Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells

Cereblon suppresses the lipopolysaccharide-induced inflammatory response by promoting the ubiquitination and degradation of c-Jun

(2018) Jing Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

(2017) Bin Wang et al.   NATURE

The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway

(2016) Weiliang Jiang et al.   CANCER LETTERS

Circadian Clock GeneBmal1Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma

(2016) Qingming Tang et al.   CANCER RESEARCH

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

(2016) Xuan Zhao et al.   CELL

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

The Circadian Clock and Human Health

(2016) Till Roenneberg et al.   CURRENT BIOLOGY

Identification of gene markers in the development of smoking-induced lung cancer

(2016) Zhao Yang et al.   GENE

The intricate dance of post-translational modifications in the rhythm of life

(2016) Arisa Hirano et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The intricate dance of post-translational modifications in the rhythm of life

(2016) Arisa Hirano et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells

(2015) Xiao-ou Hou et al.   ACTA PHARMACOLOGICA SINICA

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation

(2015) Jonathan O. Lipton et al.   CELL

Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

(2015) Jason P. DeBruyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription

(2015) Weiwei Tao et al.   Scientific Reports

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

(2015) Xin Tong et al.   PLoS One

USP2 Regulates the Intracellular Localization of PER1 and Circadian Gene Expression

(2014) Yaoming Yang et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor

(2014) Nicole C. Gossan et al.   NUCLEIC ACIDS RESEARCH

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10

(2013) So Young Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comprehensive Profiling of Protein Ubiquitination for Drug Discovery

(2013) Guoqiang Xu et al.   CURRENT PHARMACEUTICAL DESIGN

A Mental Retardation-linked Nonsense Mutation in Cereblon Is Rescued by Proteasome Inhibition

(2013) Guoqiang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway

(2013) CHAN-HUN JUNG et al.   ONCOLOGY REPORTS

TNF-α modulates expression of the circadian clock genePer2in rheumatoid synovial cells

(2013) K Yoshida et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

p53 regulates Period2 expression and the circadian clock

(2013) Takao Miki et al.   Nature Communications

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

(2012) Francois Gonzalvez et al.   MOLECULAR CELL

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

(2012) Markus Stratmann et al.   MOLECULAR CELL

CircaDB: a database of mammalian circadian gene expression profiles

(2012) Angel Pizarro et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

(2012) Y. Yang et al.   Biology Open

Circadian clock protein BMAL1 regulates cellular senescence in vivo

(2011) Rohini V. Khapre et al.   CELL CYCLE

E3Net: A System for Exploring E3-mediated Regulatory Networks of Cellular Functions

(2011) Youngwoong Han et al.   MOLECULAR & CELLULAR PROTEOMICS

PINA v2.0: mining interactome modules

(2011) Mark J. Cowley et al.   NUCLEIC ACIDS RESEARCH

The De-Ubiquitinylating Enzyme, USP2, Is Associated with the Circadian Clockwork and Regulates Its Sensitivity to Light

(2011) Heather Dehlin Scoma et al.   PLoS One

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Effects of the biological clock gene Bmal1 on tumour growth and anti-cancer drug activity

(2010) Z.-L. Zeng et al.   JOURNAL OF BIOCHEMISTRY

JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

(2010) Michael E. Hughes et al.   JOURNAL OF BIOLOGICAL RHYTHMS

E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb 

(2010) L. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6

(2009) Amanda C. Korchnak et al.   CELLULAR SIGNALLING

Ube3a is required for experience-dependent maturation of the neocortex

(2009) Koji Yashiro et al.   NATURE NEUROSCIENCE

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY