Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

Design, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit

(2015) Chunjiang Wu et al.   MOLECULES

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sorafenib-based combination as a first line treatment for advanced hepatocellular carcinoma: A systematic review of the literature

(2014) Omar Abdel-Rahman et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Type II Kinase Inhibitors: An Opportunity in Cancer for Rational Design

(2013) Javier Blanc et al.   Anti-Cancer Agents in Medicinal Chemistry

Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitors

(2012) Mohamed S.A. Elsayed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

(2012) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimetastatic Effect of Sulfamate Carbonic Anhydrase IX Inhibitors in Breast Carcinoma Xenografts

(2012) Roben G. Gieling et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The angiogenic process as a therapeutic target in cancer

(2011) Esther M. Bridges et al.   BIOCHEMICAL PHARMACOLOGY

Impact of aryloxy-linked quinazolines: A novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors

(2011) Antonio Garofalo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antiangiogenic Agents in Combination with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer

(2011) Susanna V. Ulahannan et al.   CANCER INVESTIGATION

Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancer

(2011) Sònia Tugues et al.   MOLECULAR ASPECTS OF MEDICINE

Convenient and Efficient Synthesis of Some Novel Fused Thieno Pyrimidines Using Gewald's Reaction

(2011) Ramakrishna V. S. Nirogi et al.   SYNTHETIC COMMUNICATIONS

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: A structural analysis of the binding interactions of Gleevec®, Nexavar®, and BIRB-796

(2010) Justin Dietrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents

(2010) Wan-Ping Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

(2010) Yuya Oguro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Effective Amidation of Carboxylic Acids Using (4,5-Dichloro-6-oxo-6H-pyridazin-1-yl)phosphoric Acid Diethyl Ester

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Synthesis and Antifungal Activities of New Pyrazole Derivatives via 1,3-dipolar Cycloaddition Reaction

(2010) Chuan-Yu Zhang et al.   Chemical Biology & Drug Design

Phase II study of sunitinib as second-line treatment for advanced gastric cancer

(2010) Yung-Jue Bang et al.   INVESTIGATIONAL NEW DRUGS

VEGF and endothelial guidance in angiogenic sprouting

(2010) Holger Gerhardt   Organogenesis

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

(2009) Kristy J. Gotink et al.   ANGIOGENESIS

Identification, SAR Studies, and X-ray Co-crystallographic Analysis of a Novel Furanopyrimidine Aurora Kinase A Inhibitor

(2009) Mohane Selvaraj Coumar et al.   ChemMedChem

Synthesis and structure of N-alkyl(aryl)aminocarbonyl-1,4-benzoquinone imines

(2009) A. P. Avdeenko et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Cyclooxygenase-1-Selective Inhibitors Are Attractive Candidates for Analgesics That Do Not Cause Gastric Damage. Design and in Vitro/in Vivo Evaluation of a Benzamide-Type Cyclooxygenase-1 Selective Inhibitor

(2008) Hiroki Kakuta et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Bis(2-aminoimidazoline) and Bisguanidine DNA Minor Groove Binders with Potent in Vivo Antitrypanosomal and Antiplasmodial Activity

(2008) Fernando Rodríguez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2

(2008) Qing-Qing Xie et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

The Use of Formamidine Protection for the Derivatization of Aminobenzoic Acids

(2008) Paul E. Zhichkin et al.   JOURNAL OF ORGANIC CHEMISTRY

de novo Design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors

(2008) Masaharu Uno et al.   ORGANIC & BIOMOLECULAR CHEMISTRY