) Alaa M. Abo Alnaja et al.   Medicinal Chemistry

3-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization

(2018) Romeo Romagnoli et al.   BIOORGANIC CHEMISTRY

Anti-Angiogenics: Current Situation and Future Perspectives

(2018) Katja Zirlik et al.   Oncology Research and Treatment

Apatinib targets both tumor and endothelial cells in hepatocellular carcinoma

(2018) Chaoxu Yang et al.   Cancer Medicine

The Role of Angiogenesis in Hepatocellular Carcinoma

(2018) Michael A. Morse et al.   CLINICAL CANCER RESEARCH

Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents

(2017) Ahmed T.A. Boraei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

(2016) Ramandeep Kaur et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives

(2016) Pei-Liang Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antiproliferative evaluation of novel 2-(4 H -1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells

(2016) Necla Kulabaş et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

(2016) Marwa A. Aziz et al.   Scientific Reports

Recent advances bioactive 1,2,4-triazole-3-thiones

(2015) Ş.Güniz Küçükgüzel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 1,2,4-triazoles and triazolo-thiadiazines as anticancer agents

(2015) Thoraya Abd El-Reheem FARGHALY et al.   TURKISH JOURNAL OF CHEMISTRY

Quantitation of VEGFR2 (vascular endothelial growth factor receptor) inhibitors - review of assay methodologies and perspectives

(2014) Kuldeep Sharma et al.   BIOMEDICAL CHROMATOGRAPHY

Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII

(2014) SitaRam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth

(2013) Fuming Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nonclassical antifolates, part 4. 5-(2-Aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study

(2013) Ghada S. Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation

(2012) Pei-Liang Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy

(2010) Eugene L. Piatnitski Chekler et al.   ACS Medicinal Chemistry Letters

VEGF and endothelial guidance in angiogenic sprouting

(2010) Holger Gerhardt   Organogenesis

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

(2009) Kristy J. Gotink et al.   ANGIOGENESIS

Sorafenib

(2009) Gillian M. Keating et al.   DRUGS