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Title
Development of Macozinone for TB treatment: An Update
Authors
Keywords
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Journal
Applied Sciences-Basel
Volume 10, Issue 7, Pages 2269
Publisher
MDPI AG
Online
2020-03-27
DOI
10.3390/app10072269
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Note: Only part of the references are listed.- Promiscuous Targets for Antitubercular Drug Discovery: The Paradigm of DprE1 and MmpL3
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- Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
- (2018) Simon Tiberi et al. LANCET INFECTIOUS DISEASES
- An optimized background regimen for treatment of active tuberculosis with the next-generation benzothiazinone Macozinone (PBTZ169)
- (2018) Andréanne Lupien et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization
- (2015) Miroslav Brecik et al. ACS Chemical Biology
- Mode of Action of Clofazimine and Combination Therapy with Benzothiazinones against Mycobacterium tuberculosis
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- New insights into TB physiology suggest untapped therapeutic opportunities
- (2015) Christina E. Baer et al. IMMUNOLOGICAL REVIEWS
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- (2014) Monalisa Chatterji et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Towards a new combination therapy for tuberculosis with next generation benzothiazinones
- (2014) V. Makarov et al. EMBO Molecular Medicine
- Tuberculosis drug discovery in the post-post-genomic era
- (2014) Benoit Lechartier et al. EMBO Molecular Medicine
- Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
- (2012) J. Neres et al. Science Translational Medicine
- Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1
- (2011) Claudia Trefzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis
- (2010) Claudia Trefzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
- (2009) V. Makarov et al. SCIENCE
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