Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease

High Prevalence of Clonal Hematopoiesis‐type Genomic Abnormalities in Cell‐free DNA in Invasive Gliomas After Treatment

(2021) Ryosuke Okamura et al.   INTERNATIONAL JOURNAL OF CANCER

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

(2021) Alexander Heyde et al.   CELL

Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential: Results From the Women's Health Initiative

(2021) Bernhard Haring et al.   Journal of the American Heart Association

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

(2021) Trevor P. Fidler et al.   NATURE

Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

(2020) Chen Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe−/− Mice

(2020) Yang Tang et al.   CARDIOVASCULAR DRUGS AND THERAPY

ASXL1 mutation in clonal hematopoiesis

(2020) Takeshi Fujino et al.   EXPERIMENTAL HEMATOLOGY

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

(2020) Caroline J. Watson et al.   SCIENCE

Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking

(2020) Ahmed A. Z. Dawoud et al.   LEUKEMIA

Chromosomal alterations among age-related haematopoietic clones in Japan

(2020) Chikashi Terao et al.   NATURE

Monogenic and polygenic inheritance become instruments for clonal selection

(2020) Po-Ru Loh et al.   NATURE

Autoimmunity, Clonal Hematopoiesis, and Myeloid Neoplasms

(2020) Delamo I. Bekele et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Clonal haematopoiesis is increased in early onset in systemic sclerosis

(2020) Laure Ricard et al.   RHEUMATOLOGY

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

(2020) Alexander G. Bick et al.   NATURE

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

(2020) Kelly L. Bolton et al.   NATURE GENETICS

Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

(2020) Wesley Tyler Abplanalp et al.   CIRCULATION RESEARCH

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women

(2020) Michael C. Honigberg et al.   CIRCULATION

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice

(2019) Wei Wang et al.   CIRCULATION RESEARCH

Sleep modulates haematopoiesis and protects against atherosclerosis

(2019) Cameron S. McAlpine et al.   NATURE

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis

(2019) Jong Jin Jeong et al.   Cancer Discovery

The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis

(2019) Hideyuki Oguro   Frontiers in Endocrinology

HIV portends a poor prognosis in myelodysplastic syndromes

(2019) Justin D. Kaner et al.   LEUKEMIA & LYMPHOMA

Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation

(2019) Silvia Mas-Peiro et al.   EUROPEAN HEART JOURNAL

Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases

(2019) Pooranee K Morgan et al.   JOURNAL OF LIPID RESEARCH

Genetic IL-6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

(2019) Alexander G. Bick et al.   CIRCULATION

Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients

(2019) Christine R.C. Zhang et al.   EXPERIMENTAL HEMATOLOGY

Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease

(2019) Michael C. Honigberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

(2019) Sisi Chen et al.   Nature Communications

Lineage restriction analyses in CHIP indicate myeloid bias forTET2and multipotent stem cell origin forDNMT3A

(2018) Manuel Buscarlet et al.   BLOOD

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

(2018) Robert L. Bowman et al.   Cell Stem Cell

Somatic Mutations and Clonal Hematopoiesis

(2018) José J. Fuster et al.   CIRCULATION RESEARCH

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Cardiovascular disease in systemic lupus erythematosus

(2018) Yudong Liu et al.   CURRENT OPINION IN RHEUMATOLOGY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

(2018) Mira Jeong et al.   Cell Reports

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

(2018) Po-Ru Loh et al.   NATURE

Clonal hematopoiesis in patients with rheumatoid arthritis

(2018) Paula Savola et al.   Blood Cancer Journal

PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

(2018) Joanne I. Hsu et al.   Cell Stem Cell

Hemothelium, Clonal Hematopoiesis of Indeterminate Potential, and Atherosclerosis

(2018) Abraham Aviv et al.   CIRCULATION

Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms

(2018) Shuhei Asada et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

(2018) Joshua Moss et al.   Nature Communications

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Tet2 restrains inflammatory gene expression in macrophages

(2017) Alyssa H. Cull et al.   EXPERIMENTAL HEMATOLOGY

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

(2017) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

Exome-wide association study of plasma lipids in >300,000 individuals

(2017) Dajiang J Liu et al.   NATURE GENETICS

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases

(2017) et al.   JAMA Oncology

Clonal hematopoiesis in patients with dyskeratosis congenita

(2016) Nieves Perdigones et al.   AMERICAN JOURNAL OF HEMATOLOGY

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

(2016) D. A. Hinds et al.   BLOOD

Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia

(2016) J. Ojha et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

(2016) Matthew W. Snyder et al.   CELL

Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported

(2016) Timothy R. Card et al.   DIGESTIVE DISEASES AND SCIENCES

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

(2015) Qian Zhang et al.   NATURE

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

(2014) R. C. Lindsley et al.   BLOOD

Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

(2014) Wenyu Jiang et al.   INFLAMMATION RESEARCH

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

Inflammatory Bowel Disease Is Associated With an Increased Risk of Melanoma: A Systematic Review and Meta-analysis

(2013) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Disease Activity in Inflammatory Bowel Disease Is Associated with Increased Risk of Myocardial Infarction, Stroke and Cardiovascular Death – A Danish Nationwide Cohort Study

(2013) Søren Lund Kristensen et al.   PLoS One

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

(2011) Andrew J. Murphy et al.   JOURNAL OF CLINICAL INVESTIGATION

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   NEW ENGLAND JOURNAL OF MEDICINE

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE